Search Result

Results for "

substrate peptidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dipeptidyl Peptidase (7) Bacterial (1) Biochemical Assay Reagents (6) ClpP (1) Cytochrome P450 (1) Elastase (1) Fluorescent Dye (3) GLP Receptor (1) P-glycoprotein (2) Ser/Thr Protease (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Targets Recommended: Dipeptidyl Peptidase MARCKS Kallikrein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4464A

Ala-Phe-Pro-pNA TFA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-139440

DL-Leucyl-DL-phenylalanine	Biochemical Assay Reagents	Others
DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .

HY-P4468

Lys-Ala-pNA	Dipeptidyl Peptidase	Others
Lys-Ala-pNA is hydrolytic substrate the of dipeptidyl peptidase (DPP) II with K_m of 0.42 mM .

HY-P4464

Ala-Phe-Pro-pNA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-137199

Pro-Phe-Arg-AMC	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

HY-137870

γ-Glutamyl-β-naphthylamide gamma-Glutamyl-beta-naphthylamide	Biochemical Assay Reagents	Others
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .

HY-P4460

AAA-pNA	Ser/Thr Protease	Cancer
AAA-pNA is a chromogenic substrate of *Tripeptidyl-peptidase* II*. AAA-pNA can be used to test Tripeptidyl-peptidase* II activity .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

HY-114318

Bz-DL-Arg-βNA hydrochloride	Bacterial	Infection
Bz-DL-Arg-βNA hydrochloride is a substrate for endopeptidases but is not hydrolyzed by bacterial dipeptidyl peptidase DPP-III .

HY-P4346

MeOSuc-Ala-Ala-Pro-Met-AMC	Elastase	Others
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dye	Others
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Biochemical Assay Reagents	Others
Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity .

HY-137164A

Ala-Ala-Phe-AMC TFA	Fluorescent Dye	Others
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .

HY-119244

Gly-Pro-pNA hydrochloride	Dipeptidyl Peptidase	Metabolic Disease
Gly-Pro-pNA hydrochloride is a chromogenic substrate that can be cleaved by the circulating enzyme, dipeptidyl peptidase IV (DPP IV). Gly-Pro-pNA can be used to screen for DPP IV inhibitors. Gly-Pro-pNA hydrochloride can be studied as an experimental antidiabetic agents .

HY-W699926

(R)-Naproxen acyl-β-D-glucuronide (R)-Naproxen-β-D-glucuronide	Biochemical Assay Reagents
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.

HY-P1230

HAEGT	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human *dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala* is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .

HY-170569

Cetagliptin	Dipeptidyl Peptidase Cytochrome P450 P-glycoprotein	Metabolic Disease
Cetagliptin is an orally active inhibitor for *dipeptidyl peptidase* 4 (DPP-4) and CYP2D6 (IC₅₀** of 6 µM). Cetagliptin is a substrate for P-glycoprotein. Cetagliptin reduces the GLP-1 degradation, maintains the level of postprandial blood sugar, and can be used in type 2 diabetes mellitus research .

HY-10289

Carmegliptin RO-4876904	Dipeptidyl Peptidase P-glycoprotein	Cardiovascular Disease Metabolic Disease
Carmegliptin (RO-4876904) is an orally active, potent and long-acting *dipeptidyl peptidase* IV** inhibitor. Carmegliptin is also a substrate of P-glycoprotein that synergizes with Verapamil (HY-14275). Carmegliptin improves insulin sensitivity and reduces hepatic glucose production in hyperglycemic mice. Carmegliptin is promising for research of type 2 diabetes, hypertension and cardiovascular disease .

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-175590

DPP-4-IN-17	Dipeptidyl Peptidase	Metabolic Disease
DPP-4-IN-17 is an orally active and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC₅₀ value of 0.12 nM. DPP-4-IN-17 increases the enzyme's K_m value (75.73 μM vs. 27.18 μM of substrate alone) and reduces catalytic efficiency. DPP-4-IN-17 reduces blood glucose levels and reverses weight loss in Streptozotocin (STZ) (HY-13753)/Nicotinamide (NA) (HY-B0150)-induced diabetic rats. DPP-4-IN-17 can be used for the study of type 2 diabetes mellitus (T2DM) .

HY-176001

DPP8/9-IN-1	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC₅₀ values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases .

