reverse-transcription

By Targets:	Reverse Transcriptase (3) Biochemical Assay Reagents (3) DNA/RNA Synthesis (2) Endogenous Metabolite (1) HIV (7) Phosphatase (1)
By Research Areas:	Cancer (2) Infection (7) Inflammation/Immunology (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleotides and their Analogs (2) A (1)

Targets Recommended: Reverse Transcriptase Microphthalmia Associated Transcription Factor (MITF) OLIG2 ATF6 RUNX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)	DNA/RNA Synthesis	Others
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-14267

Lersivirine UK-453061	HIV Reverse Transcriptase	Infection
Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC₅₀=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains .

HY-138657

NCGC00378430 1 Publications Verification	Phosphatase	Cancer
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model .

HY-W013098

2'-Deoxyadenosine 5'-triphosphate disodium 5'-Dexoadenosine triphosphate disodium	Biochemical Assay Reagents
2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

HY-126781

Fozivudine tidoxil BM-211290	HIV DNA/RNA Synthesis	Infection
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-E70403

*Warm-Start M-MLV Reverse* Transcriptase**	Biochemical Assay Reagents	Others
Warm-Start M-MLV Reverse Transcriptase is a reverse transcriptase active below 37°C and can completely release reverse transcription activity at 55°C without affecting cDNA synthesis .

HY-162461

HIV-1 inhibitor-66	Reverse Transcriptase HIV	Infection
HIV-1 inhibitor-66 is an orally active non-nucleoside *reverse transcription* inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type *HIV-1 reverse* transcriptase with an IC₅₀** of 40 nM .

HY-139158

Ainuovirine	HIV	Infection
Ainuovirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI). Ainuovirine inhibits HIV replication by non-competitively binding to HIV reverse transcriptase and blocking the reverse transcription process of viral RNA. Ainuovirine can be used for human immunodeficiency virus (HIV) type 1 infection .

HY-19111

R-82150 TIBO-R 82150	HIV Reverse Transcriptase	Infection
R-82150 (TIBO-R 82150) is an *HIV-1 reverse* transcriptase** inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses .

HY-W008661A

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade	Biochemical Assay Reagents	Others
Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is provided in the form of aqueous solution .

HY-146352

HIV-1 inhibitor-28	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC₅₀ of 58 nM for WT HIV-1 strain and an IC₅₀ of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC₅₀ = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .

HY-120072

PF-3450074 3 Publications Verification PF-74	HIV	Infection
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC₅₀=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.

HY-113137

N2,N2-Dimethylguanosine 3 Publications Verification	Endogenous Metabolite	Cancer
N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. N2,N2-Dimethylguanosine hinders reverse transcriptase-mediated cDNA synthesis and is one of the key modifications that affect sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can selectively remove one of the methyl groups through AlkB mutant enzymes (such as D135S/L118V) and convert it into N2-methylguanosine, thereby reducing the hindrance to reverse transcription .

Cat. No.	Product Name	Type

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)	Gene Sequencing and Synthesis
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-W013098

2'-Deoxyadenosine 5'-triphosphate disodium 5'-Dexoadenosine triphosphate disodium	Enzyme Substrates
2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

2'-Deoxyadenosine 5'-triphosphate disodium

5'-Dexoadenosine triphosphate disodium

Enzyme Substrates

2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

HY-W008661A

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade	Cell Assay Reagents
Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is provided in the form of aqueous solution .

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade

dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade

Cell Assay Reagents

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is one of the raw materials used by DNA polymerase to synthesize long DNA chains during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade (dGTP trisodium,100 mM Solution,PCR Grade) is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is provided in the form of aqueous solution .

Cat. No.	Product Name

HY-K0512

microRNA RT Master Mix for qPCR Ⅲ (poly A)
MCE microRNA RT Master Mix for qPCR Ⅲ (poly A) uses poly(A)-tailing method to perform reverse transcription from miRNA first-strand to cDNA.

HY-K0513

RT Master Mix for qPCR III
MCE MCE Reverse Transcription Kit III is suitable for the conventional synthesis of cDNA from RNA and the stem-loop method for the synthesis of cDNA from microRNA (miRNA).

HY-K0510A

RT Master Mix for qPCR II Maximum Cited Publications 95 Publications Verification
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription. With advanced reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K0511A

RT Master Mix for qPCR II (gDNA digester plus) 25+ Cited Publications
MCE RT Master Mix for qPCR II is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. With updated reverse transcriptase, this kit can synthesize cDNA more rapidly, more specifically.

HY-K0511

RT Master Mix for qPCR (gDNA digester plus) 25+ Cited Publications
MCE RT Master Mix for qPCR (gDNA digester plus) is a convenient, ready-to-use formulation for reverse transcription and can eliminate genomic DNA (gDNA) contaminations in RNA samples. The cDNA product can be directly applied as a template in a standard PCR and real time quantitative PCR (qPCR).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113137

N2,N2-Dimethylguanosine 3 Publications Verification	Structural Classification Natural Products Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. N2,N2-Dimethylguanosine hinders reverse transcriptase-mediated cDNA synthesis and is one of the key modifications that affect sequencing efficiency in high-throughput RNA sequencing. N2,N2-Dimethylguanosine can selectively remove one of the methyl groups through AlkB mutant enzymes (such as D135S/L118V) and convert it into N2-methylguanosine, thereby reducing the hindrance to reverse transcription .

Cat. No.	Product Name		Classification

HY-126781

Fozivudine tidoxil BM-211290		Azide
Fozivudine tidoxil (BM-211290) is an orally active thioether lipid-zidovudine (ZDV) conjugate with anti-HIV activity. Fozivudine tidoxil, a member of the NRTI family of agent, is incorporated into the newly synthesized strand of DNA during intracellular viral replication and irreversibly binds viral RT which disrupts viral reverse-transcription . Fozivudine tidoxil is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-W008661

Deoxyguanosine triphosphate (trisodium) solution (100mM) dGTP (trisodium) solution (100mM); 2'-Deoxyguanosine-5'-triphosphate (trisodium) solution (100mM)		Nucleotides and their Analogs
Deoxyguanosine triphosphate (dGTP) trisodium solution (100mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-W013098

2'-Deoxyadenosine 5'-triphosphate disodium 5'-Dexoadenosine triphosphate disodium		Nucleotides and their Analogs A
2'-Deoxyadenosine 5'-triphosphate disodium (5'-Dexoadenosine triphosphate disodium) is a nucleotide with important biological activities and can serve as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. 2'-Deoxyadenosine 5'-triphosphate disodium plays a key role in DNA synthesis and reverse transcription. 2'-Deoxyadenosine 5'-triphosphate disodium is also widely used in in vitro reactions in molecular biology research.

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reverse-transcription

Inhibitors & Agonists

Biochemical Assay Reagents

MCE Kits

NaturalProducts

Click Chemistry

Oligonucleotides

Natural
Products