2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Val-Ala-PAB

Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis.

For research use only. We do not sell to patients.

Val-Ala-PAB

Val-Ala-PAB Chemical Structure

CAS No. : 1343476-44-7

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Based on 1 publication(s) in Google Scholar

Val-Ala-PAB Related Antibodies

Top Publications Citing Use of Products

View All ADC Linker Isoform Specific Products:

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  • Purity & Documentation

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Description

Val-Ala-PAB is a cleavable ADC linker that can be used for ADCs synthesis[1].

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Val-Ala-PAB Related Antibodies
Molecular Weight

293.37

Formula

C15H23N3O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC(C)[C@H](N)C(N[C@@H](C)C(NC1=CC=C(C=C1)CO)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (397.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4087 mL 17.0435 mL 34.0870 mL
5 mM 0.6817 mL 3.4087 mL 6.8174 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

SDS (393 KB)

COA (244 KB) HNMR (134 KB) RP-HPLC (334 KB) MS (72 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4087 mL 17.0435 mL 34.0870 mL 85.2175 mL
5 mM 0.6817 mL 3.4087 mL 6.8174 mL 17.0435 mL
10 mM 0.3409 mL 1.7043 mL 3.4087 mL 8.5217 mL
15 mM 0.2272 mL 1.1362 mL 2.2725 mL 5.6812 mL
20 mM 0.1704 mL 0.8522 mL 1.7043 mL 4.2609 mL
25 mM 0.1363 mL 0.6817 mL 1.3635 mL 3.4087 mL
30 mM 0.1136 mL 0.5681 mL 1.1362 mL 2.8406 mL
40 mM 0.0852 mL 0.4261 mL 0.8522 mL 2.1304 mL
50 mM 0.0682 mL 0.3409 mL 0.6817 mL 1.7043 mL
60 mM 0.0568 mL 0.2841 mL 0.5681 mL 1.4203 mL
80 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
100 mM 0.0341 mL 0.1704 mL 0.3409 mL 0.8522 mL
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Val-Ala-PAB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Val-Ala-PAB1343476-44-7ADC LinkerAntibody-drug conjugates linkercancertumorADClinkerU87MGInhibitorinhibitorinhibit

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