2. Neuronal Signaling Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Monoamine Oxidase Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS)
  4. TT01001

TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM). TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders .

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TT01001

TT01001 Chemical Structure

CAS No. : 1022367-69-6

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TT01001 Related Antibodies

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MAO-A MAO-B

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Description

TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM). TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders [1][2][3].

IC50 & Target[3]

MAO-B

8.84 μM (IC50)

In Vivo

TT01001 (100 mg/kg, p.o., once daily for 28 days) improves type II diabetes without causing weight gain and ameliorates mitochondrial function of db/db mice[1].
TT01001 (1-9 mg/kg, i.p., single dose) attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage (SAH) in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Type II diabetes model established in male, 5-week-old mice of C57BL/6J and BKS.Cg-+ Leprdb/+Leprdb (db/db)[1]
Dosage: 100 mg/kg
Administration: Oral administration (p.o.), once daily for 28 days
Result: Improved diabetes in db/db Mice without causing weight gain.
Was no significant effect on the mtDNA level of the mouse skeletal muscle.
Significantly decreased elevated complex II + III activity and no change in complex I + III or IV activity.
Animal Model: SAH model established in adult male Sprague-Dawley rats weighting 280-320 g[2]
Dosage: Intraperitoneal injection (i.p.), single dose 1 h after SAH
Administration: Oral administration (p.o.), once daily for 28 days
Result: Improved neurological functions at 24 h after subarachnoid hemorrhage.
Reduced the oxidative stress injury at 24 h after subarachnoid hemorrhage.
Reduced neuronal apoptosis at 24 h after subarachnoid hemorrhage.
Molecular Weight

376.30

Formula

C15H19Cl2N3O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)N1CCC(CC1)NC(NC2=CC(Cl)=CC(Cl)=C2)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (332.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6575 mL 13.2873 mL 26.5745 mL
5 mM 0.5315 mL 2.6575 mL 5.3149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6575 mL 13.2873 mL 26.5745 mL 66.4364 mL
5 mM 0.5315 mL 2.6575 mL 5.3149 mL 13.2873 mL
10 mM 0.2657 mL 1.3287 mL 2.6575 mL 6.6436 mL
15 mM 0.1772 mL 0.8858 mL 1.7716 mL 4.4291 mL
20 mM 0.1329 mL 0.6644 mL 1.3287 mL 3.3218 mL
25 mM 0.1063 mL 0.5315 mL 1.0630 mL 2.6575 mL
30 mM 0.0886 mL 0.4429 mL 0.8858 mL 2.2145 mL
40 mM 0.0664 mL 0.3322 mL 0.6644 mL 1.6609 mL
50 mM 0.0531 mL 0.2657 mL 0.5315 mL 1.3287 mL
60 mM 0.0443 mL 0.2215 mL 0.4429 mL 1.1073 mL
80 mM 0.0332 mL 0.1661 mL 0.3322 mL 0.8305 mL
100 mM 0.0266 mL 0.1329 mL 0.2657 mL 0.6644 mL
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TT01001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TT010011022367-69-6TT 01001TT-01001Monoamine OxidaseMitochondrial MetabolismApoptosisReactive Oxygen Species (ROS)MAOEarly brain injuryMitochondrial dysfunctionOxidative stressSubarachnoid hemorrhageIschemicmitoNEETCISD1Inhibitorinhibitorinhibit

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