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Results for "

rhythm

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Apoptosis (1) Calcium Channel (1) Casein Kinase (7) Cholinesterase (ChE) (1) Cryptochrome (3) Cytochrome P450 (7) Deubiquitinase (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) GABA Receptor (2) Isotope-Labeled Compounds (5) Melatonin Receptor (3) Neuropeptide Y Receptor (1) Orexin Receptor (OX Receptor) (1) P2X Receptor (2) p38 MAPK (3) Parasite (1) Potassium Channel (1) Ras (1) REV-ERB (1) SOD (1) Sodium Channel (2) Trace Amine-associated Receptor (TAAR) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (7) Neurological Disease (14)

By Targets:

5-HT Receptor (1)

Acyltransferase (1)

Apoptosis (1)

Calcium Channel (1)

Casein Kinase (7)

Cholinesterase (ChE) (1)

Cryptochrome (3)

Cytochrome P450 (7)

Deubiquitinase (1)

E3 Ligase Ligand-Linker Conjugates (1)

Endogenous Metabolite (1)

GABA Receptor (2)

Isotope-Labeled Compounds (5)

Melatonin Receptor (3)

Neuropeptide Y Receptor (1)

Orexin Receptor (OX Receptor) (1)

P2X Receptor (2)

p38 MAPK (3)

Parasite (1)

Potassium Channel (1)

Ras (1)

REV-ERB (1)

SOD (1)

Sodium Channel (2)

Trace Amine-associated Receptor (TAAR) (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (6)

Endocrinology (1)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (7)

Neurological Disease (14)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148765

CLK8	Cryptochrome	Metabolic Disease Cancer
CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms .

HY-76632

4-Hydroxyisophthalic acid	Cholinesterase (ChE) SOD	Neurological Disease
4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies .

HY-14415

SR8278 Maximum Cited Publications 11 Publications Verification	REV-ERB	Neurological Disease Metabolic Disease
SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC₅₀ of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .

HY-148766

VU661	Others	Metabolic Disease
VU661, a phenazine carboxamide, is a modulator of circadian rhythms to produce a period lengthening of the circadian rhythm. VU661 is a redox-active small molecule .

HY-120672

LG 83-6-05	Sodium Channel	Cardiovascular Disease
LG 83-6-05 is an inhibitor for sodium channel. LG 83-6-05 can be used in the research about cardiac rhythm disorders .

HY-B1751S

Quinidine-d3	Parasite	Infection Cardiovascular Disease
Quinidine-d₃ is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

HY-171300

p38α inhibitor 8	p38 MAPK Casein Kinase	Inflammation/Immunology
p38α inhibitor 8 (Compound 1) exhibits inhibitory activity against p38α MAPK and CK1δ with IC₅₀ of 0.21 µM and 0.202 µM ^[1]>.

HY-171301

p38α MAPK/CK1δ inhibitor-1	p38 MAPK Casein Kinase	Inflammation/Immunology
p38α MAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38α MAPK and CK1δ with IC₅₀s of 0.185 µM and 0.089 µM .

HY-116046

GR 196429	Melatonin Receptor	Others
GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR 196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice .

HY-171292

CK1δ-IN-9	Casein Kinase p38 MAPK	Others
CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC₅₀ of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC₅₀ of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance .

HY-134194

KL201 1 Publications Verification	Cryptochrome	Metabolic Disease
KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues .

HY-145967

FT709 1 Publications Verification	Deubiquitinase	Cancer
FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

HY-128677

NCC007	Casein Kinase	Neurological Disease
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC₅₀s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms .

HY-131947

DH97-7	Melatonin Receptor	Neurological Disease
DH97 is a potent melatonin receptor 2 (MT2) antagonist with K_i values of 252 nM and 1100 nM for MT2 and MT1, respectively .

HY-149101

Riboxin IDP	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation .

HY-B1812

Veratrole 1,2-Dimethoxybenzene	Cytochrome P450	Others
Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-171278

Casein kinase 1δ-IN-28	Casein Kinase	Metabolic Disease Cancer
Casein kinase 1δ-IN-28 (Compound 4) is the inhibitor for CK1ε with an IC₅₀ of 0.0146 μM. Casein kinase 1δ-IN-28 exhibits a metabolite rate in human liver microsomes of 52% .

