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Results for "

monovalent

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

13

Biochemical Assay Reagents

4

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2

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5

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7

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3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139813
    Phenanthriplatin

    		DNA Alkylator/Crosslinker Cancer
    Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .
    Phenanthriplatin
  • HY-W111581
    Copper(II) diethyldithiocarbamate
    1 Publications Verification

    Diethyldithiocarbamic acid copper salt

    		 Drug Derivative Cancer
    Copper(II) diethyldithiocarbamate has anticancer activity. Copper(II) diethyldithiocarbamate can be synthesized from monovalent copper-cysteamine and disulfiram .
    Copper(II) diethyldithiocarbamate
  • HY-108017
    Ferric maltol

    		Others Metabolic Disease Cancer
    Ferric maltol is an orally active monovalent iron (Fe 3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .
    Ferric maltol
  • HY-W025784
    Kalibor

    Sodium tetraphenylborate; Tetraphenylboron sodium

    		 Biochemical Assay Reagents Others
    Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
    Kalibor
  • HY-P99250
    Onartuzumab
    1 Publications Verification

    MetMAb

    		 c-Met/HGFR Cancer
    Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity .
    Onartuzumab
  • HY-P3711
    SPAI-1

    		Na+/K+ ATPase Others
    SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na +, K +-ATPase and H +, K +-ATPase in vitro, stimulates Mg 2+-ATPase .
    SPAI-1
  • HY-173351
    G-6599

    		Epigenetic Reader Domain Cancer
    G-6599 is a SMARCA2/A4 target-anchored monovalent degrader with DC50 values of 0.018 nM and 0.056 nM, respectively. G-6599 has degradation activity and anti-proliferative effects in AR-dependent prostate cancer cell lines .
    G-6599
  • HY-129525A
    Sulfo-SIAB sodium

    		ADC Linker Cancer
    Sulfo-SIAB sodium is a nonclaevable monovalent bilinker.
    Sulfo-SIAB sodium
  • HY-111525
    Monactin

    		Oxidative Phosphorylation Bacterial Antibiotic Infection
    Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .
    Monactin
  • HY-W025784R
    Kalibor (Standard)

    Sodium tetraphenylborate (Standard); Tetraphenylboron sodium (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    Kalibor (Standard) is the analytical standard of Kalibor. This product is intended for research and analytical applications. Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
    Kalibor (Standard)
  • HY-W1049091B
    mPEG-Alkyne (MW 10000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 10000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 10000)
  • HY-W1049091D
    mPEG-Alkyne (MW 40000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 40000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 40000)
  • HY-W1049091A
    mPEG-Alkyne (MW 5000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 5000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 5000)
  • HY-108017R
    Ferric maltol (Standard)

    		Others Metabolic Disease Cancer
    Ferric maltol (Standard) is the analytical standard of Ferric maltol. This product is intended for research and analytical applications. Ferric maltol is an orally active monovalent iron (Fe3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .
    Ferric maltol (Standard)
  • HY-W1049105
    mPEG-Alkyne (MW 2000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 2000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 2000)
  • HY-W1049091
    mPEG-Alkyne (MW 1000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 1000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 1000)
  • HY-W1049091C
    mPEG-Alkyne (MW 20000)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 20000) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 20000)
  • HY-W1049091E
    mPEG-Alkyne (MW 3400)

    		Biochemical Assay Reagents Others
    mPEG-Alkyne (MW 3400) is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG-Alkyne (MW 3400)
  • HY-A0068
    Aurothioglucose
    1 Publications Verification

    Gold thioglucose

    		 NF-κB HIV Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .
    Aurothioglucose
  • HY-163641
    AR Degrader-1

    		Molecular Glues Androgen Receptor E1/E2/E3 Enzyme Cancer
    AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells .
    AR Degrader-1
  • HY-163638
    BRD4 degrader-1

    		Molecular Glues Epigenetic Reader Domain E1/E2/E3 Enzyme Cancer
    BRD4 degrader-1 (Compound ML 1-50) is a monovalent and covalent molecular glue BRD4 degrader. BRD4 degrader-1 targets DCAF16 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .
    BRD4 degrader-1
  • HY-N4302
    Monensin

    Monensin A

    		 Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt Infection Cancer
    Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na +/H + exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
    Monensin
  • HY-P2324
    Gramicidin A
    1 Publications Verification

    		 Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic Infection Cancer
    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
    Gramicidin A
  • HY-P2324A
    Gramicidin A TFA

    		Antibiotic Bacterial Infection
    Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
    Gramicidin A TFA
  • HY-17409
    Nystatin
    Maximum Cited Publications
    40 Publications Verification

    		 Fungal Antibiotic Apoptosis Bacterial Infection Cancer
    Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .
    Nystatin
  • HY-N6790
    Nonactin

    Ammonium ionophore I

    		 Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP Infection Cancer
    Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K +, and NH4 +, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .
    Nonactin
  • HY-163639
    BRD4 degrader-2

    		Molecular Glues Epigenetic Reader Domain E1/E2/E3 Enzyme Cancer
    BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .
    BRD4 degrader-2
  • HY-P10228
    S-Thanatin

    		Fungal Bacterial Infection
    S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
    S-Thanatin
  • HY-172273B
    DSPE-PEG5000-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG5000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG5000-M2pep can be used for drug delivery .
    DSPE-PEG5000-Mal-Cys-YEQDPWGVKWWY
  • HY-172273A
    DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG2000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG2000-M2pep can be used for drug delivery .
    DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY
  • HY-172273
    DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG1000-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG1000-M2pep can be used for drug delivery .
    DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY
  • HY-172273C
    DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG3400-M2pep is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG3400-M2pep can be used for drug delivery .
    DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY
  • HY-P991518
    IBI-322

    		PD-1/PD-L1 CD47 Cancer
    IBI-322 is a bispecific antibody targeting PD-L1 and CD47. IBI-322 attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. IBI-322 selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro .
    IBI-322

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