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79

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1

Fluorescent Dye

1

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10

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-77817
    Pyrrole-2-carboxaldehyde

    2-Formylpyrrole

    		 Biochemical Assay Reagents Others
    Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .
    Pyrrole-2-carboxaldehyde
  • HY-N8487
    7-Methoxyflavone

    		Others Neurological Disease Inflammation/Immunology
    7-Methoxyflavone is a compound isolated from Zornia brasiliensis. 7-Methoxyflavone has peripheral antinociceptive activity. 7-Methoxyflavone inhibits paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase .
    7-Methoxyflavone
  • HY-168620
    CDK6-IN-1

    		CDK Cancer
    CDK6-IN-1 (compound 4i) is a CDK6 inhibitor. CDK6-IN-1 inhibits cell growth and induces cell cycle arrest at G1-phase .
    CDK6-IN-1
  • HY-N8287
    Oxaline

    		Microtubule/Tubulin Cancer
    Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase .
    Oxaline
  • HY-N10394
    Metachromins X

    		Others Cancer
    Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .
    Metachromins X
  • HY-163153
    Anticancer agent 184

    		Apoptosis Cancer
    Anticancer agent 184 (Compound 6o) is a novel, effective and low toxic anticancer drug. Anticancer agent 184 induces apoptosis by blocking the S phase .
    Anticancer agent 184
  • HY-170464
    PChemsPC

    1-Palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

    		 Biochemical Assay Reagents Others
    PChemsPC (1-Palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine) is a sterol-lipid that robustly demixes into micron-scale, liquid phases .
    PChemsPC
  • HY-155413
    Antiproliferative agent-43

    		Apoptosis Cancer
    Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase .
    Antiproliferative agent-43
  • HY-135325R
    4-Hydroxyacetophenone oxime (Standard)

    		Drug Metabolite Inflammation/Immunology
    Pyrrole-2-carboxaldehyde (Standard) is the analytical standard of Pyrrole-2-carboxaldehyde. This product is intended for research and analytical applications. Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .
    4-Hydroxyacetophenone oxime (Standard)
  • HY-77817R
    Pyrrole-2-carboxaldehyde (Standard)

    		Others Others
    Pyrrole-2-carboxaldehyde (Standard) is the analytical standard of Pyrrole-2-carboxaldehyde. This product is intended for research and analytical applications. Pyrrole-2-carboxaldehyde has vibrational and electronic characteristics used to establish the existence of dimeric form in solid phase and monomeric form in solution phase .
    Pyrrole-2-carboxaldehyde (Standard)
  • HY-123369
    BMI-1026

    		CDK Apoptosis Cancer
    BMI-1026 is a cyclin-dependent kinase 1 (Cdk1) inhibitor with IC50 of 2.3 nM. BMI-1026 induces apoptosis by arresting the G2-M phase .
    BMI-1026
  • HY-126423
    Isorhamnetin 3-glucuronide

    Isorhamnetin 3-O-glucuronide

    		 Apoptosis Cancer
    Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .
    Isorhamnetin 3-glucuronide
  • HY-147748
    COX-2-IN-17

    		COX Inflammation/Immunology
    COX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase .
    COX-2-IN-17
  • HY-110111
    T2AA
    1 Publications Verification

    		 DNA/RNA Synthesis Cancer
    T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
    T2AA
  • HY-119407
    Terpendole E

    		Kinesin Cancer
    Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase .
    Terpendole E
  • HY-122151
    MPT0B002

    		Microtubule/Tubulin Apoptosis Cancer
    MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase .
    MPT0B002
  • HY-163808
    Anticancer agent 237

    		Apoptosis Cancer
    Anticancer agent 237 (compound 13) is a potent anticancer agent. Anticancer agent 237 shows cytotoxicity. Anticancer agent 237 induces apoptosis and cell cycle arrest at the S and G2/M phases .
    Anticancer agent 237
  • HY-162938
    Skp2 inhibitor 3

    		E1/E2/E3 Enzyme Cancer
    Skp2 inhibitor 3 (E35), an antitumor agent, is a potent S‑Phase Kinase-associated Protein 2 (SKP2) inhibitor, with an IC50 of 4.86 μM for Skp2-Cks1 binding. Skp2 inhibitor 3 (E35) significantly inhibits colony formation and migration, as well as arrests the cell cycle at the S-phase .
    Skp2 inhibitor 3
  • HY-161339
    SIRT2-IN-13

    		Apoptosis Sirtuin Cancer
    SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase .
    SIRT2-IN-13
  • HY-162447
    P-gp inhibitor 22

    		P-glycoprotein Apoptosis Cancer
    P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase .
    P-gp inhibitor 22
  • HY-149530
    EGFR-IN-86

    		EGFR Apoptosis Cancer
    EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase .
    EGFR-IN-86
  • HY-162416
    CDK7-IN-27

    		CDK Cancer
    CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase .
    CDK7-IN-27
  • HY-161891
    EGFR/Akt-IN-1

    		EGFR Akt Cancer
    EGFR/Akt-IN-1 (compound 17) is a potent inhibitor of EGFR/Akt, with the IC50s of 12.89 μM and 10.88 μM in A549 cells, respectively. EGFR/Akt-IN-1 arrestes the cell cycle at the S phase .
    EGFR/Akt-IN-1
  • HY-155314
    Tubulin polymerization-IN-50

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC50 of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase .
    Tubulin polymerization-IN-50
  • HY-152099
    Antiproliferative agent-19

    		Apoptosis Cancer
    Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase .
    Antiproliferative agent-19
  • HY-146188
    Topoisomerase II inhibitor 8

