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  4. Tallimustine hydrochloride

Tallimustine hydrochloride  (Synonyms: FCE 24517 hydrochloride)

Cat. No.: HY-105270A Purity: 98.23%
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Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent.

For research use only. We do not sell to patients.

Tallimustine hydrochloride Chemical Structure

Tallimustine hydrochloride Chemical Structure

CAS No. : 118438-45-2

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Based on 1 publication(s) in Google Scholar

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Tallimustine hydrochloride Related Antibodies

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Description

Tallimustine hydrochloride, a distamycin-A derivative, is an anticancer agent[1].

Cellular Effect
Cell Line Type Value Description References
L1210 IC50
0.05 μg/mL
Compound: 1 (Tallimustine)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
10.1016/0960-894X(96)00205-3
L1210 IC50
50.3 ng/mL
Compound: 1a
In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells
In vitro test for cytotoxicity after 48 hr of continuous exposure against L1210 murine leukemia cells
10.1016/S0960-894X(97)10120-2
L1210 IC50
50.3 ng/mL
Compound: 4 (Tallimustine)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
In vitro inhibition of L1210 murine leukemia (Drug sensitivity was determined by counting surviving cells after 48 hr of continuous exposure to at least 4 conc. of drug)
10.1016/0960-894X(96)00204-1
Molecular Weight

734.08

Formula

C32H39Cl3N10O4
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(C1=CC=C(N(CCCl)CCCl)C=C1)NC2=CN(C)C(C(NC3=CN(C)C(C(NC4=CN(C)C(C(NCCC(N)=N)=O)=C4)=O)=C3)=O)=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3622 mL 6.8112 mL 13.6225 mL
5 mM 0.2724 mL 1.3622 mL 2.7245 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3622 mL 6.8112 mL 13.6225 mL 34.0562 mL
5 mM 0.2724 mL 1.3622 mL 2.7245 mL 6.8112 mL
10 mM 0.1362 mL 0.6811 mL 1.3622 mL 3.4056 mL
15 mM 0.0908 mL 0.4541 mL 0.9082 mL 2.2704 mL
20 mM 0.0681 mL 0.3406 mL 0.6811 mL 1.7028 mL
25 mM 0.0545 mL 0.2724 mL 0.5449 mL 1.3622 mL
30 mM 0.0454 mL 0.2270 mL 0.4541 mL 1.1352 mL
40 mM 0.0341 mL 0.1703 mL 0.3406 mL 0.8514 mL
50 mM 0.0272 mL 0.1362 mL 0.2724 mL 0.6811 mL
60 mM 0.0227 mL 0.1135 mL 0.2270 mL 0.5676 mL
80 mM 0.0170 mL 0.0851 mL 0.1703 mL 0.4257 mL
100 mM 0.0136 mL 0.0681 mL 0.1362 mL 0.3406 mL
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Tallimustine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tallimustine118438-45-2FCE 24517FCE24517FCE-24517Drug DerivativeDrug derivativedistamycin-A derivative anticancer agentInhibitorinhibitorinhibit

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