HY-B1812S3

Veratrole-d6 1,2-Dimethoxybenzene-d₆	Isotope-Labeled Compounds Cytochrome P450	Others
Veratrole-d₆ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S

Veratrole-d4 1,2-Dimethoxybenzene-d₄	Isotope-Labeled Compounds Cytochrome P450	Others
Veratrole-d₄ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S1

Veratrole-d2 1,2-Dimethoxybenzene-d₂	Isotope-Labeled Compounds Cytochrome P450	Others
Veratrole-d₂ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S2

Veratrole-d10 1,2-Dimethoxybenzene-d₁₀	Isotope-Labeled Compounds Cytochrome P450	Others
Veratrole-d₁₀ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-170862

E3 Ligase Ligand-linker Conjugate 163	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 163 is the E3 ligase ligand (E3 ligase Ligand 58, HY-170861)-linker conjugate part of AH078 (HY-170859). AH078 is a PROTAC that targets the degradation of CK1δ and CK1ε, and can be used for research related to circadian rhythm disorders .

HY-108468

KL001	Cryptochrome	Metabolic Disease
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .

HY-15469

GW791343 dihydrochloride	P2X Receptor	Neurological Disease
GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC₅₀ of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease .

HY-15470

GW791343 trihydrochloride	P2X Receptor	Neurological Disease
GW791343 trihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC₅₀ of 6.9-7.2. GW791343 trihydrochloride can enhance ATP rhythm. GW791343 trihydrochloride can be used in study of neurological disease .

HY-B1812R

Veratrole (Standard) 1,2-Dimethoxybenzene (Standard)	Cytochrome P450	Others
Veratrole (Standard) is the analytical standard of Veratrole. This product is intended for research and analytical applications. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S4

Veratrole-d2-1 1,2-Dimethoxybenzene-d₂-1	Isotope-Labeled Compounds Cytochrome P450	Others
Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-115839

Detajmium Tachmalcor free base	Sodium Channel	Others
Detajmium (Tachmalcor free base) is a Na?-channel blocker with activity to inhibit ventricular conduction and refractoriness. Detajmium (0.3μM) prolongs intraventricular conduction time comparable to propafenone (0.3μM) during sinus rhythm, but the time constant for reaching steady state during rapid ventricular pacing is significantly longer for Detajmium, indicating a unique temporal profile for its heart rate-dependent effects.

HY-115519

(E/Z)-GO289 2 Publications Verification	Casein Kinase	Cancer
(E/Z)-GO289 is a potent and selective casein kinase 2 (CK2) inhibitor (IC₅₀=7 nM). (E/Z)-GO289 strongly lengthens circadian period. (E/Z)-GO289 exhibits cell type–dependent inhibition of cancer cell growth that correlated with cellular clock function .

HY-104064

1A-116 5+ Cited Publications	Ras Apoptosis	Cancer
1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo .

HY-108015

RO5263397	Trace Amine-associated Receptor (TAAR)	Neurological Disease
RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC₅₀s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect .

HY-100813R

Saclofen (Standard)	GABA Receptor	Neurological Disease Inflammation/Immunology
Saclofen (Standard) is the analytical standard of Saclofen.

HY-100813

Saclofen 3 Publications Verification	GABA Receptor	Neurological Disease Inflammation/Immunology
Saclofen is an orally active and a competitive GABA_B receptor antagonist with an IC₅₀ of 7.8 μM. Saclofen has weak antagonistic effects on GABA_B1b and GABA_B2 heterodimeric recombinant receptors. Saclofen inhibits the binding of Baclofen (HY-B0007) to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts, and exhibits anti-inflammatory and analgesic effects in rats .

HY-157521

AANAT-IN-1	Acyltransferase	Endocrinology
AANAT-IN-1 (compound 30) is a potent inhibitor (IC₅₀: 10μM) of aralkylamine N-acetyltransferase (AANAT). AANAT is responsible for the synthesis of melatonin, which is involved in disorders such as seasonal affective disorder (SAD) in which melatonin levels are abnormally high .

