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Isoforms Recommended:	Caspase 3

Results for "

pro-caspase-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (7) ADC Cytotoxin (1) Apoptosis (7) Autophagy (1) Bcl-2 Family (1) HDAC (2) Integrin (5) PARP (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (6)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-N5033

17-Hydroxy sprengerinin C	Bcl-2 Family Caspase	Cancer
17-Hydroxy sprengerinin C (compound 10) is a glycoside compound isolated from rhizomes of Polygonatum sibiricum. 17-Hydroxy sprengerinin C possesses stronger anticancer activities. 17-Hydroxy sprengerinin C reduces the expression of Blc-2 and pro-caspase3 and increases the production of Bax .

HY-13523

PAC-1 Maximum Cited Publications 6 Publications Verification procaspase activating compound 1	Caspase Autophagy Apoptosis	Cancer
PAC-1 is a *procaspase-3* activator that induces apoptosis in cancer cells with an EC₅₀ of 2.08 μM.

HY-100472

ZYZ-488	Caspase	Cancer
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 .

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-12290R

Arg-Gly-Asp-Ser (Standard)	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-117614

WF-210	Caspase Apoptosis	Cancer
WF-210 is a potent *procaspase-3* activator with an EC₅₀ value of 0.95 μM. WF-210 induces Apoptosis. WF-210 has anti-tumor activity .

HY-12455

Duocarmycin A	ADC Cytotoxin Apoptosis Caspase	Cancer
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels .

HY-131688

2-Chlorohexadecanoic acid	PARP Caspase	Inflammation/Immunology
2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3 .

HY-142690A

HDAC-IN-27 dihydrochloride	Apoptosis HDAC	Cancer
HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC₅₀ values ranging from 0.43 to 3.01 nM against *HDAC1-3. HDAC-IN-27 dihydrochloride exhibits both in vivo* and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia (AML) .

HY-142690

HDAC-IN-27	HDAC Apoptosis	Cancer
HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC₅₀ values ranging from 0.43 to 3.01 nM against *HDAC1-3. HDAC-IN-27 exhibits both in vivo* and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML) .

Cat. No.	Product Name	Target	Research Area

HY-P1740

RGD peptide (GRGDNP) 5 Publications Verification	Integrin Apoptosis Caspase	Inflammation/Immunology
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-P1740A

RGD peptide (GRGDNP) (TFA) 5 Publications Verification	Integrin Apoptosis	Inflammation/Immunology Cancer
RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation ^[3].

HY-12290

Arg-Gly-Asp-Ser 5 Publications Verification RGDS peptide; Fibronectin tetrapeptide	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

HY-12290A

Arg-Gly-Asp-Ser TFA RGDS peptide TFA; Fibronectin tetrapeptide TFA	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (TFA) is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser (TFA) directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1 .

HY-12290R

Arg-Gly-Asp-Ser (Standard)	Integrin	Inflammation/Immunology
Arg-Gly-Asp-Ser (Standard) is the analytical standard of Arg-Gly-Asp-Ser. This product is intended for research and analytical applications. Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. Arg-Gly-Asp-Ser directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1.

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P79267

	Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) caspase-3; CASP3; Apopain; Cysteine protease CPP32; CPP-32; protein Yama; SREBP cleavage activity 1; SCA-1; CPP32	Human	E. coli
	Pro-Caspase-3/Pro-CASP3 Protein, Human (277a.a, His) is the recombinant human-derived Caspase-3/CASP3, expressed by E. coli , with N-His labeled tag.

HY-P72874

	Caspase-3/CASP3 Protein, Human (His) caspase-3; CASP-3; CPP-32; SCA-1; YAMA	Human	E. coli
	Caspase-3/CASP3 protein is critical in the execution of apoptosis, cleaving PARP1 and activating SREBP, caspase-6, -7 and -9, initiating the cascade leading to apoptosis. In addition to apoptosis, it regulates cell adhesion, promotes inflammation, inhibits AKT1 in oxidative stress, and modulates antiviral responses by cleaving proteins such as CGAS, IRF3, and MAVS. Caspase-3/CASP3 Protein, Human (His) is the recombinant human-derived Caspase-3/CASP3 protein, expressed by E. coli , with C-His labeled tag.

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