2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. VUF11207

VUF11207 (Compound 29) is a CXCR7 agonist and a high-potency CXCR7 (pKi of 8.1) ligand that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7.

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VUF11207 Chemical Structure

VUF11207 Chemical Structure

CAS No. : 1378524-41-4

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Based on 2 publication(s) in Google Scholar

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Description

VUF11207 (Compound 29) is a CXCR7 agonist and a high-potency CXCR7 (pKi of 8.1) ligand that induces recruitment of β-arrestin2 (pEC50 of 8.8) and subsequent internalization (pEC50 of 7.9) of CXCR7[1].

IC50 & Target[1]

CXCR7

8.1 (pKi)

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
14.1 nM
Compound: 29, VUF11207
Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression after 1 hr by ELISA based internalization assay
Agonist activity at human CXCR7 expressed in HEK293 cells assessed as reduction of receptor surface expression after 1 hr by ELISA based internalization assay
[PMID: 22424612]
HEK-293T EC50
1.6 nM
Compound: 29, VUF11207
Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET assay
Agonist activity at human CXCR7 expressed in HEK293T cells co-expressing beta-arrestin2-YFP assessed as beta-arrestin2 recruitment after 1 hr by BRET assay
[PMID: 22424612]
Molecular Weight

470.58

Formula

C27H35FN2O4
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CN(CCC1)C1CCN(C/C(C)=C/C2=C(C=CC=C2)F)C(C3=CC(OC)=C(C(OC)=C3)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (212.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1250 mL 10.6252 mL 21.2504 mL
5 mM 0.4250 mL 2.1250 mL 4.2501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1250 mL 10.6252 mL 21.2504 mL 53.1259 mL
5 mM 0.4250 mL 2.1250 mL 4.2501 mL 10.6252 mL
10 mM 0.2125 mL 1.0625 mL 2.1250 mL 5.3126 mL
15 mM 0.1417 mL 0.7083 mL 1.4167 mL 3.5417 mL
20 mM 0.1063 mL 0.5313 mL 1.0625 mL 2.6563 mL
25 mM 0.0850 mL 0.4250 mL 0.8500 mL 2.1250 mL
30 mM 0.0708 mL 0.3542 mL 0.7083 mL 1.7709 mL
40 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.3281 mL
50 mM 0.0425 mL 0.2125 mL 0.4250 mL 1.0625 mL
60 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.8854 mL
80 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6641 mL
100 mM 0.0213 mL 0.1063 mL 0.2125 mL 0.5313 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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VUF11207 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VUF112071378524-41-4VUF 11207VUF-11207CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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