Search Result
Results for "
thiazide
" in MedChemExpress (MCE) Product Catalog:
6
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-Z8643
-
|
|
TGF-β Receptor
Drug Intermediate
|
Others
|
|
HCTZ-CH2-HCTZ is an isomer of HCTZ (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway .
|
-
-
- HY-15833
-
-
-
- HY-15833S
-
-
-
- HY-43670
-
-
-
- HY-43670A
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Chlorthalidone impurity (ammonium) is the ammonium salt form of the metabolite of Chlorthalidone (HY-15833).Chlorthalidone is a thiazide diuretic used in the study of hypertension .
|
-
-
- HY-W011240
-
|
Methforylthiazidine; Rontyl
|
Sodium Channel
Chloride Channel
|
Metabolic Disease
Endocrinology
|
|
Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
|
-
-
- HY-126179
-
|
MG-13054
|
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension .
|
-
-
- HY-P10303
-
|
Cyclo[RGDfK(Azide)]
|
Biochemical Assay Reagents
|
Others
|
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
-
- HY-W663740
-
|
MNP; MeNP; N-Methyl-N'-nitrosopiperazine
|
Biochemical Assay Reagents
|
Others
|
|
1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .
|
-
-
- HY-15833R
-
|
|
NKCC
Reference Standards
|
Cardiovascular Disease
|
|
Chlorthalidone (Standard) is the analytical standard of Chlorthalidone. This product is intended for research and analytical applications. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
|
-
-
- HY-108896
-
|
HOE 140 acetate
|
Bradykinin Receptor
|
Inflammation/Immunology
|
|
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
|
-
-
- HY-B1477
-
-
-
- HY-16403
-
|
|
Others
|
Cardiovascular Disease
|
|
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity .
|
-
-
- HY-126179R
-
|
|
Reference Standards
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Fenquizone (MG-13054) (Standard) is the analytical standard of Fenquizone (HY-126179). This product is intended for research and analytical applications. Fenquizone is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics. Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension.
|
-
-
- HY-B0235
-
|
|
Carbonic Anhydrase
|
Metabolic Disease
|
|
Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
|
-
-
- HY-B0235A
-
|
|
Carbonic Anhydrase
|
Metabolic Disease
|
|
Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
|
-
-
- HY-43670R
-
|
|
Drug Metabolite
Reference Standards
|
Cardiovascular Disease
|
|
Chlorthalidone impurity (Standard) is the analytical standard of Chlorthalidone impurity. This product is intended for research and analytical applications. Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension .
|
-
-
- HY-W011240R
-
|
Methforylthiazidine (Standard); Rontyl (Standard)
|
Sodium Channel
Chloride Channel
Reference Standards
|
Metabolic Disease
Endocrinology
|
|
Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
|
-
-
- HY-B1477R
-
|
|
Reference Standards
Sodium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Clopamide (Standard) is the analytical standard of Clopamide. This product is intended for research and analytical applications. Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research .
|
-
-
- HY-B0235R
-
|
|
Carbonic Anhydrase
Reference Standards
|
Metabolic Disease
|
|
Trichlormethiazide (Standard) is the analytical standard of Trichlormethiazide. This product is intended for research and analytical applications. Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
|
-
-
- HY-B0252
-
|
HCTZ
|
TGF-beta/Smad
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-118472
-
|
CGS 14831
|
Drug Metabolite
Endogenous Metabolite
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
|
-
-
- HY-W700581
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
1-(Methyl-d3)-4-nitrosopiperazine is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .
|
-
-
- HY-B0252S
-
|
HCTZ-d2
|
TGF-beta/Smad
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-B0252R
-
|
HCTZ (Standard)
|
Reference Standards
TGF-beta/Smad
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Hydrochlorothiazide (Standard) is the analytical standard of Hydrochlorothiazide. This product is intended for research and analytical applications. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-B0252S2
-
|
HCTZ-13C6
|
TGF-beta/Smad
Potassium Channel
|
Metabolic Disease
|
|
Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-B0562R
-
|
|
Reference Standards
Carbonic Anhydrase
|
Cardiovascular Disease
Metabolic Disease
|
|
Methyclothiazide (Standard) is the analytical standard of Methyclothiazide. This product is intended for research and analytical applications. Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro .
|
-
-
- HY-B0562
-
|
|
Carbonic Anhydrase
|
Cardiovascular Disease
Metabolic Disease
|
|
Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro .
|
-
-
- HY-B0252S1
-
|
HCTZ-13C,d2
|
Isotope-Labeled Compounds
TGF-beta/Smad
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
Hydrochlorothiazid- 13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-118472R
-
|
CGS 14831 (Standard)
|
Drug Metabolite
Reference Standards
Endogenous Metabolite
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
|
-
-
- HY-B0252S3
-
|
HCTZ-15N2,13C,d2
|
Potassium Channel
TGF-beta/Smad
Isotope-Labeled Compounds
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-N3103R
-
|
Ethyl (E)-p-hydroxycinnamate (Standard); Ethyl trans-4-hydroxycinnamate (Standard)
|
Reference Standards
Drug Metabolite
|
Inflammation/Immunology
|
|
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
|
-
-
- HY-134043
-
|
Chlorthalidone EP Impurity G
|
Carbonic Anhydrase
|
Cardiovascular Disease
|
|
Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.
|
-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10303
-
|
Cyclo[RGDfK(Azide)]
|
Biochemical Assay Reagents
|
Others
|
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
-
- HY-108896
-
|
HOE 140 acetate
|
Bradykinin Receptor
|
Inflammation/Immunology
|
|
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-118472
-
-
-
- HY-118472R
-
-
-
- HY-N3103R
-
|
Ethyl (E)-p-hydroxycinnamate (Standard); Ethyl trans-4-hydroxycinnamate (Standard)
|
Monophenols
other families
Simple Phenylpropanols
Source classification
Phenols
Phenylpropanoids
Plants
|
Reference Standards
Drug Metabolite
|
|
Benazeprilat (Standard) is the analytical standard of Benazeprilat. This product is intended for research and analytical applications. Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-15833S
-
|
|
|
Chlorthalidone-d4 is the deuterium labeled Chlorthalidone. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
|
-
-
- HY-B0252S
-
|
|
|
Hydrochlorothiazid-d2 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-B0252S2
-
|
|
|
Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-W700581
-
|
|
|
1-(Methyl-d3)-4-nitrosopiperazine is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .
|
-
-
- HY-B0252S1
-
|
|
|
Hydrochlorothiazid- 13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
-
- HY-B0252S3
-
|
|
|
Hydrochlorothiazide- 15N2, 13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-P10303
-
|
Cyclo[RGDfK(Azide)]
|
|
Azide
|
|
Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity .
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: