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structural analogs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nucleoside Antimetabolite/Analog (4) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Antibiotic (2) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (3) Cannabinoid Receptor (2) Cholinesterase (ChE) (4) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (2) Dopamine Receptor (1) Drug Derivative (1) Drug Isomer (2) Dynamin (1) E1/E2/E3 Enzyme (1) Endogenous Metabolite (6) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (3) FLAP (1) Fungal (1) GPR68 (1) Histone Methyltransferase (1) HIV (2) Interleukin Related (1) Isotope-Labeled Compounds (2) MDM-2/p53 (2) NF-κB (1) OGT (1) Olfactory Receptor (1) Opioid Receptor (1) Parasite (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (3) Proton Pump (1) Pyruvate Kinase (1) Reactive Oxygen Species (4) Reference Standards (1) SGLT (1) SOD (1) STAT (2) TET Protein (1) TNF Receptor (3) VD/VDR (1)
By Research Areas:	Cancer (15) Endocrinology (5) Infection (4) Inflammation/Immunology (6) Metabolic Disease (11) Neurological Disease (15)
Click Chemistry:	Azide (1) Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Nucleoside Antimetabolite/Analog

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15966A

GSK2110183 analog 1 hydrochloride	Akt	Cancer
GSK2110183 analog 1 hydrochloride is the structural analogue of GSK2110183.

HY-16445

Sapacitabine CS682; CYC682	Nucleoside Antimetabolite/Analog	Cancer
Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.

HY-18373

UNC1079	Epigenetic Reader Domain	Cancer
UNC1079 is a piperidine analog of UNC1021, structurally similar but with lower efficacy as an inhibitor.

HY-W005627

Linoleyl alcohol	Drug Derivative	Metabolic Disease
Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .

HY-117223

GEA 857	Potassium Channel	Neurological Disease
GEA 857 is a structural analog of the Serotonin (HY-B1473A) uptake blocker Alaproclate (HY-164011). GEA 857 enhances responses induced by muscarinic receptor agonists by inhibiting certain calcium-dependent potassium channels on membranes, a blockade that can enhance or prolong the muscarinic cholinergic effects. GEA 857 can be used in research on neurodegenerative diseases .

HY-15966

GSK2110183 analog 1	Akt	Cancer
GSK2110183 analog 1 is the structural analogue of GSK2110183.

HY-134031

Ara-ATP	DNA/RNA Synthesis	Others
Ara-ATP, a structural analog of ATP, inhibits poly(A) polymerase activity by competing with ATP .

HY-163330

8-Azakinetin riboside	Nucleoside Antimetabolite/Analog	Cancer
8-Azakinetin riboside is a structural analog of kinetin riboside. Azakinetin riboside shows cytotoxic activity .

HY-N13984

Arylomycin B5	Bacterial	Infection
Arylomycin B5, a microbial metabolite, is a structural analog of Arylomycin B2 (HY-N13981) .

HY-N13982

Arylomycin B3	Bacterial	Infection
Arylomycin B3, a microbial metabolite, is a structural analog of Arylomycin B2 (HY-N13981) .

HY-127162

Prostaglandin K1 PGK1	Prostaglandin Receptor	Others
Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC₅₀ of 2800 nM for EP1 and a K_i of 2800 nM .

HY-12801A

DiZPK hydrochloride 2 Publications Verification	Biochemical Assay Reagents	Others
DiZPK hydrochloride is a structural analog of pyrrolysine (Pyl), acting as a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.

HY-116548

Nitracaine	Dopamine Receptor	Neurological Disease
Nitracaine is a structural analog of Dimethocaine (HY-121870), a local anesthetic that inhibits dopamine reuptake through the dopamine transporter .

HY-N13927

Arisugacin G	Cholinesterase (ChE)	Neurological Disease
Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE .

HY-N13928

Arisugacin H	Cholinesterase (ChE)	Neurological Disease
Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE .

HY-N13925

Arisugacin E	Cholinesterase (ChE)	Neurological Disease
Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE .

HY-N13926

Arisugacin F	Cholinesterase (ChE)	Neurological Disease
Arisugacin F, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin F shows no activity against AChE .

