2. Anti-infection
  3. Bacterial
  4. TH-Z93

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM).

For research use only. We do not sell to patients.

TH-Z93 Chemical Structure

TH-Z93 Chemical Structure

CAS No. : 2260887-09-8

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Based on 1 publication(s) in Google Scholar

TH-Z93 Related Antibodies

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Description

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1].

IC50 & Target

FPPS[1]
In Vivo

TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16-OVA cells (s.c.) xenograft mice model[1].
Dosage: 20 μg
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and prolonged survival.
Molecular Weight

368.26

Formula

C12H22N2O7P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(C(P(O)(O)=O)NC1=NC=CC(OCCCCCC)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7.81 mg/mL (21.21 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7155 mL 13.5774 mL 27.1547 mL
5 mM 0.5431 mL 2.7155 mL 5.4309 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7155 mL 13.5774 mL 27.1547 mL 67.8868 mL
5 mM 0.5431 mL 2.7155 mL 5.4309 mL 13.5774 mL
10 mM 0.2715 mL 1.3577 mL 2.7155 mL 6.7887 mL
15 mM 0.1810 mL 0.9052 mL 1.8103 mL 4.5258 mL
20 mM 0.1358 mL 0.6789 mL 1.3577 mL 3.3943 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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TH-Z93 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH-Z932260887-09-8BacterialBisphosphonateB16-OVAinfluenzaInhibitorinhibitorinhibit

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