HY-175597

ClpP modulator-1	ClpP	Infection
ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC₅₀s of 0.35 and 0.58  μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research .

Cat. No.	Product Name	Type

HY-137834

Gly-Pro-AMC hydrobromide 1 Publications Verification	Fluorescent Dyes/Probes
Gly-Pro-AMC hydrobromide is a fluorescent dye, it can be used as a specific fluorescent substrate for detecting Dipeptidyl peptidase IV (DPP-IV) activity .

Cat. No.	Product Name	Type

HY-137870

γ-Glutamyl-β-naphthylamide gamma-Glutamyl-beta-naphthylamide	Cell Assay Reagents
γ-Glutamyl-β-naphthylamide is a substrate for γ-glutamine peptidase. γ-Glutamyl-β-naphthylamide is specifically recognized and the peptide chain is cleaved. γ-Glutamyl-β-naphthylamide can be used to distinguish between gonococci and meningococci .

HY-W699926

(R)-Naproxen acyl-β-D-glucuronide (R)-Naproxen-β-D-glucuronide	Cell Assay Reagents
(R)-Naproxen acyl-β-D-glucuronide ((R)-Naproxen-β-D-glucuronide) is a compound metabolite with anti-inflammatory activity. (R)-Naproxen acyl-β-D-glucuronide can serve as a sensitive fluorescent substrate for proglutamyl peptidase 1, which produces a blue reaction after cleavage.

Cat. No.	Product Name	Target	Research Area

HY-P4464A

Ala-Phe-Pro-pNA TFA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-P4468

Lys-Ala-pNA	Dipeptidyl Peptidase	Others
Lys-Ala-pNA is hydrolytic substrate the of dipeptidyl peptidase (DPP) II with K_m of 0.42 mM .

HY-W010955

Z-Phe-Leu-OH NSC 334018	Biochemical Assay Reagents	Others
Z-Phe-Leu-OH (NSC 334018) is a substrate for carboxypeptidase Y (CPY). Z-Phe-Leu-OH is incubated with recombinant CPY to determine peptidase activity .

HY-P4464

Ala-Phe-Pro-pNA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-137199

Pro-Phe-Arg-AMC	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

HY-P4460

AAA-pNA	Ser/Thr Protease	Cancer
AAA-pNA is a chromogenic substrate of *Tripeptidyl-peptidase* II*. AAA-pNA can be used to test Tripeptidyl-peptidase* II activity .

HY-P4285

β-Aspartylalanine	Peptides	Others
β-Aspartylalanine is a substrate for β-aspartyl peptidase and used to measure β-aspartyl peptidase activity in fecal supernatants .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

HY-P4346

MeOSuc-Ala-Ala-Pro-Met-AMC	Elastase	Others
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .

HY-W436471

H-Ala-Pro-AFC	Peptides	Others
H-Ala-Pro-AFC is a biological active peptide. (This is a fluorescent peptide, Abs/Em=380/500nm. It is a substrate for dipeptidyl peptidase IV (DPP IV) and Xaa-Pro dipeptidase.)

HY-137164A

Ala-Ala-Phe-AMC TFA	Fluorescent Dye	Others
Ala-Ala-Phe-AMC TFA is the TFA salt form for Ala-Ala-Phe-AMC. Ala-Ala-Phe-AMC TFA is a fluorogenic substrate, which is used to for tripeptidyl peptidase II (TPPII) activity determination .

HY-P5323

Dabcyl-AGHDAHASET-Edans	Peptides	Others
Dabcyl-AGHDAHASET-Edans is a biological active peptide. (This is a type I signal peptidase (SPase1) substrate peptide labeled with EDANS/ DABCYL FRET pair, and contains a crucial cleavage site derived from the C-terminal region of the Staphylococcus epidermidis pre-SceD protein. Abs/Em = 340/490 nm.)

HY-P1230

HAEGT	Dipeptidyl Peptidase GLP Receptor	Metabolic Disease
HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide, and the sequence is His-Ala-Glu-Gly-Thr. HAEGT acts as a competitive substrate for probing prime substrate binding sites of human *dipeptidyl peptidase-IV (DPP-IV) 1, in which the N-terminal His-Ala* is catalyzed cleavage by DPP-IV. HAEGT can be used in the research of diabetes, obesity .

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: