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serotonergic neurotransmission

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12390
    Lofepramine

    Lopramine

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine
  • HY-106361A
    Flerobuterol hydrochloride

    CRL 40827 hydrochloride

    		 Adrenergic Receptor Neurological Disease
    Flerobuterol hydrochloride is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol hydrochloride enhances serotonergic neurotransmission .
    Flerobuterol hydrochloride
  • HY-106361
    Flerobuterol

    CRL 40827

    		 Adrenergic Receptor Neurological Disease
    Flerobuterol is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol enhances serotonergic neurotransmission .
    Flerobuterol
  • HY-A0160
    Indalpine

    LM 5008

    		 Serotonin Transporter Neurological Disease
    Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM . Indalpine, two antidepressant agent .
    Indalpine
  • HY-W707158
    Norfenfluramine hydrochloride

    (±)-Norfenfluramine hydrochloride

    		 Drug Metabolite Neurological Disease
    Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is the primary metabolite of Fenfluramine, formed through N-dealkylation of Fenfluramine. Norfenfluramine hydrochloride is also a potent anorexiant. Norfenfluramine hydrochloride can regulate serotonergic neurotransmission. In addition, Norfenfluramine hydrochloride exhibits sedative effects after acute administration .
    Norfenfluramine hydrochloride
  • HY-12390A
    Lofepramine hydrochloride

    Lopramine hydrochloride

    		 5-HT Receptor Adrenergic Receptor Neurological Disease
    Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .
    Lofepramine hydrochloride

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