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p44/42

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (2) GnRH Receptor (1) LPL Receptor (2) MAPKAPK2 (MK2) (1) Neuropeptide Y Receptor (2) Phosphodiesterase (PDE) (1) YAP (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (3) Infection (1) Metabolic Disease (2) Neurological Disease (4)

8

Inhibitors & Agonists

1

Peptides

2

Antibodies

Targets Recommended: Cdc42-binding kinase Ack1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BIIE-0246 1 Publications Verification AR-H 053591	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC₅₀ value of 15 nM for rat [ ¹²⁵I]PYY_3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy .

BIIE-0246 hydrochloride 1 Publications Verification AR-H 053591 hydrochloride	Neuropeptide Y Receptor	Metabolic Disease
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC₅₀ value of 15 nM for rat [ ¹²⁵I]PYY_3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy .

Ki16425 Maximum Cited Publications 9 Publications Verification Debio 0719	LPL Receptor YAP	Neurological Disease Cancer
Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with K_is of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

Olodanrigan 3 Publications Verification EMA401; PD-126055; (S)-EMA400	Angiotensin Receptor	Cardiovascular Disease Neurological Disease Endocrinology
Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .

(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH	GnRH Receptor	Others
(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Quazinone Ro 13-6438; Ro 13-6438/006	Phosphodiesterase (PDE) MAPKAPK2 (MK2)	Infection
Quazinone is a selective inhibitor of cGMP-inhibited-phosphodiesterase (cGI-PDE, PDE3). Quazinone inhibits the phosphorylation of p42/p44 MAP kinase. Quazinone possesses antimitogenic effect .

Olodanrigan sodium EMA401 sodium; PD-126055 sodium	Angiotensin Receptor	Neurological Disease Endocrinology
Olodanrigan (EMA401) sodium is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. Olodanrigan sodium is under development as a neuropathic pain therapeutic agent. Olodanrigan sodium analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons .

Ki16425 (Standard)	LPL Receptor YAP	Neurological Disease Cancer
Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK . Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells .

Cat. No.	Product Name	Target	Research Area

(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH	GnRH Receptor	Others
(Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Cat. No.	Compare	Product Name	Application	Reactivity

	*Phospho-p44/42* MAPK(Erk1/2)(Thr202/Tyr204) Antibody (YA5321)** ERK 1; ERK 2; ERK-2; ERK1; erk1/2; ERK2; ERT1; ERT2; Extracellular signal regulated kinase 1; Extracellular signal regulated kinase 1	WB	Human, Mouse
	Phospho-p44/42 MAPK(Erk1/2)(Thr202/Tyr204) Antibody (YA5321) is a mouse-derived and non-conjugated monoclonal antibody, targeting to p44/42 MAPK (Erk1/2) (Thr202/Tyr204). It can be applicated for WB assays, in the background of human, mouse.

	p44/42 MAPK (Erk1/2) Antibody (YA3934) ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rabbit
	p44/42 MAPK (Erk1/2) Antibody (YA3934) is a mouse-derived and non-conjugated IgG2b antibody, targeting to p44/42 MAPK (Erk1/2). It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, rabbit.

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