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Results for "

variability

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (1) Endogenous Metabolite (2) Fungal (1) GnRH Receptor (1) P-glycoprotein (1)
By Research Areas:	Cancer (3) Infection (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113327

1,3,7-Trimethyluric acid	Endogenous Metabolite	Cancer
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort .

HY-144863

BAY 1214784	GnRH Receptor	Cancer
BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids .

HY-132189

Laniquidar	P-glycoprotein	Cancer
Laniquidar (R101933) is a noncompetitive, third generation P-glycoprotein (P-gp) inhibitor with an IC₅₀ of 0.51 μM. Laniquidar can be used for modulating multidrug resistance transporters . Laniquidar can also be used for studying acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) . Laniquidar has limited oral bioavailability .

HY-120174

SU200	Endogenous Metabolite	Others
SU200 is a TRPV1 agonist with the activity of regulating intracellular calcium ion concentration. SU200 can induce different calcium ion response modes, showing significant reaction potential and maximum reaction effect. There is obvious response delay and variability in the effects of SU200 in different cells. The use of SU200 may provide pharmacological development opportunities .

HY-W424918

Opromazine hydrochloride	Dopamine Receptor	Neurological Disease
Opromazine hydrochloride is an antipsychotic medication that exhibits sedative and antiemetic pharmacological effects, making it effective for treating psychiatric disorders such as schizophrenia and psychosis. Opromazine hydrochloride functions by reducing dopaminergic activity through the blockade of dopamine receptors in the brain. Opromazine hydrochloride has been analyzed for its metabolites in various microsomal enzymes, revealing differences in formation rates that underscore the variability of drug-metabolizing enzymes in human liver and placenta microsomes.

HY-114881

Frequentin NSC 246118	Fungal	Infection
Frequentin, a secondary metabolite produced by Penicillium janthinellum, is influenced by environmental conditions such as cadmium nitrate and sodium chloride concentrations. In cadmium nitrate-free medium, P. janthinellum produces cyclopenin, carlosic acid, erythroskyrin, kojic acid, and patulin. At 100 ppm cadmium nitrate, it produces cyclopenin, carlosic acid, frequentin, and islandicin. In the presence of sodium chloride, frequentin is produced at 2% and 3% concentrations. These findings indicate that frequentin production is sensitive to specific environmental stressors, highlighting its potential variability under different growth conditions .

Cat. No.	Product Name

HY-L061

Orally Active Compound Library	4,373 compounds
Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration. Thus, oral bioavailability is one of the key considerations in drug design and development. A high oral bioavailability reduces the amount of an administered drug necessary to achieve a desired pharmacological effect and therefore could reduce the risk of side-effects and toxicity. A poor oral bioavailability can result in low efficacy and higher inter-individual variability and therefore can lead to unpredictable response to a drug. Low oral bioavailability in clinical trials is a major reason for drug candidates failing to reach the market. MCE offers a unique collection of 4,373 compounds with confirmed high oral bioavailability. MCE Orally Active Compound Library is a useful tool for discovering new drugs with oral bioavailability.

Orally Active Compound Library

4,373 compounds

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration. Thus, oral bioavailability is one of the key considerations in drug design and development. A high oral bioavailability reduces the amount of an administered drug necessary to achieve a desired pharmacological effect and therefore could reduce the risk of side-effects and toxicity. A poor oral bioavailability can result in low efficacy and higher inter-individual variability and therefore can lead to unpredictable response to a drug. Low oral bioavailability in clinical trials is a major reason for drug candidates failing to reach the market.

MCE offers a unique collection of 4,373 compounds with confirmed high oral bioavailability. MCE Orally Active Compound Library is a useful tool for discovering new drugs with oral bioavailability.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113327

1,3,7-Trimethyluric acid	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort .

HY-114881

Frequentin NSC 246118	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Frequentin, a secondary metabolite produced by Penicillium janthinellum, is influenced by environmental conditions such as cadmium nitrate and sodium chloride concentrations. In cadmium nitrate-free medium, P. janthinellum produces cyclopenin, carlosic acid, erythroskyrin, kojic acid, and patulin. At 100 ppm cadmium nitrate, it produces cyclopenin, carlosic acid, frequentin, and islandicin. In the presence of sodium chloride, frequentin is produced at 2% and 3% concentrations. These findings indicate that frequentin production is sensitive to specific environmental stressors, highlighting its potential variability under different growth conditions .

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