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Results for "

xenobiotic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Cytochrome P450 (19) Drug Intermediate (1) Endogenous Metabolite (6) GLUT (1) Isotope-Labeled Compounds (3) Reference Standards (2)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Inflammation/Immunology (1) Metabolic Disease (18)

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-41494

o-Toluic acid 1 Publications Verification 2-Methylbenzoic acid	Endogenous Metabolite	Others
O-toluic acid (2-Methylbenzoic acid) is an organic compound that is benzoic acid with a methyl group substituted at the 2-position. O-toluic acid can act as an exogenous metabolite and holds some chemical research value .

HY-41494R

o-Toluic acid (Standard) 2-Methylbenzoic acid (Standard)	Reference Standards Endogenous Metabolite	Others
o-Toluic acid (Standard) is the analytical standard of o-Toluic acid. This product is intended for research and analytical applications. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-W674241

4-Ethylphenyl sulfate	Endogenous Metabolite	Cardiovascular Disease
4-Ethylphenyl sulfate is a gut microbial metabolite. 4-Ethylphenyl sulfate is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-W674241A

4-Ethylphenyl sulfate sodium	Endogenous Metabolite	Cardiovascular Disease
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-E70463

Human CYP2E1,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2E1, High-Reductase, a recombinant CYP2E1, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-E70492

Human CYP2C8,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2C8, Low-Reductase, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-E70475

Human CYP2C18,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2C18, Low-Reductase, a recombinant CYP2C18, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-E70471

Human CYP2C8,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2C8, High-Reductase, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-N9348A

Glucoraphenin potassium	Drug Intermediate	Metabolic Disease Cancer
Glucoraphenin potassium induces xenobiotic metabolizing enzymes (XMEs). Glucoraphenin potassium, the predominant and orally active glucosinolate in radish sprouts, is hydrolyzed by myrosinase to sulforaphene that is implicated to exert anticancerogenic effects .

HY-E70484

Human CYP2E1,High-Reductase+b5	Cytochrome P450	Metabolic Disease
Human CYP2E1, High-Reductase+b5, a recombinant CYP2E1, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-E70495

Human CYP2C8,Low-Reductase+b5	Cytochrome P450	Metabolic Disease
Human CYP2C8, ,Low-Reductase+b5, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-E70494

Human CYP2C8,High-Reductase+b5	Cytochrome P450	Metabolic Disease
Human CYP2C8, High-Reductase+b5, a recombinant CYP2C8, is a member of the CYP enzyme family and is involved in the metabolism of xenobiotics in the body .

HY-N9508

Perilla ketone	Cytochrome P450	Inflammation/Immunology
Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema .

HY-E70466

Human CYP1A2,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP1A2, Low-Reductase, a recombinant CYP1A2, is one of the most important cytochrome P450 (CYP) enzymes in the liver. HCYP1A2 is involved in the metabolism of xenobiotics in the human body .

HY-E70457

Human CYP1A2,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP1A2, High-Reductase, a recombinant CYP1A2, is one of the most important cytochrome P450 (CYP) enzymes in the liver. CYP1A2 is involved in the metabolism of xenobiotics in the human body .

HY-41494S1

o-Toluic acid-13C	Isotope-Labeled Compounds Endogenous Metabolite	Others
o-Toluic acid- ¹³C is the ¹³C labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-E70461

Human CYP2D6,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2D6, High-Reductase, a recombinant CYP2D6, is a member of the CYP enzyme family. CYP2D6 plays important roles in the liver and in the brain with regards to xenobiotic metabolism .

HY-E70467

Human CYP2D6,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2D6, Low-Reductase a recombinant CYP2D6, is a member of the CYP enzyme family. CYP2D6 plays important roles in the liver and in the brain with regards to xenobiotic metabolism .

HY-41494S

O-Toluic acid-d7 2-Methylbenzoic acid-d₇	Isotope-Labeled Compounds Endogenous Metabolite	Others
O-Toluic acid-d₇ is the deuterium labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-133078

Thienyldecyl Isothiocyanate	Cytochrome P450	Cancer
Thienyldecyl isothiocyanate is an analog of thienylbutyl isothiocyanate that, like many isothiocyanates, demonstrates antiproliferative activity against cancer cells presumably by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes.

HY-E70468

Human CYP1A1,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP1A1, High-Reductase, a recombinant CYP1A1, is one of the most important cytochrome P450 (CYP) enzymes. Human CYP1A1, High-Reductase is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics .

HY-E70479

Human CYP2C19,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2C19, Low-Reductase, a recombinant CYP2C19, is a member of the CYP enzyme family. CYP2C19 catalyzes metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs .

HY-E70462

Human CYP2C19,High-Reductase	Cytochrome P450	Metabolic Disease
Human CYP2C19, High-Reductase, a recombinant CYP2C19, is a member of the CYP enzyme family. CYP2C19 catalyzes metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs .

