2. MAPK/ERK Pathway Autophagy Apoptosis
  3. MEK Autophagy Apoptosis
  4. Trametinib-d4

Trametinib-d4 is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis.

For research use only. We do not sell to patients.

Trametinib-d<sub>4</sub> Chemical Structure

Trametinib-d4 Chemical Structure

Size Price Stock Quantity
1 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
5 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
10 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
25 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Get quote  
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Other Forms of Trametinib-d4:

Trametinib-d4 Related Antibodies

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MEK1 MEK2 MEK5 MEK

  • Biological Activity

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Description

Trametinib-d4 is the deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trametinib-d4 Related Antibodies
Molecular Weight

619.42

Formula

C26H19D4FIN5O4
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

CC(NC1=C(C([2H])=C(C(N(C(C(C(N2C3CC3)=O)=C(NC4=CC=C(I)C=C4F)N5C)=C(C)C5=O)C2=O)=C1[2H])[2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6144 mL 8.0721 mL 16.1441 mL
5 mM 0.3229 mL 1.6144 mL 3.2288 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6144 mL 8.0721 mL 16.1441 mL 40.3603 mL
5 mM 0.3229 mL 1.6144 mL 3.2288 mL 8.0721 mL
10 mM 0.1614 mL 0.8072 mL 1.6144 mL 4.0360 mL
15 mM 0.1076 mL 0.5381 mL 1.0763 mL 2.6907 mL
20 mM 0.0807 mL 0.4036 mL 0.8072 mL 2.0180 mL
25 mM 0.0646 mL 0.3229 mL 0.6458 mL 1.6144 mL
30 mM 0.0538 mL 0.2691 mL 0.5381 mL 1.3453 mL
40 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0090 mL
50 mM 0.0323 mL 0.1614 mL 0.3229 mL 0.8072 mL
60 mM 0.0269 mL 0.1345 mL 0.2691 mL 0.6727 mL
80 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5045 mL
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Trametinib-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trametinib-d4MEKAutophagyApoptosisMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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