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Results for "

sickled hemoglobin

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106509
    Velaresol

    BW 12C; 12C79; BW 12C79

    		 Others Others
    Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro . Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.
    Velaresol
  • HY-167874
    ASP-8731

    		Heme Oxygenase (HO) Inflammation/Immunology
    ASP8731 is a selective inhibitor of BACH1. ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease .
    ASP-8731
  • HY-160610A
    Carbamoyl phosphate dilithium salt

    		Others Others
    Carbamoyl phosphate dilithium salt is an antisickling agent and plays a significant role in the urea cycle. Carbamoyl phosphate dilithium salt carbamylates the amino-terminal valine residues of hemoglobin S in erythrocytes, which interferes with the sickling phenomenon. Carbamoyl phosphate dilithium salt exhibits toxicity due to the lithium cation .
    Carbamoyl phosphate dilithium salt
  • HY-139293
    PF-07059013

    		Others Cardiovascular Disease
    PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research .
    PF-07059013
  • HY-106509R
    Velaresol (Standard)

    BW 12C (Standard); 12C79 (Standard); BW 12C79 (Standard)

    		 Reference Standards Others Others
    Velaresol (Standard) is the analytical standard of Velaresol. This product is intended for research and analytical applications. Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro . Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.
    Velaresol (Standard)
  • HY-W175543
    Methoxyurea

    		Hemoglobin Cardiovascular Disease
    Methoxyurea (Compound 3) is a potential regulator of nitric oxide (NO) donors that acts on hemoglobins such as oxy-hemoglobin (OxyHb) and met-hemoglobin (MetHb). Methoxyurea is promising for research of sickle cell disease (SCD) .
    Methoxyurea
  • HY-165517
    Methyl acetimidate

    		Others Cardiovascular Disease
    Methyl acetimidate is an imidoester that can inhibit the formation of sickle cells. Methyl acetimidate enhances the oxygen affinity and gelling properties of high molecular weight hemoglobin (HMW Hb) by modifying the amino groups of hemoglobin, thereby suppressing the formation of sickle cells. Methyl acetimidate can be used in research related to anemia .
    Methyl acetimidate
  • HY-141876
    PRT543

    		Histone Methyltransferase Cancer
    PRT543 is a PRMT5 inhibitor to research cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
    PRT543
  • HY-163819
    WIZ degrader 3

    		Histone Acetyltransferase Cardiovascular Disease
    WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .
    WIZ degrader 3
  • HY-159098
    dWIZ-1

    		Molecular Glues Histone Acetyltransferase Others
    dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) .
    dWIZ-1
  • HY-110130
    RN-1 dihydrochloride

    		Histone Demethylase Cardiovascular Disease Cancer
    RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively .
    RN-1 dihydrochloride
  • HY-113427AR
    cis-Vaccenic acid (Standard)

    		Antibiotic Reference Standards Cancer
    cis-Vaccenic acid (Standard) is the analytical standard of cis-Vaccenic acid. This product is intended for research and analytical applications. cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .
    cis-Vaccenic acid (Standard)
  • HY-113427A
    cis-Vaccenic acid

    		Antibiotic Cancer
    cis-Vaccenic acid, the antiviral extract from Rhodopseudomonas capsulate and the predominant active component of Rhodopseudomonas capsulate , acts a potential fetal hemoglobin inducer .
    cis-Vaccenic acid

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