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Results for "

photoswitchable

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W106234
    4-(Phenyldiazenyl)benzoic acid

    		TRP Channel Others
    4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used as pharmacological tools for study of pain signaling.
    4-(Phenyldiazenyl)benzoic acid
  • HY-149459A
    Phototrexate

    (E)-azoMTX

    		 Dihydrofolate reductase (DHFR) Cancer
    Phototrexate is a photoswitchable inhibitor of the human dihydrofolate reductase (DHFR). Phototrexate has antifolate and antiproliferative properties, which can be used for the research of cancer .
    Phototrexate
  • HY-N15783
    Photoswitchable sphingosine

    		Biochemical Assay Reagents Others
    Photoswitchable Sphingosine is a photoswitchable lipid. Photoswitchable sphingosine can be used to study the translation of optical stimuli into a reversible cellular response .
    Photoswitchable sphingosine
  • HY-110209
    AC4

    		TRP Channel Others
    AC4 is a trans antagonist upon voltageactivation of TRPV1 and as cis antagonist of TRPV1 currents upon stimulation with Capsaicin (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert .
    AC4
  • HY-N15782
    18:0-PhoDAG

    		TRP Channel Neurological Disease
    18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that allows rapid photoactivation of these DAG-sensitive TRP channels .
    18:0-PhoDAG
  • HY-126748
    VUF14862

    		Histamine Receptor Others
    VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling .
    VUF14862
  • HY-163445
    NAMPT activator-6

    		NAMPT Cancer
    NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation .
    NAMPT activator-6
  • HY-139904
    TRPA1 Antagonist 3

    		TRP Channel Others
    TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel.
    TRPA1 Antagonist 3
  • HY-160209
    KIO-301

    		HCN Channel Cardiovascular Disease
    KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa .
    KIO-301
  • HY-126424
    OptoDArG

    		Fluorescent Dye Others
    OptoDArG is a photoswitchable probe that has the activity to recognize lipid-gated pores by controlling TRPC3 channels and can be used as a tool to study the lipid sensing mechanism of TRPC channels.
    OptoDArG
  • HY-N15781
    Trans-faazo-4

    		Biochemical Assay Reagents Metabolic Disease
    Trans-FAAzo-4 is a photo-switchable fatty acid analogue used in photo-pharmacology. Trans-FAAzo-4 is able to alter membrane lateral pressure and thus control opening and closing of mechanosensitive ion channels .
    Trans-faazo-4
  • HY-161092A
    KIO-301 chloride hydrochloride

    		HCN Channel Potassium Channel Neurological Disease
    KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .
    KIO-301 chloride hydrochloride
  • HY-161897
    CENP-E-IN-2

    		Kinesin Cancer
    CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC50 of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity .
    CENP-E-IN-2
  • HY-161414
    trans-VUF25471

    		CXCR Others
    trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .
    trans-VUF25471
  • HY-125667
    PA1

    Photoamiloride-1

    		 Sodium Channel Metabolic Disease
    PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively .
    PA1
  • HY-110358
    QAQ dichloride

    		Sodium Channel Inflammation/Immunology
    QAQ dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .
    QAQ dichloride
  • HY-110358A
    QAQ

    		Sodium Channel Inflammation/Immunology
    QAQ dichloride dichloride, a photoswitchable voltage-gated Nav and Kv channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .
    QAQ

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