    		Topoisomerase Cancer
    Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC50 of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase .
    Topoisomerase II inhibitor 8
  • HY-147896
    Tubulin polymerization-IN-29

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-29 (compound 6g) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-29 exhibits potent antiproliferative activity. Tubulin polymerization-IN-29 can induce HeLa cells arrest in G2/M phase .
    Tubulin polymerization-IN-29
  • HY-146423
    PROTAC EGFR degrader 6

    		PROTACs EGFR Apoptosis Cancer
    PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFR Del19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase .
    PROTAC EGFR degrader 6
  • HY-155439
    FAK-IN-14

    		FAK Cancer
    FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC50 value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis and arrest the cell at the G2/M phase .
    FAK-IN-14
  • HY-147895
    PCAF-IN-2

    		Histone Acetyltransferase Apoptosis Cancer
    PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC50 value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase .
    PCAF-IN-2
  • HY-144738
    Dual FAAH/sEH-IN-1

    		Epoxide Hydrolase FAAH Inflammation/Immunology
    Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase .
    Dual FAAH/sEH-IN-1
  • HY-121512
    SK-7041

    		HDAC Apoptosis Cancer
    SK-7041 is a HDAC inhibitor with the IC50 of 172 nM. SK-7041 induces the hyperacetylation of histones H3 and H4 .SK-7041 inhibits tumor cell growth in vivo and in vitro, induces cell apoptosis, and arrests cell cycle at the G1 phase .
    SK-7041
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-161146
    EGFR-IN-100

    		EGFR Apoptosis Cancer
    EGFR-IN-100 (compound 3f) is a EGFR inhibitor with IC50 range of 0.137-0.507 μM. EGFR-IN-100 has antiproliferative activity and induces the apoptosis pathway. EGFR-IN-100 arrests the MCF-7 cell cycle at the S phase .
    EGFR-IN-100
  • HY-143266
    Topoisomerase I inhibitor 3

    		Topoisomerase Apoptosis Cancer
    Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .
    Topoisomerase I inhibitor 3
  • HY-151756
    diSulfo-Cy3 alkyne

    		Fluorescent Dye Others
    diSulfo-Cy3 alkyne is a water-soluble dye and a Click Chemistry reagent containing an alkyne group. Absorbance and emission of the dye are identical to Cy3 fluorophore. diSulfo-Cy3 alkyne can be used for the labeling of proteins, and even intact biological objects in water phase .
    diSulfo-Cy3 alkyne
  • HY-146422
    PROTAC EGFR degrader 5

    		PROTACs EGFR Apoptosis Cancer
    PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFR Del19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase .
    PROTAC EGFR degrader 5
  • HY-144340
    Antitumor agent-43

    		DNA/RNA Synthesis Apoptosis Cancer
    Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC50of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase .
    Antitumor agent-43
  • HY-163622
    USP10-IN-3

    		Apoptosis Cancer
    USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase .
    USP10-IN-3
  • HY-163722
    EGFR/DHFR-IN-1

    		EGFR Dihydrofolate reductase (DHFR) Cancer
    EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR with IC50s of 0.151 and 0.541 µM, respectively. EGFR/DHFR-IN-1 arrests the cell cycle at both G0-G1 and S phases .
    EGFR/DHFR-IN-1
  • HY-150048
    BK50164

    		CD73 Apoptosis Cancer
    BK50164 is a potent CD73 inhibitor with an IC50 value of 13.089 µM. BK50164 binds to CD99 with a KD value of 1.5 µM. BK50164 shows antiproliferative activity. BK50164 induced Apoptosis and cell cycle arrest at Sub-G1 phase .
    BK50164
  • HY-N0662
    Amentoflavone
    5+ Cited Publications

    Didemethyl-ginkgetin

    		 Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor Infection Neurological Disease Inflammation/Immunology Cancer
    Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .
    Amentoflavone
  • HY-146409
    Antitumor agent-59

    		Apoptosis Cancer
    Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase .
    Antitumor agent-59
  • HY-149024
    VEGFR-2-IN-23

    		VEGFR Apoptosis MDM-2/p53 Cancer
    VEGFR-2-IN-23 (compound 11b) is a potent and selective VEGFR-2 inhibitor with an IC50 value of 0.34 nM. VEGFR-2-IN-23 shows antitumor activity. VEGFR-2-IN-23 induces apoptosis and cell cycle arrest at G1 phase .
    VEGFR-2-IN-23
  • HY-146093
    Antitumor agent-62

    		Apoptosis Cancer
    Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase .
    Antitumor agent-62
  • HY-150004
    c-Met/HDAC-IN-3

    		c-Met/HGFR HDAC Apoptosis Cancer
    c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase .
    c-Met/HDAC-IN-3
  • HY-158233
    Apoptotic agent-4

    		Apoptosis VEGFR Cancer
    Apoptotic agent-4 (Compound 9) is a apoptosis inducer. Apoptotic agent-4 inhibits VEGFR-2 with an IC50 of 0.5717 μM. Apoptotic agent-4 inhibits cancer cell proliferation and arrests the cell at both the G2/M and Pre-G1 phases .
    Apoptotic agent-4
  • HY-143272
    FGFR1 inhibitor-6

    		FGFR Cancer
    FGFR1 inhibitor-6 is a potent FGFR1 inhibitor with an IC50 value of 16.31 nM. FGFR1 inhibitor-6 shows cytotoxic activities. FGFR1 inhibitor-6 induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase .
    FGFR1 inhibitor-6
  • HY-146666
    STAT3-IN-9

    		Apoptosis STAT Cancer
    STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase .
    STAT3-IN-9
  • HY-155685
    SA-VA

    		PROTACs VEGFR Ephrin Receptor Apoptosis Cancer
    SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
    SA-VA

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