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peptide coupling reactions

" in MedChemExpress (MCE) Product Catalog:

14

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5

Biochemical Assay Reagents

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1

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W008558
    Fmoc-N-Me-Leu-OH

    		Amino Acid Derivatives Others
    Fmoc-N-Me-Leu-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction.
    Fmoc-N-Me-Leu-OH
  • HY-W010986
    Fmoc-N-Me-Phe-OH

    		Drug Intermediate Others
    Fmoc-N-Me-Phe-OH is an N-methylated amino acid that can be used for the synthesis of some active compounds .
    Fmoc-N-Me-Phe-OH
  • HY-Y1666
    2,2′-Dipyridyl disulfide

    		Biochemical Assay Reagents Others
    2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers .
    2,2′-Dipyridyl disulfide
  • HY-W008235
    Fmoc-N-Me-Ala-OH

    		Amino Acid Derivatives Drug Intermediate Cancer
    Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction. Fmoc-N-Me-Ala-OH is a drug intermediate that can be used to synthesize ML-IAP Lys-covalent inhibitor .
    Fmoc-N-Me-Ala-OH
  • HY-D0177
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

    Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

    		 Biochemical Assay Reagents Others
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) is a peptide coupling reagent and BOP analog. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate promotes the reaction of amino and carboxyl groups to form peptide bonds. (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate can be used in the synthesis of peptide compounds
    (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
  • HY-107783
    Sulfo-GMBS

    		Others Cancer
    Sulfo-GMBS is a cross-linking agent widely used in chemical modification and coupling reactions of proteins and peptides. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .
    Sulfo-GMBS
  • HY-120286
    K-13

    		Drug Intermediate Others
    K-13 is a cyclic peptide compound synthesized by a specific organozinc reagent. Its synthesis process involves intermolecular and intramolecular Negishi cross-coupling reactions and is one of the shortest routes reported for the synthesis of such cyclic peptides.
    K-13
  • HY-174961C
    Fmoc-PEG-Maleimide (MW 5000)

    Fmoc-NH-PEG-Mal (MW 5000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 5000) (Fmoc-NH-PEG-Mal (MW 5000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 5000)
  • HY-174961B
    Fmoc-PEG-Maleimide (MW 3400)

    Fmoc-NH-PEG-Mal (MW 3400)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 3400) (Fmoc-NH-PEG-Mal (MW 3400)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 3400)
  • HY-174961
    Fmoc-PEG-Maleimide (MW 1000)

    Fmoc-NH-PEG-Mal (MW 1000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 1000) (Fmoc-NH-PEG-Mal (MW 1000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 1000)
  • HY-174961A
    Fmoc-PEG-Maleimide (MW 2000)

    Fmoc-NH-PEG-Mal (MW 2000)

    		 Biochemical Assay Reagents Others
    Fmoc-PEG-Maleimide (MW 2000) (Fmoc-NH-PEG-Mal (MW 2000)) is a PEG derivative with an Fmoc protecting group and a Maleimide (HY-W007324) reactive group. Fmoc is a commonly used amino protecting group that protects the amino group from unwanted reactions until it is removed for a specific coupling reaction. Maleimide forms a stable thioether bond with sulfhydryl (-SH) groups. PEG modification can improve solubility and stability and reduce the immunogenicity of proteins and peptides .
    Fmoc-PEG-Maleimide (MW 2000)
  • HY-118112
    4-N-Maleimidobenzoicacid-NHS

    		Biochemical Assay Reagents Others
    4-N-Maleimidobenzoicacid-NHS is a PEG linker that finds utility in bioconjugation endeavors and protein labeling ventures. Specifically designed for selective reaction with thiol groups, the maleimide group establishes covalent linkages, thereby facilitating the coupling of proteins, peptides, or diverse molecules to thiol-bearing biomolecules. The NHS ester is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic conditions to form a covalent bond.
    4-N-Maleimidobenzoicacid-NHS
  • HY-100138
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)

    		Radionuclide-Drug Conjugates (RDCs) ADC Linker Cancer
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
    2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)
  • HY-151782
    H-(Gly)3-Lys(N3)-OH

    		ADC Linker Others
    The azide function is widely used for coupling to alkyne-containing fragments via the renowned Click reaction. Polyglycine fragments containing up to 7 glycines are reported to bind to surfaces and have potential application in nanotechnology constructs: constructs of Gly7-NHCH2-fragment containing peptides bind on mica surface in aqueous solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-(Gly)3-Lys(N3)-OH

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