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surrogate

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By Targets:	Biochemical Assay Reagents (4) Drug Metabolite (1) Endogenous Metabolite (1) Orphan Receptor (1) Parasite (1) PKC (1) Reference Standards (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Azide (1)

9

Inhibitors & Agonists

2

Peptides

3

Recombinant Proteins

1

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DLPLTFGGGTK TFA	Biochemical Assay Reagents	Others
DLPLTFGGGTK (TFA) is a surrogate peptide for pembrolizumab identification .

Arachidonic acid-alkyne	Endogenous Metabolite	Metabolic Disease
Arachidonic acid-alkyne is aω‑alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids .

CID 1375606	Orphan Receptor	Neurological Disease Metabolic Disease
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.

(-)-Indolactam V 2 Publications Verification Indolactam V	PKC	Cancer
(-)-Indolactam V is a PKC activator, with K_is of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and K_ds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

Sucrose octaacetate	Biochemical Assay Reagents	Others
Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .

L-Azidonorleucine hydrochloride	Biochemical Assay Reagents	Others
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants . L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Tetranor-PGAM	Drug Metabolite	Endocrinology
Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine .

Antimalarial agent 18	Parasite	Infection
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC₅₀=50 nM) and A. baumanii (IC₅₀=390 nM) .

Sucrose octaacetate (Standard)	Biochemical Assay Reagents Reference Standards	Others
Sucrose octaacetate (Standard) is the analytical standard of Sucrose octaacetate. This product is intended for research and analytical applications. Sucrose octaacetate is an acetylated derivative of sucrose with an intensely bitter tasting and can be used as bitter tasting surrogate. Sucrose octaacetate can be used as food additive and also used as an adhesive and plasticizer. Sucrose octaacetate also used in many pesticides, insecticides, and other toxic products as a deterrent to accidental poisoning. Sucrose octaacetate can also be used as an in situ seed and a soft template to synthesize polyaniline (PANI) nanofibers .

Cat. No.	Product Name	Target	Research Area

DLPLTFGGGTK TFA	Biochemical Assay Reagents	Others
DLPLTFGGGTK (TFA) is a surrogate peptide for pembrolizumab identification .

Proadrenomedullin (45-92), human	Peptides	Cardiovascular Disease
Proadrenomedullin (45-92), human, a mid-regional fragment of proadrenomedullin (MR-proADM), comprises amino acids 45–92 of pre-proADM. Proadrenomedullin (45-92), human has a longer half-life, is relatively stable and is produced in equimolar amounts to adrenomedullin (ADM), making it a surrogate for plasma levels of ADM gene products .

Species:	Human (3)
Tag:	Fc (3)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source

	*Wnt3a Surrogate* Protein, Human (HEK293, Fc)** 3 Publications Verification Wnt3a surrogate, Human (HEK293, Fc)	Human	HEK293
	Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, Fc) is a recombinant Wnt3a protein of human origin, expressed by HEK293 cells with an Fc tag.

	*Wnt3a Surrogate* Protein, Human (HEK293, N-hFc)** Wnt3a surrogate, Human (HEK293, N-hFc)	Human	HEK293
	Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, N-hFc) is the recombinant human-derived Wnt3a Surrogate, expressed by HEK293, with N-hFc labeled tag.

	*Wnt3a Surrogate* Protein, Human (HEK293, C-hFc)** 2 Publications Verification Wnt-3a; Wnt 3a; WNT3A protein; Wnt3a	Human	HEK293
	Wnt3a Surrogate protein is a Wnt recombination protein that plays an important role in embryonic development, adult tissue homeostasis and injury repair. Wnt3a Surrogate protein, consisting of the domain and Fc portion of Wnt3a, helps organoids expand and maintain a source of Wnt. Organoids are a rapidly evolving model system for tissue development, and Wnt3a is considered as the essential protein for organoid growth. Wnt3a or the small molecule glycogen synthase kinase 3 (GSK3) inhibitor CHIR are commonly used as Wnt sources in experiments. However, the application of Wnt3a is hampered by Wnt lipidation, and cross-reactivity with Wnt frizzled (Fzd). Therefore, Wnt3a Surrogate protein was used instead of Wnt3a, as a water-soluble and Fzd-specific alternative Wnt agonist. And the Wnt3a Surrogate protein exhibits tissue selectivity consistent with Fzd isoform specificity. Wnt3a Surrogate Protein, Human (HEK293, C-hFc) is the recombinant human-derived Wnt3a Surrogate, expressed by HEK293, with C-hFc labeled tag.

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Cat. No.	Product Name		Classification

L-Azidonorleucine hydrochloride		Azide
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants . L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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