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prazosin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (18) Autophagy (2) BCRP (1) Drug Derivative (1) Isotope-Labeled Compounds (2) P-glycoprotein (1) Reference Standards (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (11) Endocrinology (8) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (3)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0193

*Prazosin* Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease .

HY-B0193AS

Prazosin-d8 hydrochloride	Adrenergic Receptor Isotope-Labeled Compounds	Neurological Disease
Prazosin-d8 hydrochloride is the deuterium labeled Prazosin hydrochloride. Prazosin hydrochloride is an alpha-adrenergic blocker .

HY-B0193A

Prazosin hydrochloride Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM ^[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively .

HY-B0193S

Prazosin-d8	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin-d₈ is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-D1606

BODIPY FL prazosin	Adrenergic Receptor	Metabolic Disease
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with K_i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes .

HY-108347

CP-100356 hydrochloride 5+ Cited Publications	P-glycoprotein BCRP	Metabolic Disease
CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC₅₀s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC₅₀=∼66 µM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC₅₀>15 µM) .

HY-B0193R

Prazosin (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease Endocrinology
Prazosin (Standard) is the analytical standard of Prazosin. This product is intended for research and analytical applications. 0

HY-B0193AR

Prazosin hydrochloride (Standard)	Reference Standards Adrenergic Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Prazosin (hydrochloride) (Standard) is the analytical standard of Prazosin (hydrochloride). This product is intended for research and analytical applications. Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC₅₀ of 0.15 nM ^[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC₅₀s of 1.8, and 13 μM, respectively .

HY-106554

Trimazosin	Adrenergic Receptor	Cardiovascular Disease
Trimazosin is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenoceptors .

HY-106554A

Trimazosin hydrochloride hydrate	Adrenergic Receptor	Cardiovascular Disease
Trimazosin hydrochloride hydrate is an orally active, quinazoline derivative which is structurally related to prazosin. Trimazosin shows hypotensive effect by selectively block α1-adrenergic receptor .

HY-111188

A55453	Adrenergic Receptor	Others
A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. ^125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .

HY-101045

AT-112	Drug Derivative	Cardiovascular Disease
AT-112 is a ketotanserin analogue. AT-112 has hemodynamic effects. AT-112 significantly reduces portal vein branch blood flow and portal vein pressure. AT-112 can be used to study the pathogenesis of portal hypertension .

HY-B1298A

Methoxamine	Adrenergic Receptor	Cardiovascular Disease
Methoxamine is a selective alpha1-adrenergic receptor agonist. Methoxamine causes vasoconstriction and increased peripheral vascular resistance . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .

HY-B1298

Methoxamine hydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance . Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery .

HY-118335

Prazobind SZL 49	Adrenergic Receptor	Cardiovascular Disease
Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure .

HY-118335S

Prazobind-d8 SZL 49-d8	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Prazobind-d₈ is the deuterium labeled Prazobind (HY-118335). Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure .

HY-123311

CP59430	Adrenergic Receptor	Endocrinology
CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α₁-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α₁-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization .

HY-19279A

JTH-601 free base	Adrenergic Receptor	Endocrinology
JTH-601 Free base is a novel alpha1-adrenoceptor antagonist that exhibits potent activity in inhibiting phenylephrine-induced contractions in lower urinary tract tissues. JTH-601 Free base competitively antagonizes alpha1-adrenoceptor-mediated contractile responses, demonstrating greater potency than prazosin or tamsulosin. JTH-601 Free base is anticipated to be effective in treating urinary outlet obstruction associated with benign prostatic hyperplasia.

HY-106954

Upidosin Rec 15/2739; Recordati 15/2739; SB 216469	Adrenergic Receptor	Inflammation/Immunology
Upidosin (Rec 15/2739) is an α-1 adrenoceptor (α-1 AR) antagonist. Upidosin shows moderate selectivity for the α-1A AR subtype. Upidosin shows uroselectivity in urethra and prostate with a K_b value of 2-3 nM higher than in ear artery and aorta with a K_b value of 20-100 nM. Upidosin inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptor. Upidosin can be used for the research of urethral obstruction .

HY-136693

L-654284	Adrenergic Receptor	Neurological Disease
L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows K_i values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a K_i of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .

Cat. No.	Product Name	Type

HY-D1606

BODIPY FL prazosin	Fluorescent Dyes/Probes
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with K_i values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0193

*Prazosin* 10+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease .

Cat. No.	Product Name	Chemical Structure

HY-B0193AS

Prazosin-d8 hydrochloride
Prazosin-d8 hydrochloride is the deuterium labeled Prazosin hydrochloride. Prazosin hydrochloride is an alpha-adrenergic blocker .

HY-B0193S

Prazosin-d8
Prazosin-d₈ is the deuterium labeled Prazosin. Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

HY-118335S

Prazobind-d8
Prazobind-d₈ is the deuterium labeled Prazobind (HY-118335). Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC₅₀ of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure .

Cat. No.	Product Name		Classification

HY-123311

CP59430		Azide
CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α₁-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α₁-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization .

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prazosin

Inhibitors & Agonists

Fluorescent Dye

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products