TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride

Name: TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride
Brand: MedChemExpress
SKU: HY-139018A
Rating: 4.5 (1 reviews)

Cat. No.: HY-139018A Purity: 98.28%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugates for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the non-cleavable ADC linker hydroxy-PEG10-acid (HY-133307).

For research use only. We do not sell to patients.

TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride Chemical Structure

CAS No. : 2388520-36-1

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride:

TLR7/8 agonist 4 hydroxy-PEG10-acid Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

873.47

Formula

C₄₁H₆₉ClN₆O₁₂

CAS No.

2388520-36-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCCCC(NC1=C2C(C=CC(N(CC3)CCN3CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=C2)=N4)=NC1=C4N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (114.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1449 mL	5.7243 mL	11.4486 mL
5 mM	0.2290 mL	1.1449 mL	2.2897 mL
10 mM	0.1145 mL	0.5724 mL	1.1449 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.28%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (253 KB) HNMR (282 KB) RP-HPLC (259 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Shelley Erin ACKERMAN, et al. Immunoconjugates targeting her2. WO2020190725A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1449 mL	5.7243 mL	11.4486 mL	28.6215 mL
	5 mM	0.2290 mL	1.1449 mL	2.2897 mL	5.7243 mL
	10 mM	0.1145 mL	0.5724 mL	1.1449 mL	2.8621 mL
	15 mM	0.0763 mL	0.3816 mL	0.7632 mL	1.9081 mL
	20 mM	0.0572 mL	0.2862 mL	0.5724 mL	1.4311 mL
	25 mM	0.0458 mL	0.2290 mL	0.4579 mL	1.1449 mL
	30 mM	0.0382 mL	0.1908 mL	0.3816 mL	0.9540 mL
	40 mM	0.0286 mL	0.1431 mL	0.2862 mL	0.7155 mL
	50 mM	0.0229 mL	0.1145 mL	0.2290 mL	0.5724 mL
	60 mM	0.0191 mL	0.0954 mL	0.1908 mL	0.4770 mL
	80 mM	0.0143 mL	0.0716 mL	0.1431 mL	0.3578 mL
	100 mM	0.0114 mL	0.0572 mL	0.1145 mL	0.2862 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.