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Results for "

neurodevelopmental

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) AMPK (2) Apoptosis (2) CDK (2) E1/E2/E3 Enzyme (2) Fluorescent Dye (1) Histone Demethylase (2) iGluR (1) mGluR (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Protein Prenyltransferase (1) Sodium Channel (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Neurological Disease (14)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138830

TAK-418	Histone Demethylase	Neurological Disease
TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC₅₀ of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models .

HY-110325

PF-04885614	Sodium Channel	Neurological Disease
PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment .

HY-B1740

Pregnenolone acetate	Microtubule/Tubulin	Neurological Disease
Pregnenolone acetate (compound #43), a nonmetabolized Pregnenolone (HY-B0151) analog, can promote neurite extension and induce a change in growth cone morphology in primary cultures of cerebellar granule neurons. Pregnenolone acetate, a neurosteroid, increases microtubule polymerization. Pregnenolone acetate has the potential for neurodevelopmental diseases research .

HY-D0257

Tartrazine 1 Publications Verification Acid Yellow 23; FD&C Yellow No. 5	Fluorescent Dye Apoptosis Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease
Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .

HY-139580

Plazinemdor CAD-9303	iGluR	Neurological Disease
Plazinemdor is a N-methyl-D-aspartate(NMDA) receptor positive allosteric modulator. Plazinemdor can be uses in the research of psychiatric, neurological, and neurodevelopmental disorders, as well as diseases of the nervous system ..

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium	E1/E2/E3 Enzyme	Others
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-120229

GGTI-2147	Protein Prenyltransferase	Neurological Disease
GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia .

HY-106769A

(3aR,9aR)-Fluparoxan hydrochloride (3aR,9aR)-GR50360 hydrochloride	Others	Neurological Disease
(3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) hydrochloride is a compound that can be used to synthesize and prevent and improve neurodevelopmental disorders .

HY-172127

NUAK1-IN-1	AMPK CDK	Neurological Disease Cancer
NUAK1-IN-1 (Compound 9) is a NUAK1 (IC₅₀ of 5.012 nM) and CDK4 inhibitor. NUAK1-IN-1 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research .

HY-172128

NUAK1-IN-2	AMPK CDK	Neurological Disease Cancer
NUAK1-IN-2 (Compound 24) is a NUAK1 (IC₅₀ of 3.162 nM) and CDK2/4/6 inhibitor. NUAK1-IN-2 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research .

HY-P10430

Stalk peptide	Transmembrane Glycoprotein	Neurological Disease
Stalk peptide is a GPR110 activator. Stalk peptide is released from GPCR Autoproteolysis INducing domain by autocatalytic process and then Stalk peptide is inserted into the ligand-binding pocket of the receptor to activate the receptor. Stalk peptide can promote nerve growth and synaptic formation. Stalk peptide can be used to study neurodevelopmental and neurodegenerative diseases .

HY-148130

Rugonersen RG6091; RO7248824	E1/E2/E3 Enzyme	Others
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-110152

LSN2463359	mGluR	Neurological Disease
LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu₅). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model . LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-138830A

(S,S)-TAK-418	Histone Demethylase	Neurological Disease
(S,S)-TAK-418 is a potent inhibitor of lysine-specific demethylase 1 (LSD1), demonstrating significant normalization of aberrant gene expression in neurodevelopmental disorders. (S,S)-TAK-418 also ameliorates ASD-like behaviors in rodent models affected by maternal exposure to valproate or poly I:C. (S,S)-TAK-418 modulates gene expression differently across various models and ages, indicating its potential as a therapeutic agent for conditions like autism spectrum disorder and schizophrenia.

HY-106769B

(3aR,9aR)-Fluparoxan (3aR,9aR)-GR50360	Adrenergic Receptor	Neurological Disease
(3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) is a highly selective and potent α2B adrenaline receptor antagonist with the activity of preventing, improving or inhibiting neurodevelopmental disorders and neurodegenerative diseases. As an α2B receptor antagonist, (3aR,9aR)-Fluparoxan can promote the recovery of neurological function. The mechanism of action of (3aR,9aR)-Fluparoxan makes it have important application potential in neuroscience research .

HY-104044A

Pamiparib maleate BGB-290 maleate	Apoptosis	Neurological Disease
Pamiparib maleate (BGB-290 maleate) is a highly potent and selective PARP inhibitor with neurotoxicity-inducing activity. Pamiparib maleate can effectively penetrate the blood-brain barrier and cause cerebral hemorrhage, brain atrophy, and movement disorders in zebrafish embryos exposed. Pamiparib maleate exposure downregulates the activities of acetylcholinesterase (AChE) and adenosine triphosphatase (ATPase) and leads to upregulation of oxidative stress, which triggers apoptosis and interferes with the expression of neurodevelopment-related genes. The use of pamiparib maleate is also accompanied by downregulation of the Notch signaling pathway, while activation of the Notch signaling pathway can partially rescue neurodevelopmental toxicity. Therefore, pamiparib maleate provides a reference for evaluating its potential neurotoxicity during embryonic development .

Cat. No.	Product Name	Type

HY-D0257

Tartrazine 1 Publications Verification Acid Yellow 23; FD&C Yellow No. 5	Dyes
Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .

Cat. No.	Product Name	Target	Research Area

HY-P10430

Stalk peptide	Transmembrane Glycoprotein	Neurological Disease
Stalk peptide is a GPR110 activator. Stalk peptide is released from GPCR Autoproteolysis INducing domain by autocatalytic process and then Stalk peptide is inserted into the ligand-binding pocket of the receptor to activate the receptor. Stalk peptide can promote nerve growth and synaptic formation. Stalk peptide can be used to study neurodevelopmental and neurodegenerative diseases .

Cat. No.	Product Name		Classification

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

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