2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. U-99194

U-99194  (Synonyms: U-99194A free base; PNU-99194A; JPC-211)

Cat. No.: HY-12701
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U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors.

For research use only. We do not sell to patients.

U-99194

U-99194 Chemical Structure

CAS No. : 82668-33-5

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Description

U-99194 (PNU-99194) is a selective, potent dopamine D3 receptor antagonist. U-99194 inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].

IC50 & Target[1]

D3 Receptor

 

In Vitro

U-99194 (1 μM, 15 min) prevents the cocaine-induced inhibition of monosynaptic inhibitory postsynaptic currents (IPSCs) evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].
U-99194 (1 μM) blocks the inhibitory effect of PD 128907 ( HY-100539) on the amplitude of monosynaptic IPSCs evoked from stratum radiatum in CA1 pyramidal neurons of rat hippocampal slices[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

U-99194 Related Antibodies
In Vivo

U-99194 (30 mg/kg, i.p., once) significantly suppresses Nicotine (HY-127019)-induced tremor in mice[1].
U-99194 (30 μg/site, intracerebellar microinjection, once) markedly inhibits Nicotine-induced tremor in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in male ddY mice (7-11 weeks of age)[1]
Dosage: 30 mg/kg
Administration: i.p., once
Result: Suppressed Nicotine (HY-127019)-induced tremor.
Animal Model: Nicotine (1 mg/kg, i.p.) was injected to induce kinetic tremor in Male SD rats (7-11 weeks of age)[1]
Dosage: 30 μg/site
Administration: intracerebellar microinjection, once
Result: Suppressed Nicotine (HY-127019)-induced tremor.
Molecular Weight

277.40

Formula

C17H27NO2
CAS No.
SMILES

CCCN(CCC)C1CC2=C(C=C(OC)C(OC)=C2)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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U-99194 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-9919482668-33-5U-99194A PNU-99194A JPC-211U99194U 99194JPC211JPC 211JPC-211Dopamine ReceptorD3 ReceptorAntagonist5-HT1AInhibitorinhibitorinhibit

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