HY-169704

Ogerin analogue 1	GPR68	Neurological Disease
Ogerin analogue 1 (compound 20) is a structural analog of Ogerin (HY-110279). Ogerin analogue 1 is generally used as a negative control .

HY-170476

Δ8-THCB ∆8-Tetrahydrocannabutol	Cannabinoid Receptor	Neurological Disease
Δ8-THCB (∆8-Tetrahydrocannabutol) is a structural analog of phytocannabinoids. Δ8-THCB is also an analog of Δ8-tetrahydrocannabinol .

HY-176007

Fluprostenol methyl amide	Biochemical Assay Reagents	Metabolic Disease
Fluprostenol is a prostaglandin structural analog, and its isopropyl ester derivative (Travoprost, HY-B0584) has demonstrated notable physiological modulatory properties in related studies .

HY-148113

PG 34	OGT	Others
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC₅₀=68 μM), and a close structural analog of OSMI-1 (HY-119738) .

HY-W005627R

Linoleyl alcohol (Standard)	Others	Metabolic Disease
Linoleyl alcohol (Standard) is the analytical standard of Linoleyl alcohol. This product is intended for research and analytical applications. Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .

HY-W012732S

Isoquinoline-d7	Isotope-Labeled Compounds	Cancer
Isoquinoline-d₇ is the deuterium labeled Isoquinoline . Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-170515

RNF5 agonist 1	E1/E2/E3 Enzyme	Inflammation/Immunology
RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells .

HY-145605

Vutiglabridin HSG4112	Reactive Oxygen Species Bacterial PPAR	Metabolic Disease
Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent . Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability .

HY-171468

CC-1069	TNF Receptor	Cancer
CC-1069, a structural analog of thalidomide (HY-14658), is a TNF-α inhibitor that inhibits endothelial. CC-1069 can be used to study angiogenesis-dependent tumors such as gliomas .

HY-W012732R

Isoquinoline (Standard)	TNF Receptor Drug Isomer Interleukin Related HIV NF-κB Parasite	Cancer
Isoquinoline (Standard) is the analytical standard of Isoquinoline. This product is intended for research and analytical applications. Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-122473

fluoro-Dapagliflozin	SGLT	Metabolic Disease
fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with K_i values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents .

HY-131450A

(E)-1α,25-Dihydroxyprevitamin D3	Drug Isomer	Others
(E)-1α,25-Dihydroxyprevitamin D3 is a structurally related analog of 1α,25(OH)2D3 .

HY-124209

9-keto Fluprostenol	Prostaglandin Receptor	Endocrinology
9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. It is anticipated that this analog will have strong affinity for EP receptors and act as a PGE2 agonist.

HY-W001542

5-Hydroxyoxindole	Reactive Oxygen Species	Neurological Disease Metabolic Disease Cancer
5-Hydroxyoxindole is a structural analog of uric acid. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders .

HY-115528

FF-10502	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .

HY-112464

PKR Inhibitor, negative control	Pyruvate Kinase	Neurological Disease
PKR Inhibitor, negative control is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitor, which can be used as a negative control. PKR Inhibitor, negative control can also inhibit LK-induced neuronal death, exhibiting significant neuroprotective effects .

HY-W714509

AH 8507	Opioid Receptor	Neurological Disease
AH 8507 structurally belongs to the opioid compounds and is an analog of AH 7563 (HY-W714505). However, AH 8507 does not exhibit significant analgesic effects in mice in both the phenylquinone test and the hot plate test, with ED₅₀ values greater than 100 mg/kg .

HY-126428

ZL0580	HIV Epigenetic Reader Domain	Infection Inflammation/Immunology
ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter .

HY-W700460

9-β-D-Arabinofuranosyl-2-fluorohypoxanthine	Biochemical Assay Reagents
9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is a nucleoside analog with activity as an inhibitor of certain enzymes. 9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is useful in synthesis and, due to its structural changes, is able to cause base mispairing, thereby stopping chain polymerization reactions.

HY-120395

UC-514321	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .

HY-W653975

Bisphenol B-d8	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
Bisphenol B-d₈ is the deuterium labeled Bisphenol B (HY-W013935). Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC). Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .

