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schisandra chinensis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (2) Apoptosis (3) Autophagy (7) Bcl-2 Family (1) CaMK (1) Caspase (1) CDK (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) ERK (1) Ferroptosis (1) Glutathione S-transferase (1) GSK-3 (1) HBV (1) HCV (1) HIV (3) HSP (1) Interleukin Related (2) JNK (1) Keap1-Nrf2 (2) Microtubule/Tubulin (1) mTOR (1) NF-κB (2) NO Synthase (3) P-glycoprotein (1) p38 MAPK (1) PARP (2) PERK (1) PI3K (1) Reactive Oxygen Species (ROS) (6) Reference Standards (3) Reverse Transcriptase (1) TNF Receptor (1) Tyrosinase (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (1) Infection (4) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Akt (1)

AMPK (2)

Apoptosis (3)

Autophagy (7)

Bcl-2 Family (1)

CaMK (1)

Caspase (1)

CDK (1)

Cyclin G-associated Kinase (GAK) (1)

Cytochrome P450 (2)

ERK (1)

Ferroptosis (1)

Glutathione S-transferase (1)

GSK-3 (1)

HBV (1)

HCV (1)

HIV (3)

HSP (1)

Interleukin Related (2)

JNK (1)

Keap1-Nrf2 (2)

Microtubule/Tubulin (1)

mTOR (1)

NF-κB (2)

NO Synthase (3)

P-glycoprotein (1)

p38 MAPK (1)

PARP (2)

PERK (1)

PI3K (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (3)

Reverse Transcriptase (1)

TNF Receptor (1)

Tyrosinase (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (8)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0691

Schisandrin 3 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Autophagy	Inflammation/Immunology Cancer
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N12046

Schineolignin B	HIV	Infection Inflammation/Immunology Cancer
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N11944

Schiarisanrin E	Others	Others
Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .

HY-N0859A

Schisanhenol B	PI3K Tyrosinase	Cardiovascular Disease
Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure .

HY-N0691R

Schisandrin (Standard) Schizandrin (Standard); Schizandrol (Standard); Schizandrol-A (Standard)	Reference Standards Autophagy	Inflammation/Immunology Cancer
Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N12047

Schineolignin C	HIV	Infection Inflammation/Immunology Cancer
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N12714

Interiorin C	Others	Others
Interiorin C is the key active ingredient and key bioactivity marker in Schisandra chinensis (K. Interiorin) that is directly related to the improvement of hematopoietic function. Modern pharmacological research attributes Schisandra chinensis's blood-tonifying effects to its antioxidant and immunomodulatory activities .

HY-N11947

Schisanlignone B	Others	Others
Schisanligone B is a lignan isolated from Schisandra chinensis seeds .

HY-N8622A

Heteroclitin B	Others	Others
Heteroclitin B is a saturated dibenzocyclooctene lignan isolated from the stems of Schisandra chinensis.

HY-N11971

Yunnankadsurin B	Others	Others
Yunnankadsurin B is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

HY-N11917

Schisantherin S	Others	Others
Schisantherin S is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

HY-N3481

Isogomisin O	Others	Others
Isogomisin O is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .

HY-N7958

Gomisin F	Others	Others
Gomisin F is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .

HY-N0089

Schisandrin B Maximum Cited Publications 9 Publications Verification γ-Schisandrin; Wuweizisu B	Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

HY-N2267

(+)-Schisandrin B	Reactive Oxygen Species (ROS)	Inflammation/Immunology
(+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .

HY-122935

Nigranoic acid	HIV Reverse Transcriptase	Infection
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N0089R

Schisandrin B (Standard) γ-Schisandrin (Standard); Wuweizisu B (Standard)	Reference Standards Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Schisandrin B (Standard) is the analytical standard of Schisandrin B. This product is intended for research and analytical applications. Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

HY-N0859B

Schisanchinin D	NO Synthase	Neurological Disease
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD) .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy	Cancer
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N0692R

Schisandrol B (Standard) Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy	Cancer
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-118129

Schisandronic acid Ganwuweizic acid	PARP Apoptosis	Cancer
Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects .

HY-N0385

Gomisin J 3 Publications Verification	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

HY-N6866

Gomisin N	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

HY-B0766

Bicyclol SY801	Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species (ROS) Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis	Infection Inflammation/Immunology Cancer
Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .

Schisandrin 3 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Autophagy
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

Schineolignin B	Structural Classification Monophenols Source classification Phenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

Schiarisanrin E	Structural Classification Schizandra arisanensis Source classification Lignans Phenylpropanoids Plants Schisandraceae	Others
Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .

Schisanhenol B	Structural Classification Source classification Lignans Phenols Phenylpropanoids Kadsura coccinea (Lem.) A. C. Smith Plants Schisandraceae	PI3K Tyrosinase
Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure .

Schisandrin (Standard) Schizandrin (Standard); Schizandrol (Standard); Schizandrol-A (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reference Standards Autophagy
Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

Schineolignin C	Structural Classification Source classification Phenols Polyphenols Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	HIV
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

Interiorin C	Structural Classification Source classification Lignans Celastraceae Celastrus Phenylpropanoids Plants Celastrus orbiculatus Thunb.	Others
Interiorin C is the key active ingredient and key bioactivity marker in Schisandra chinensis (K. Interiorin) that is directly related to the improvement of hematopoietic function. Modern pharmacological research attributes Schisandra chinensis's blood-tonifying effects to its antioxidant and immunomodulatory activities .

Schisanlignone B	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Schisanligone B is a lignan isolated from Schisandra chinensis seeds .

Heteroclitin B	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandra rubriflora (Franch) . Rehd. et Wils. Schisandraceae	Others
Heteroclitin B is a saturated dibenzocyclooctene lignan isolated from the stems of Schisandra chinensis.

Yunnankadsurin B	Structural Classification Kadsura heteroclita (Roxb.) Craib Source classification Lignans Phenylpropanoids Plants Schisandraceae	Others
Yunnankadsurin B is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

Schisantherin S	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Schisantherin S is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

Isogomisin O	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Others
Isogomisin O is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .

Gomisin F	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Others
Gomisin F is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .

Schisandrin B Maximum Cited Publications 9 Publications Verification γ-Schisandrin; Wuweizisu B	Structural Classification Neurological Disease Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Autophagy Reactive Oxygen Species (ROS)
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

(+)-Schisandrin B	Structural Classification Natural Products Classification of Application Fields Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species (ROS)
(+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .

Nigranoic acid	Infection Triterpenes Classification of Application Fields Terpenoids Source classification Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.	HIV Reverse Transcriptase
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

Schisandrin B (Standard) γ-Schisandrin (Standard); Wuweizisu B (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reference Standards Autophagy Reactive Oxygen Species (ROS)
Schisandrin B (Standard) is the analytical standard of Schisandrin B. This product is intended for research and analytical applications. Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

Schisanchinin D	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	NO Synthase
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD) .

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

Schisandrol B (Standard) Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

Gomisin J 3 Publications Verification	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

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