2. Reference Standards
  3. Metabolism Standards
  4. Drug Metabolite Standards

Drug Metabolite Standards

A drug metabolite is a byproduct of the body breaking down, or “metabolizing” a drug into a different substance. Most drugs undergo chemical alteration by various bodily systems as a way to create compounds that are more easily excreted from the body. Drug metabolism can produce metabolites with physicochemical and pharmacological properties that differ substantially from those of the parent drug, and consequently have important implications for both drug safety and efficacy.

Drug Metabolite Standards (220):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0384R
    Homovanillic acid (Standard) 306-08-1
    Homovanillic acid (Standard) (Vanilacetic acid (Standard)) is the analytical standard of Homovanillic acid (HY-N0384). This product is intended for research and analytical applications. Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid (Standard)
  • HY-13704R
    SN-38 (Standard) 86639-52-3
    SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).
    SN-38 (Standard)
  • HY-113121R
    Vanillylmandelic acid (Standard) 55-10-7
    Vanillylmandelic acid (Standard) is the analytical standard of Vanillylmandelic acid. This product is intended for research and analytical applications. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.
    Vanillylmandelic acid (Standard)
  • HY-W001080R
    3,4-Dihydroxybenzeneacetic acid (Standard) 102-32-9
    3,4-Dihydroxybenzeneacetic acid (Standard) is the analytical standard of 3,4-Dihydroxybenzeneacetic acid. This product is intended for research and analytical applications. 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid (Standard)
  • HY-138253R
    2′,2′-Difluorodeoxyuridine (Standard) 114248-23-6
    2′,2′-Difluorodeoxyuridine (Standard) is the analytical standard of 2′,2′-Difluorodeoxyuridine. This product is intended for research and analytical applications. 2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells.
    2′,2′-Difluorodeoxyuridine (Standard)
  • HY-107856R
    5-Fluorouridine (Standard) 316-46-1
    5-Fluorouridine (Standard) is the analytical standard of 5-Fluorouridine. This product is intended for research and analytical applications. 5-Fluorouridine, a metabolite of5-Fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.
    5-Fluorouridine (Standard)
  • HY-130189R
    S-Phenylmercapturic acid (Standard) 4775-80-8
    S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid (Standard)
  • HY-B1109R
    N-Acetylprocainamide (Standard) 32795-44-1
    Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride). This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity.
    N-Acetylprocainamide (Standard)
  • HY-N7143R
    Monobutyl phthalate (Standard) 131-70-4
    Monobutyl phthalate (Standard) is the analytical standard of Monobutyl phthalate. This product is intended for research and analytical applications. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant.
    Monobutyl phthalate (Standard)
  • HY-100639R
    Roflumilast N-oxide (Standard) 292135-78-5
    Roflumilast N-oxide (Standard) is the analytical standard of Roflumilast N-oxide. This product is intended for research and analytical applications. Roflumilast N-oxide is a PDE type 4 inhibitor.
    Roflumilast N-oxide (Standard)
  • HY-B1398R
    Ampyrone (Standard) 83-07-8
    Ampyrone (4-Aminophenazone) (Standard) is the analytical standard of Ampyrone (HY-B1398). This product is intended for research and analytical applications. Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy.
    Ampyrone (Standard)
  • HY-17366R
    Clozapine N-oxide (Standard) 34233-69-7
    Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide (Standard)
  • HY-133624R
    1,1,3-Tribromoacetone (Standard) 3475-39-6
    1,1,3-Tribromoacetone (Standard) is the analytical standard of 1,1,3-Tribromoacetone. This product is intended for research and analytical applications. 1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519)[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
    1,1,3-Tribromoacetone (Standard)
  • HY-B1103R
    Hydroxyhexamide (Standard) 3168-01-2
    Hydroxyhexamide (Standard) is an analytical standard for Hydroxyhexamide. This product is intended for research and analytical applications. Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide (Standard)
  • HY-B1348R
    Dimethadione (Standard) 695-53-4
    Dimethadione (Standard) is the analytical standard of Dimethadione. This product is intended for research and analytical applications. Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal[1].
    Dimethadione (Standard)
  • HY-101406R
    Thyroxine sulfate (Standard) 77074-49-8
    Thyroxine sulfate (Standard) is the analytical standard of Thyroxine sulfate. This product is intended for research and analytical applications. Thyroxine sulfate is a thyroid hormone metabolite.
    Thyroxine sulfate (Standard)
  • HY-112226R
    VRT-043198 (Standard) 244133-31-1
    VRT-043198 (Standard) is the analytical standard of VRT-043198. This product is intended for research and analytical applications. VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].
    VRT-043198 (Standard)
  • HY-N3995R
    5β-Dihydrocortisol (Standard) 1482-50-4
    D-Psicose (Standard) is the analytical standard of D-Psicose. This product is intended for research and analytical applications. D-Psicose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    5β-Dihydrocortisol (Standard)
  • HY-W008449R
    1-Methylxanthine (Standard) 6136-37-4
    1-Methylxanthine (Standard) is the analytical standard of 1-Methylxanthine. This product is intended for research and analytical applications. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine (Standard)
  • HY-W019726R
    Dehydro Nifedipine (Standard) 67035-22-7
    Dehydro Nifedipine (Standard) is the analytical standard of Dehydro Nifedipine. This product is intended for research and analytical applications. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine (Standard)