HY-E70472

Human CYP1A1,Low-Reductase	Cytochrome P450	Metabolic Disease
Human CYP1A1, High-Reductase, a recombinant CYP1A1, is one of the most important cytochrome P450 (CYP) enzymes. Human CYP1A1, High-Reductase is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics .

HY-E70505

Human CYP2C19,Low-Reductase+b5	Cytochrome P450	Metabolic Disease
Human CYP2C19, Low-Reductase+b5, a recombinant CYP2C19, is a member of the CYP enzyme family. CYP2C19 catalyzes metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs .

HY-E70506

Human CYP2C19,High-Reductase+b5	Cytochrome P450	Metabolic Disease
Human CYP2C19, High-Reductase+b5, a recombinant CYP2C19, is a member of the CYP enzyme family. CYP2C19 catalyzes metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs .

HY-139047

SW157765	GLUT	Cancer
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs .

HY-13690

Mitotane 4 Publications Verification 2,4′-DDD; o,p'-DDD	Apoptosis	Cancer
Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13690S1

Mitotane-13C6 2,4′-DDD-¹³C₆; o,p'-DDD-¹³C₆	Apoptosis	Cancer
Mitotane- ¹³C₆ is the ¹³C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13690S2

Mitotane-d8 2,4′-DDD-d₈; o,p'-DDD-d₈	Apoptosis	Cancer
Mitotane-d₈ is the deuterium labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13690R

Mitotane (Standard) 2,4′-DDD (Standard); o,p'-DDD (Standard)	Reference Standards Apoptosis	Cancer
Mitotane (Standard) is the analytical standard of Mitotane. This product is intended for research and analytical applications. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13690S3

Mitotane-13C12 2,4′-DDD-¹³C₁₂; o,p'-DDD-¹³C₁₂	Isotope-Labeled Compounds Apoptosis	Cancer
Mitotane- ¹³C₁₂ (2,4′-DDD- ¹³C₁₂) is ¹³C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

Cat. No.	Product Name

HY-L076

Drug-Induced Liver Injury (DILI) Compound Library	1,459 compounds
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver. MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1,459 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Drug-Induced Liver Injury (DILI) Compound Library

1,459 compounds

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1,459 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-41494

o-Toluic acid 1 Publications Verification 2-Methylbenzoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
O-toluic acid (2-Methylbenzoic acid) is an organic compound that is benzoic acid with a methyl group substituted at the 2-position. O-toluic acid can act as an exogenous metabolite and holds some chemical research value .

HY-41494R

o-Toluic acid (Standard) 2-Methylbenzoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
o-Toluic acid (Standard) is the analytical standard of o-Toluic acid. This product is intended for research and analytical applications. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .

HY-N9508

Perilla ketone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Labiatae Ulex europaeus L. Source classification Plants Inflammation/Immunology Disease Research Fields	Cytochrome P450
Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema .

Species:	Human (3)
Tag:	His (2) SUMO (1) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72184

	EPHX1 Protein, Human (His-SUMO) EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal xenobiotic; Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal xenobiotic; HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase	Human	E. coli
	The EPHX1 protein is an important biotransformation enzyme that hydrolyzes aromatic hydrocarbons and aliphatic epoxides by catalyzing the transaddition of water. This makes the epoxide less reactive and more water-soluble. EPHX1 Protein, Human (His-SUMO) is the recombinant human-derived EPHX1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P701397

	PXR Protein, Human (His) NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human (His) is the recombinant human-derived PXR protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701396

	PXR Protein, Human NR1I2; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human is the recombinant human-derived PXR protein, expressed by E. coli , with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-41494S

O-Toluic acid-d7
O-Toluic acid-d₇ is the deuterium labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-13690S1

Mitotane-13C6

Mitotane- ¹³C₆ is the ¹³C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-41494S1

o-Toluic acid-13C
o-Toluic acid- ¹³C is the ¹³C labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

HY-13690S2

Mitotane-d8

Mitotane-d₈ is the deuterium labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

HY-13690S3

Mitotane-13C12

Mitotane- ¹³C₁₂ (2,4′-DDD- ¹³C₁₂) is ¹³C labeled Mitotane. Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81245

	CYP1A2 Antibody (YA3505) Cytochrome P450 1A2; cytochrome P450, family 1, subfamily a, polypeptide 2; Cytochrome P450 family 1 polypeptide 2; Cytochrome P450 subfamily I aromatic compound inducible polypeptide 2; Cyp1a2; CYPD45; P-450d; RATCYPD45; CP12; CP 12; P3-450; Aryl hydrocarbon hydroxylase; Dioxin inducable P3 45; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P450 4; P450 form 4; P450 P3; P450(PA); xenobiotic monooxygenase; P450 1A2.	WB, ICC/IF, FC	Human
	CYP1A2 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting CYP1A2, with a predicted molecular weight of 58 kDa. CYP1A2 Antibody can be used for WB,ICC/IF,FC experiments in human backgrounds.