HY-106136

TIK-301 PD-6735; LY-156735	Melatonin Receptor 5-HT Receptor	Neurological Disease
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT₁ and MT₂ receptors agonist with K_is of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT_2B/5-HT_2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment .

HY-162712

OX-201	Orexin Receptor (OX Receptor)	Neurological Disease
OX-201 is a selective agonist for OX2R with an EC₅₀ of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a manner dependent on neuronal activity and are cleared from the brain via lymphatic pathways. The outflow of pathological proteins to the ISF is related to the arousal state of neurons. OX-201 can induce neuronal awakening and promote the release of tau into the hippocampal ISF. Although OX-201 does not alter hippocampal tau levels, it has potential applications for Alzheimer's disease (AD) associated with sleep/wake rhythm disturbances .

HY-120355

AP14145	Potassium Channel	Cardiovascular Disease
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits K_Ca2.2 channel and K_Ca channel with IC₅₀ of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect .

HY-P2061

Leualacin	Calcium Channel	Cardiovascular Disease
Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis .

HY-162336

Casein kinase 1δ-IN-15	Casein Kinase	Neurological Disease
Casein kinase 1δ-IN-15 is an inhibitor for casein kinase 1 (CK1δ), with an IC₅₀ of 0.045 μM .

HY-P10290

Neuropeptide Y (human) free acid	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling .

Cat. No.	Product Name	Target	Research Area

HY-112173

Prolylleucine 3 Publications Verification ((Benzyloxy)carbonyl)-L-prolyl-D-leucine	Peptides	Cardiovascular Disease Neurological Disease
Prolylleucine is a dipeptide containing branched-chain amino acids. Prolylleucine can affect the circadian rhythms and behaviour of animals .

HY-P5244

Tripeptide-32	Peptides	Metabolic Disease
Tripeptide-32 is a bioactive peptide that targets the PER1 gene. Tripeptide-32 can regulate circadian rhythms and stimulate the synthesis of cellular repair proteins, with anti-aging activity .

HY-P2061

Leualacin	Calcium Channel	Cardiovascular Disease
Leualacin, a calcium channel blocker, can be isolated from the fungus Hapsidospora irregularis .

HY-P10290

Neuropeptide Y (human) free acid	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-76632

4-Hydroxyisophthalic acid	Apocynaceae Structural Classification Ketones, Aldehydes, Acids Source classification Plants Decalepis hamiltonii Wight & Arn.	Cholinesterase (ChE) SOD
4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies .

HY-B1812

Veratrole 1,2-Dimethoxybenzene	Structural Classification Natural Products Glycine soya Classification of Application Fields Source classification Other Diseases Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields	Cytochrome P450
Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-149101

Riboxin IDP	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Riboxin (IDP), an orally active purine derivative-hypoxanthine rlboside, has antihypoxic and antihyperthermic activity. Riboxin also has an antiarrhythmic action in cats, rabbits, and mice with cardiac rhythm disorders induced by Ouabain. Riboxin protects animals against the noxious effects of γ-irradiation .

HY-B1812R

Veratrole (Standard) 1,2-Dimethoxybenzene (Standard)	Structural Classification Natural Products Glycine soya Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Cytochrome P450
Veratrole (Standard) is the analytical standard of Veratrole. This product is intended for research and analytical applications. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

Cat. No.	Product Name	Chemical Structure

HY-B1812S

Veratrole-d4

Veratrole-d₄ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1751S

Quinidine-d3
Quinidine-d₃ is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.

HY-B1812S3

Veratrole-d6

Veratrole-d₆ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S1

Veratrole-d2

Veratrole-d₂ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S2

Veratrole-d10

Veratrole-d₁₀ is the deuterium labeled Veratrole. Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

HY-B1812S4

Veratrole-d2-1

Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole (1,2-Dimethoxybenzene) is a key compound that widely exists in plants and attracts pollinators. The release of Veratrole has a circadian rhythm and plays an important role in plant reproduction, species differentiation, and interactions with pollinators. In addition, Veratrole can be demethylated by cytochrome P-450 in Streptomyces setonii .

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