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ortho

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Amino Acid Derivatives (1) Biochemical Assay Reagents (1) Cannabinoid Receptor (1) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (1) Ferroptosis (2) Fluorescent Dye (2) Glutathione Peroxidase (2) Insecticide (1) Isotope-Labeled Compounds (2) LDLR (2) NO Synthase (1) Opioid Receptor (1) P-selectin (1) Reactive Oxygen Species (ROS) (3) β-glucuronidase (1)
By Research Areas:	Cardiovascular Disease (4) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144577S

Ortho-hydroxy atorvastatin-d5 calcium	Isotope-Labeled Compounds	Others
Ortho-hydroxy atorvastatin-d₅ calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577) . Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589) .

HY-15626

ortho-iodoHoechst 33258 2 Publications Verification	Fluorescent Dye	Others
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-107848

DL-O-Tyrosine NSC 72345; ortho-tyrosine; o-DL-Tyrosine; o-Tyrosine	Amino Acid Derivatives	Others
DL-O-Tyrosine is a tyrosine derivative .

HY-W015600

2-Acetamidophenol orthocetamol	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-158857

ortho-CBNQ o-Cannabinolquinone; ortho-Cannabinolquinone; o-CBNQ	Cannabinoid Receptor	Neurological Disease
ortho-CBNQ (o-Cannabinolquinone) is an oxidative byproduct of Cannabidiol.

HY-W318448

Ortho-fluoro 4-ANBP	Drug Intermediate	Neurological Disease
Ortho-fluoro 4-ANBP is an opioids analogue, which is an intermediate in the synthesis of N-benzyl ortho-fluoro norfentanyl .

HY-131496S

ortho-Topolin riboside-d4	Isotope-Labeled Compounds	Others
ortho-Topolin riboside-d₄ is deuterium labeled ortho-Topolin riboside .

HY-150341

Ortho-methyl 4-anilino-1-boc-piperidine	Opioid Receptor	Neurological Disease
Ortho-methyl 4-anilino-1-boc-piperidine is a precursor in the synthesis of a compound.

HY-D0234

o-Cresolphthalein ortho-Cresolphthalein	Endogenous Metabolite	Others
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-136346S

Ortho-hydroxy atorvastatin lactone-d5	Drug Metabolite	Cardiovascular Disease
Ortho-hydroxy atorvastatin lactone-d₅ is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .

HY-W015600R

2-Acetamidophenol (Standard) orthocetamol (Standard)	Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS) LDLR	Cardiovascular Disease Inflammation/Immunology
2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC₅₀s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe ²⁺), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-D2286

HBT-Fl-BnB	Fluorescent Dye	Others
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

HY-W134422

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 1 Publications Verification Polyoxyethylene octylphenol ether	Biochemical Assay Reagents	Others
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene?glycol X-114 is a complex of three molecules formed by ortho-, meta-, and para-substitution of the benzene ring.

HY-148964

Thiotraniliprole HY366	Insecticide	Others
Thiotraniliprole (HY366) is an ortho formamidobenzamide insecticide that can be used for the synthesis of insecticidal combinations. Thiotraniliprole has potential applications in the prevention of lepidoptera pests, coleoptera pests, ants, and termites .

HY-W345885

Saccharic acid	β-glucuronidase	Metabolic Disease
Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice .

HY-146332

Collagen-IN-1	P-selectin	Cardiovascular Disease
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC₅₀ value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen-IN-1 has the potential for platelet-related thrombosis diseases research .

HY-16094

Bethanidine sulfate BW 467C60	Adrenergic Receptor	Neurological Disease
Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neurone blockers with sympathomimetic effects similar to bretylium and guanethidine in various animal models, particularly in cats. They inhibit the release of noradrenaline during nerve stimulation and enhance smooth muscle responses to adrenaline and noradrenaline. Bethanidine sulfate increases pressor responses to tyramine, though this effect diminishes with higher doses. Unlike guanethidine, Bethanidine sulfate does not deplete pressor amine content in the iris of cats post-administration. It also briefly inhibits autonomic cholinergic mechanisms and causes temporary neuromuscular paralysis in large doses, contrasting with its prolonged adrenergic neurone blocking effects .

HY-W753779

8-Hydroxygenistein 8-OHG	Reactive Oxygen Species (ROS) NO Synthase	Others
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O₂⁻). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein (HY-14596). The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.

Cat. No.	Product Name	Type

HY-15626

ortho-iodoHoechst 33258 2 Publications Verification	DNA Stain
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

ortho-iodoHoechst 33258

2 Publications Verification

DNA Stain

ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .

HY-D2286

HBT-Fl-BnB	Fluorescent Dyes/Probes
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

Cat. No.	Product Name	Type

HY-W134422

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol X-114 1 Publications Verification Polyoxyethylene octylphenol ether	Surfactants
(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene?glycol X-114 is a complex of three molecules formed by ortho-, meta-, and para-substitution of the benzene ring.

HY-D0234

o-Cresolphthalein ortho-Cresolphthalein	Biochemical Assay Reagents
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

DL-O-Tyrosine NSC 72345; ortho-tyrosine; o-DL-Tyrosine; o-Tyrosine	Amino Acid Derivatives	Others
DL-O-Tyrosine is a tyrosine derivative .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107848

DL-O-Tyrosine NSC 72345; ortho-tyrosine; o-DL-Tyrosine; o-Tyrosine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Amino Acid Derivatives
DL-O-Tyrosine is a tyrosine derivative .

HY-W345885

Saccharic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	β-glucuronidase
Saccharic acid is a competitive inhibitor of β-glucuronidase. Saccharic acid considerably retards hydrolysis of the glucuronide of 'l-ortho-hydroxyphenylazo-2-naph-thol' by frozen mouse kidney sections, but has no effect on liver regeneration following damage and on growth in infant mice .

HY-W753779

8-Hydroxygenistein 8-OHG	Structural Classification Flavonoids Flavones Leguminosae Glycine max (L.) merr Source classification Plants	Reactive Oxygen Species (ROS) NO Synthase
8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O₂⁻). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein (HY-14596). The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.

Cat. No.	Product Name	Chemical Structure

HY-144577S

Ortho-hydroxy atorvastatin-d5 calcium
Ortho-hydroxy atorvastatin-d₅ calcium is the deuterium labeled Ortho-hydroxy atorvastatin (HY-144577) . Ortho-hydroxy atorvastatin is the metabolic of Atorvastatin (HY-B0589) .

HY-131496S

ortho-Topolin riboside-d4
ortho-Topolin riboside-d₄ is deuterium labeled ortho-Topolin riboside .

HY-136346S

Ortho-hydroxy atorvastatin lactone-d5
Ortho-hydroxy atorvastatin lactone-d₅ is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .

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ortho

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products