2. Apoptosis
  3. TNF Receptor
  4. TNF-α-IN-25

TNF-α-IN-25 demonstrates weak to the moderate inhibition of the potassium ion channel encoded by hERG, with a hERG IC50 of 9.2 μM.

For research use only. We do not sell to patients.

TNF-α-IN-25 Chemical Structure

TNF-α-IN-25 Chemical Structure

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TNF-α-IN-25 Related Antibodies

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Description

TNF-α-IN-25 demonstrates weak to the moderate inhibition of the potassium ion channel encoded by hERG, with a hERG IC50 of 9.2 μM[1].

In Vivo

TNF-α-IN-25 (Compound 10) (0.1-30 mg/kg, p.o., twice daily, 17 days) inhibits paw swelling in glucose-6-phosphate isomerase (GPI) arthritis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/J mice were immunized intradermally at the base of the tail with 100 μL of 1:1 (v/v) emulsion containing 300 μg of glucose-6-phosphate isomerase (GPI) and 200 μg of heat inactivated Mycobacterium tuberculosis H37Ra[1]
Dosage: 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: p.o. twice daily for 17 days
Result: Inhibited paw swelling AUC with the 30 mg/kg dose achieving comparable efficacy to anti-TNF antibody treatment.
Inhibited paw swelling AUC dose-dependently.
Molecular Weight

416.45

Formula

C23H21FN6O
SMILES

CC(O)(C1=NC=C(C=N1)C2=CC=C3N=C4CN5CC6=C([C@H](N4C3=N2)C5)C(F)=CC=C6)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNF-α-IN-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-25TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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TNF-α-IN-25
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HY-175250
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