2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog Xanthine Oxidase
  4. Tegafur-gimeracil-oteracil potassium

Tegafur-gimeracil-oteracil potassium  (Synonyms: S-1; TS-1)

Cat. No.: HY-16441 Purity: 99.0%
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Tegafur-gimeracil-oteracil potassium (TS-1) is an oral anticancer agent composed of Tegafur (HY-17400), Gimeracil (HY-17469), and Oteracil potassium (HY-17511) at a molar ratio of 1:0.4:1. TS-1 can be utilized in research on the peritoneal dissemination of gastric cancer.

For research use only. We do not sell to patients.

Tegafur-gimeracil-oteracil potassium

Tegafur-gimeracil-oteracil potassium Chemical Structure

CAS No. : 150863-82-4

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Description

Tegafur-gimeracil-oteracil potassium (TS-1) is an oral anticancer agent composed of Tegafur (HY-17400), Gimeracil (HY-17469), and Oteracil potassium (HY-17511) at a molar ratio of 1:0.4:1. TS-1 can be utilized in research on the peritoneal dissemination of gastric cancer[1].

Clinical Trial
Molecular Weight

540.89

Formula

C17H15ClFKN6O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC(NC(N1)=O)=O)O[K].O=C2C=C(C(Cl)=CN2)O.O=C3NC(N(C4OCCC4)C=C3F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 5.56 mg/mL (10.28 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8488 mL 9.2440 mL 18.4880 mL
5 mM 0.3698 mL 1.8488 mL 3.6976 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8488 mL 9.2440 mL 18.4880 mL 46.2201 mL
5 mM 0.3698 mL 1.8488 mL 3.6976 mL 9.2440 mL
10 mM 0.1849 mL 0.9244 mL 1.8488 mL 4.6220 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tegafur-gimeracil-oteracil potassium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tegafur-gimeracil-oteracil150863-82-4S-1 TS-1S1S 1TS1TS 1TS-1Nucleoside Antimetabolite/AnalogXanthine OxidaseXOanticancerTegafurgimeracil oteracilperitoneal disseminationgastric cancerInhibitorinhibitorinhibit

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