UNC2383 

UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis^[1][2][3].

UNC2383 (up to 10 μM) enhances SSO effects in HeLa Luc 705 cells^[1].
UNC2383 (10 μM; 2 h) post-treatment combined with anti-MDR1 ASO pre-treatment results in a significant decrease in Pgp expression in NIH-3T3-MDR cells^[1].
UNC2383 (1.25-10 μM; 2 h) induces a large number of small mCherry-GAL9 structures in Huh7 mCherry-GAL9 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC2383 (5 mg/kg; i.p.) increases the level of correctly spliced EGFP mRNA in liver, kidney, lung, intestine and other tissues of EGFP654 transgenic mice, and enhances EGFP protein expression in epithelial cells of bronchi, intestinal crypts and liver cells^[1].
UNC2383 (5 mg/kg; co-administered with 7.5 mg/kg PPMO654; single) enhances the splice-correcting effect of PPMO654 on EGFP mRNA in the lung of EGFP654 transgenic mice, increasing the level of correctly spliced EGFP mRNA, with no significant impairment of liver or kidney function^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

408.88

C₂₂H₂₁ClN₄O₂

2123481-48-9

Solid

White to off-white

O=C(C(O1)=CC2=C1C=CC(Cl)=C2)NC3=NC4=CC=CC=C4N3CCN5CCCC5

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Ling Wang, et al. A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. ACS Chem Biol. 2017 Aug 18;12(8):1999-2007.  [Content Brief]

  [2]. Munson MJ, et al. A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery. Commun Biol. 2021 Feb 16;4(1):211.  [Content Brief]

  [3]. Dang Y, et al. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021 Jun 21;49(11):6100-6113.  [Content Brief]