HY-151383

DPP-4-IN-1	Dipeptidyl Peptidase	Metabolic Disease
DPP-4-IN-1 (compound d1) is a potent DPP-4 (dipeptidyl peptidase 4) inhibitor, with an IC₅₀of 49 nM. DPP-4-IN-1 is a structurally analogs of Alogliptin (HY-A0023A). DPP-4-IN-1 can be used for diabetes research .

HY-151384

DPP-4-IN-2	Dipeptidyl Peptidase	Metabolic Disease
DPP-4-IN-2 (compound b2) is a potent DPP-4 (dipeptidyl peptidase 4) inhibitor, with an IC₅₀of 79 nM. DPP-4-IN-2 is a structurally analogs of Alogliptin (HY-A0023A). DPP-4-IN-2 can be used for diabetes research .

HY-134070

2-O-Methyl PAF C-16 ET-18-O-OCH3	TNF Receptor	Inflammation/Immunology
2-O-Methyl PAF C-16 (ET-18-O-OCH3), a structural analog of the mediator of inflammation platelet-activating factor (PAF), is a cytotoxic ether lipid. 2-O-Methyl PAF C-16 stimulates TNF-α release in murine macrophages .

HY-W793155

N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine	Nucleoside Antimetabolite/Analog	Others
N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is a nucleoside analog that is structurally related to the natural nucleotide adenosine. N6-Benzoyl-2'-deoxy-3'-O-DMT-adenosine is an activator of ribonucleotide reductase, which converts ribonucleosides to deoxyribonucleosides.

HY-118990

Lobelane hydrochloride	Histone Methyltransferase	Neurological Disease
Lobelane hydrochloride is a biologically active compound that has the activity of inhibiting vesicular monoamine transporter-2 (VMAT2). Lobelane hydrochloride has a low affinity for nicotinic acetylcholine receptors (nAChR), thereby enhancing its selectivity for VMAT2. Synthetic structural changes of lobelane hydrochloride have led to some related analogs that show mild changes in affinity for VMAT2. The most potent synthetic lobelane hydrochloride obtained after structural modification has a K(i) value of 630 nM, showing significant VMAT2 selectivity. The biological activity of lobelane hydrochloride suggests that it has the potential to be used in the development of compounds to inhibit methamphetamine abuse .

HY-170975

UG-650	VD/VDR	Cancer
UG-650 is a non-Gemini analog of UVB1 that combines the structural features of UVB1 and MC 1288. UG-650 can bind to the vitamin D receptor (VDR) and inhibit the proliferation of MCF-7 cells and the migration of MC3T3-E1 cells .

HY-126911

11-keto Fluprostenol Fluprostenol Prostaglandin D2	Prostaglandin Receptor	Endocrinology
11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.

HY-Y1644

(E)-Crotonic acid (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Endogenous Metabolite	Metabolic Disease
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-13863

Hydroxy-Dynasore 5 Publications Verification Dyngo-4a	Dynamin	Neurological Disease
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC₅₀ of 5.7 μM.

HY-N6738

Bafilomycin B1	Antibiotic Bacterial Fungal Proton Pump	Infection Neurological Disease
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets .

Cat. No.	Product Name	Type

HY-W700460

9-β-D-Arabinofuranosyl-2-fluorohypoxanthine	Gene Sequencing and Synthesis
9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is a nucleoside analog with activity as an inhibitor of certain enzymes. 9-β-D-Arabinofuranosyl-2-fluorohypoxanthine is useful in synthesis and, due to its structural changes, is able to cause base mispairing, thereby stopping chain polymerization reactions.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W005627

Linoleyl alcohol	Structural Classification Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Drug Derivative
Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .

HY-W001542

5-Hydroxyoxindole	Structural Classification Neurological Disease Classification of Application Fields Source classification Haldina cordifolia (Roxb.) Ridsd. Metabolic Disease Plants Indole Alkaloids Alkaloids Monophenols Rubiaceae Phenols Disease Research Fields	Reactive Oxygen Species
5-Hydroxyoxindole is a structural analog of uric acid. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders .

