2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. THR-β agonist 11

THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases.

For research use only. We do not sell to patients.

THR-β agonist 11

THR-β agonist 11 Chemical Structure

CAS No. : 3051970-23-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

THR-β agonist 11 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases[1].

In Vivo

THR-β agonist 11 (Compound 29a) (0.5 mg/kg, p.o., single administration, 24 h) exhibits a superior cholesterol-lower effect in cholesterol-fed Sprague-Dawley rats[1].
THR-β agonist 11 (3 mg/kg, p.o., once daily, 6 weeks) significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels in HFD-CCl4-induced MASH model C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats were fed a normal chow diet supplemented with 1.5% cholesterol and 0.5% cholic acid (w/w) for 2 weeks to establish the model[1]
Dosage: 0.5 mg/kg
Administration: p.o., single administration, 24 h
Result: Achieved a total plasma cholesterol reduction rate of 29.07%.
Animal Model: 4-week-old male C57BL/6J mice were fed a high-fat diet (HFD) for 10 weeks to induce obesity, then intraperitoneally injected with carbon tetrachloride (CCl4) twice a week for 6 weeks to establish the MASH model[1]
Dosage: 3 mg/kg
Administration: p.o., once daily, 6 weeks
Result: Reduced serum total TG, LDL-cholesterol, liver total TC and TG levels.
Decreased serum ALT and AST levels by a notable margin.
Alleviated hepatic steatosis, inflammation and fibrosis.
Downregulated the mRNA expression levels of fibrosis markers Tgfb1 and Acta2.
Molecular Weight

516.95

Formula

C26H30ClN2O5P
CAS No.
SMILES

CC1=CC(OC[P@]2(OCC[C@H](O2)C3=CC=CC(Cl)=C3)=O)=CC(C)=C1CC4=NNC(C(C(C)C)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

THR-β agonist 11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THR-β agonist 113051970-23-8Thyroid Hormone ReceptorTHRTHR-βmetabolic dysfunction-associated steatohepatitischolesterolInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
THR-β agonist 11
Cat. No.:
HY-178015
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.