2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. UNC0006

UNC0006 is a β-arrestin-biased dopamine D2 ligand. UNC0006 can be used in the study of antipsychotic.

For research use only. We do not sell to patients.

UNC0006

UNC0006 Chemical Structure

CAS No. : 1354030-14-0

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Based on 1 publication(s) in Google Scholar

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Description

UNC0006 is a β-arrestin-biased dopamine D2 ligand. UNC0006 can be used in the study of antipsychotic[1].

Cellular Effect
Cell Line Type Value Description References
HEK-293T EC50
> 5 μM
Compound: 1; UNC0006
Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincubated for 30 mins followed by addition of [35S]GTPgammaS measured after 30 mins by [35S]GTPgammaS binding
Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincubated for 30 mins followed by addition of [35S]GTPgammaS measured after 30 mins by [35S]GTPgammaS binding
[PMID: 28489379]
HEK-293T EC50
270 nM
Compound: 1; UNC0006
Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 recruitment after 5 hrs by chemiluminescence assay
Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 recruitment after 5 hrs by chemiluminescence assay
[PMID: 28489379]
Molecular Weight

462.41

Formula

C24H29Cl2N3O2
CAS No.
SMILES

O=C1NC2=CC(OCCCCN3CCN(CCC3)C4=C(Cl)C(Cl)=CC=C4)=CC=C2CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNC0006 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC00061354030-14-0UNC 0006UNC-0006Dopamine Receptordopamine D2antipsychoticβ-arrestinsInhibitorinhibitorinhibit

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