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myotonic dystrophy kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cdc42-binding kinase (3) ADC Linker (1) Antibody-Oligonucleotide Conjugates (AOCs) (2) Ser/Thr Kinase (1) Transferrin Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)
Oligonucleotides:	Antisense Oligonucleotides (3)

7

Inhibitors & Agonists

3

Recombinant Proteins

3

Oligonucleotides

Targets Recommended: Cdc42-binding kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

(R)-BDP9066	Cdc42-binding kinase	Cancer
(R)-BDP9066 is an isomer of BDP9066 and has lower activity compared to BDP9066. BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 is derived from patent WO2019034890A1 (E118) .

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx	Ser/Thr Kinase	Others
Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

BDP9066 2 Publications Verification	Cdc42-binding kinase	Cancer
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC₅₀ of 64 nM for MRCKβ in SCC12 cells, K_i values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

Basivarsen DYNE-101 oligomer	Antibody-Oligonucleotide Conjugates (AOCs)	Others
Basivarsen (DYNE-101 oligomer) is composed of an antisense oligonucleotides and a linker (HY-177454). It is designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

Basivarsen linker	ADC Linker	Others
Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab (HY-P990780 Zeleciment) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

BDP8900	Cdc42-binding kinase	Cancer
BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .

Delpacibart etedesiran Del-desiran; AOC 1001	Antibody-Oligonucleotide Conjugates (AOCs) Transferrin Receptor	Inflammation/Immunology
Delpacibart braxlosiran (Del-desiran), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated with a siRNA targeting DMPK (DM1 protein kinase) mRNA. Delpacibart braxlosiran is used for the study of myotonic dystrophy type 1 (DM1) .

Species:	Human (3)
Tag:	Tag Free (1) GST (2)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	MRCKG Protein, Human (sf9) CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCKG; KAPPA-200	Human	Sf9 insect cells
	MRCKG Protein, Human (sf9) is the recombinant human-derived MRCKG, expressed by Sf9 insect cells , with tag Free labeled tag. ,

	MRCKα Protein, Human (sf9, GST) CDC42BPA; Serine/threonine-protein kinase MRCK alpha; CDC42-binding protein kinase alpha; DMPK-like alpha; myotonic dystrophy kinase-related CDC42-binding kinase alpha; MRCK alpha; myotonic dystrophy protein kinase-like alpha	Human	Sf9 insect cells
	The MRCKα protein is a key serine/threonine protein kinase downstream of CDC42 that coordinates cytoskeletal dynamics and cell migration. MRCKα phosphorylates PPP1R12C and MYL9/MLC2, regulating actin reorganization. MRCKα Protein, Human (sf9, GST) is the recombinant human-derived MRCKα protein, expressed by sf9 insect cells , with N-GST labeled tag.

	MRCKβ Protein, Human (sf9, GST) CDC42BPB; CDC42 binding protein kinase beta (DMPK-like); MRCKB; KIAA1124; CDC42-binding protein kinase beta; myotonic dystrophy protein kinase-like beta; CDC42-binding protein kinase beta (DMPK-like); EC 2.7.11.1; DMPK-like beta; MRCK beta; myotonic dystrophy kinase-related CDC42-binding kinase beta; Serine/threonine-protein kinase MRCK beta	Human	Sf9 insect cells
	CDC42BPB protein is a key serine/threonine protein kinase downstream of CDC42 that controls cytoskeletal dynamics and cell migration. CDC42BPB phosphorylates PPP1R12C and MYL9/MLC2, regulates actin reorganization and shapes cell dynamics. MRCKβ Protein, Human (sf9, GST) is the recombinant human-derived MRCKβ, expressed by Sf9 insect cells, with GST labeled tag.

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Cat. No.	Product Name		Classification

Baliforsen ISIS 598769; IONIS 598769; BIIB 065; ISIS-DMPK-2.5Rx		Antisense Oligonucleotides
Baliforsen is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

Baliforsen sodium IONIS 598769 sodium; ISIS 598769 sodium		Antisense Oligonucleotides
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

Basivarsen DYNE-101 oligomer		Antisense Oligonucleotides
Basivarsen (DYNE-101 oligomer) is composed of an antisense oligonucleotides and a linker (HY-177454). It is designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

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