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Results for "

monomethyl auristatin F

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Peptides

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-79256
    MMAF-OMe
    1 Publications Verification

    monomethyl auristatin F methyl ester

    		 ADC Payload Cancer
    MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 -) cell lines, respectively.
    MMAF-OMe
  • HY-128711
    MAL-di-EG-Val-Cit-PAB-MMAF

    		Drug-Linker Conjugates for ADC Cancer
    MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F) .
    MAL-di-EG-Val-Cit-PAB-MMAF
  • HY-W142140A
    N-Methyl-DL-valine hydrochloride

    N-Methylvaline hydrochloride

    		 Amino Acid Derivatives Cancer
    N-Methyl-DL-valine (N-Methylvaline) hydrochloride is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine hydrochloride involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
    N-Methyl-DL-valine hydrochloride
  • HY-15578
    McMMAF
    5+ Cited Publications

    Maleimidocaproyl monomethylauristatin F

    		 Drug-Linker Conjugates for ADC Apoptosis Cancer
    McMMAF (Maleimidocaproyl monomethylauristatin F) is an active molecule linker for ADC, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with the protecting group maleimidocaproyl. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
    McMMAF
  • HY-W142140
    N-Methyl-DL-valine

    N-Methylvaline

    		 Amino Acid Derivatives Others
    N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
    N-Methyl-DL-valine
  • HY-171544
    AGS-16C3F

    AGS-16M8F

    		 Antibody-Drug Conjugates (ADCs) Phosphodiesterase (PDE) Cancer
    AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC) .
    AGS-16C3F

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