HY-N13984

Arylomycin B5	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Arylomycin B5, a microbial metabolite, is a structural analog of Arylomycin B2 (HY-N13981) .

HY-N13982

Arylomycin B3	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Arylomycin B3, a microbial metabolite, is a structural analog of Arylomycin B2 (HY-N13981) .

HY-N13927

Arisugacin G	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Cholinesterase (ChE)
Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE .

HY-N13928

Arisugacin H	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin H, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin H shows no activity against AChE .

HY-N13925

Arisugacin E	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin E, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin E shows no activity against AChE .

HY-N13926

Arisugacin F	Structural Classification Natural Products Microorganisms Source classification	Cholinesterase (ChE)
Arisugacin F, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin F shows no activity against AChE .

HY-W005627R

Linoleyl alcohol (Standard)	Structural Classification Natural Products other families Source classification Plants	Others
Linoleyl alcohol (Standard) is the analytical standard of Linoleyl alcohol. This product is intended for research and analytical applications. Linoleyl alcohol, a structural analog of Linoleic acid with no a-carboxyl group, is a fatty alcohol .

HY-127127

Deamino-NAD	Microorganisms Source classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-Y1644

(E)-Crotonic acid (E)-2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α,β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives .

HY-N6738

Bafilomycin B1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Antibiotic Bacterial Fungal Proton Pump
Bafilomycin B1 is a macrolide antibiotic that can be isolated from mycelium of Streptomyces gresuis. Bafilomycin B1 is neuroprotective against Chloroquine (HY-17589A)-induced death. Bafilomycin B1 is a structural analog of Bafilomycin A1 and has the ability to inhibit V-ATPase. Bafilomycin B1 inhibits significantly the oxidized low density lipoprotein (LDL)-induced accumulation of lipid droplets .

HY-N12109

Albizziin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Others
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification .

HY-W013935

Bisphenol B	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species
Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

HY-W013935R

Bisphenol B (Standard)	Structural Classification Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Endogenous Metabolite Estrogen Receptor/ERR Reactive Oxygen Species
Bisphenol B (Standard) is the analytical standard of Bisphenol B. This product is intended for research and analytical applications. Bisphenol B is a close structural analog of Bisphenol A (BPA) (HY-18260). Bisphenol B is a potent, orally active endocrine disruptor (ED). Bisphenol B binds to G protein-coupled estrogen receptor (GPER) (IC₅₀ = 3.3 μM) with higher affinity and agonistic activity than BPA. Bisphenol B promotes GPER mediated cell migration. Bisphenol B exerts estrogenic effects via GPER pathway at nanomolar concentration. Bisphenol B is used in the manufacture of polycarbonate resin with ED properties .

Cat. No.	Product Name	Chemical Structure

HY-W012732S

Isoquinoline-d7
Isoquinoline-d₇ is the deuterium labeled Isoquinoline . Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities .

HY-W653975

Bisphenol B-d8
Bisphenol B-d₈ is the deuterium labeled Bisphenol B (HY-W013935). Bisphenol B is a very close structural analog of Bisphenol A (HY-18260), an endocrine disrupting chemical (EDC). Bisphenol B shows endocrine disruptive properties or other adverse effects on animal models .

Cat. No.	Product Name		Classification

HY-W001538

S-Propargylcysteine SPRC		Alkynes
S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H₂S-releasing compound. S-Propargylcysteine reduces Ca ²⁺ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties .

HY-118197

L-669083		Azide
L-669083 is a leukotriene biosynthesis inhibitor whose structure is based on a mixture of indole and quinoline. In this study, a potent radioiodinated photoaffinity analog of L-689,037, [125I] L-691,678, was developed and characterized for immunoprecipitation studies showing that the quindole series of leukotriene biosynthesis inhibitors directly interact with FLAP. In addition, the results showed that MK-886, L-674,573, and L-689,037 competed with [125I] L-691,678 and [125I] L-669083 for binding to FLAP in a concentration-dependent manner, indicating that these three leukotriene biosynthesis inhibitors share a binding site on FLAP, further demonstrating that FLAP is a suitable target for structurally diverse leukotriene biosynthesis inhibitors.

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structural analogs

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