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oxidation sensitive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Biochemical Assay Reagents (1) Drug Metabolite (2) Fluorescent Dye (1) Glucocorticoid Receptor (1) Guanylate Cyclase (1) Keap1-Nrf2 (1) Liposome (1) Parasite (1) Prostaglandin Receptor (1)
By Research Areas:	Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Oligonucleotides

Targets Recommended: VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142989

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine	Liposome	Others
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs .

HY-78237

Nelociguat 1 Publications Verification BAY60-4552	Guanylate Cyclase	Cardiovascular Disease
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.

HY-W099331

Monoethylglycinexylidide hydrochloride MEGX hydrochloride; Norlidocaine hydrochloride	Drug Metabolite	Metabolic Disease Inflammation/Immunology
Monoethylglycinexylidide (MEGX) hydrochloride is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver. Monoethylglycinexylidide has proven to be a highly sensitive indicator of hepatic dysfunction, especially in the field of liver transplantation .

HY-W007359

Thiomorpholine	Biochemical Assay Reagents	Others
Thiomorpholine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Thiomorpholine can be used to synthesize quinolines when coupled with bromide. Thiomorpholine can form polymer derivatives that are studied as oxidative sensitive materials and as hemocompatible materials .

HY-D2339

H-FluNox	Fluorescent Dye	Others
H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λ_ex=490 nm, λ_em=535 nm)

HY-125360

Mazipredone free base	Glucocorticoid Receptor	Inflammation/Immunology
Mazipredone free base, a glucocorticoid derivative, is an anti-inflammatory and anti-allergic agent. Mazipredone free base is sensitive to oxidation, acidic and basic media .

HY-W740628

Nicorandil pyridine oxide	Drug Metabolite	Neurological Disease
Nicorandil pyridine oxide is a metabolite of the sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (SUR2B/Kir6.2) activator and nitric oxide donor Nicorandil.

HY-137119A

8,12-iso-iPF2α-VI	Prostaglandin Receptor	Others
8,12-iso-iPF2α-VI is a F2-isoprostanes. 8,12-iso-iPF2α-VI is a sensitive and specific marker of in vivo lipid peroxidation. 8,12-iso-iPF2α-VI can be used as a biomarker of oxidative damage in alzheimer's disease .

HY-149246

Aβ-IN-6	Amyloid-β Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research .

HY-174343

ELQ-121	Parasite	Infection
ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (Q_O)-site of parasites. ELQ-121 has IC₅₀ of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC₅₀ below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC₅₀ of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research .

Cat. No.	Product Name	Type

HY-D2339

H-FluNox	Fluorescent Dyes/Probes
H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λ_ex=490 nm, λ_em=535 nm)

Cat. No.	Product Name	Type

HY-142989

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine	Drug Delivery
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs .

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine

Drug Delivery

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs .

HY-W007359

Thiomorpholine	Biochemical Assay Reagents
Thiomorpholine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Thiomorpholine can be used to synthesize quinolines when coupled with bromide. Thiomorpholine can form polymer derivatives that are studied as oxidative sensitive materials and as hemocompatible materials .

Cat. No.	Product Name		Classification

HY-142989

1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine		Phospholipids
1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that is a constituent of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs) in a molar ratio of 1.5:1.5:1:1 with 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol, and l-α-phosphatidylserine. PERLs can reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and reduce HIV-1 particle secretion from HIV-1 infected PBMCs .

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