2. Immunology/Inflammation
  3. TREM receptor
  4. TREM2 agonist-2

TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM).

For research use only. We do not sell to patients.

TREM2 agonist-2 Chemical Structure

TREM2 agonist-2 Chemical Structure

CAS No. : 2738485-98-6

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Based on 1 publication(s) in Google Scholar

TREM2 agonist-2 Related Antibodies

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Description

TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1].

In Vitro

TREM2 agonist-2 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TREM2 agonist-2 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 0-100 μM
Incubation Time: 16 hours
Result: Showed an EC50 value <0.05 μM.
In Vivo

TREM2 agonist-2 (oral gavage; 50 mg/kg; twice daily; one day) finds TREM2 target engagement on microglia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic mice knock-in hTREM2-CV[1]
Dosage: 50 mg/kg
Administration: Oral gavage; 50 mg/kg; twice daily; one day
Result: Increased genes associated with the adaptive immune response, innate immune response, microglia function, cytokine signalling, and cell cycle in hippocampus from animals.
Molecular Weight

451.92

Formula

C24H23ClFN5O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=NC2=C(N=C1C)C=C([C@@H]3C[C@H](C4=CN(N=C4)C)OCC3)N=C2C5=C(C=C(C=C5)Cl)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (221.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2128 mL 11.0639 mL 22.1278 mL
5 mM 0.4426 mL 2.2128 mL 4.4256 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2128 mL 11.0639 mL 22.1278 mL 55.3195 mL
5 mM 0.4426 mL 2.2128 mL 4.4256 mL 11.0639 mL
10 mM 0.2213 mL 1.1064 mL 2.2128 mL 5.5320 mL
15 mM 0.1475 mL 0.7376 mL 1.4752 mL 3.6880 mL
20 mM 0.1106 mL 0.5532 mL 1.1064 mL 2.7660 mL
25 mM 0.0885 mL 0.4426 mL 0.8851 mL 2.2128 mL
30 mM 0.0738 mL 0.3688 mL 0.7376 mL 1.8440 mL
40 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3830 mL
50 mM 0.0443 mL 0.2213 mL 0.4426 mL 1.1064 mL
60 mM 0.0369 mL 0.1844 mL 0.3688 mL 0.9220 mL
80 mM 0.0277 mL 0.1383 mL 0.2766 mL 0.6915 mL
100 mM 0.0221 mL 0.1106 mL 0.2213 mL 0.5532 mL
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TREM2 agonist-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TREM2 agonist-22738485-98-6TREM receptorTriggering receptors expressed on myeloid cellsoral activitytriggering receptor expressed on myeloid cells 2HEK293Inhibitorinhibitorinhibit

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