2. Protein Tyrosine Kinase/RTK
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  4. Tie2 kinase inhibitor 2

Tie2 kinase inhibitor 2 (compound 7) is a selective Tie2 kinase inhibitor with an IC50 value of 1 μM. Tie2 kinase inhibitor 2 inhibits endothelial cell tube formation, and can be used for Tie2-mediated angiogenic disorders research.

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Tie2 kinase inhibitor 2

Tie2 kinase inhibitor 2 Chemical Structure

CAS No. : 1020412-97-8

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Description

Tie2 kinase inhibitor 2 (compound 7) is a selective Tie2 kinase inhibitor with an IC50 value of 1 μM. Tie2 kinase inhibitor 2 inhibits endothelial cell tube formation, and can be used for Tie2-mediated angiogenic disorders research[1].

IC50 & Target[1]

Tie2

1 μM (IC50)

Tie2

1.3 μM (IC50)

Molecular Weight

529.63

Formula

C31H35N3O5
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(C1=CC(C2=CC=C(CN(CC(N[C@H](C3CCCCC3)C)=O)C(OC4=CC=C(C)C=C4)=O)C=C2)=CN=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8881 mL 9.4406 mL 18.8811 mL
5 mM 0.3776 mL 1.8881 mL 3.7762 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8881 mL 9.4406 mL 18.8811 mL 47.2028 mL
5 mM 0.3776 mL 1.8881 mL 3.7762 mL 9.4406 mL
10 mM 0.1888 mL 0.9441 mL 1.8881 mL 4.7203 mL
15 mM 0.1259 mL 0.6294 mL 1.2587 mL 3.1469 mL
20 mM 0.0944 mL 0.4720 mL 0.9441 mL 2.3601 mL
25 mM 0.0755 mL 0.3776 mL 0.7552 mL 1.8881 mL
30 mM 0.0629 mL 0.3147 mL 0.6294 mL 1.5734 mL
40 mM 0.0472 mL 0.2360 mL 0.4720 mL 1.1801 mL
50 mM 0.0378 mL 0.1888 mL 0.3776 mL 0.9441 mL
60 mM 0.0315 mL 0.1573 mL 0.3147 mL 0.7867 mL
80 mM 0.0236 mL 0.1180 mL 0.2360 mL 0.5900 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4720 mL
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Tie2 kinase inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tie2 kinase inhibitor 21020412-97-8TieAngiopoietin receptorTie2 inhibitorangiogenic disordersInhibitorinhibitorinhibit

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