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molecular level

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2243B
    Anhydrous sodium dihydrogen phosphate, for molecular biology
    1 Publications Verification

    Sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology

    		 Biochemical Assay Reagents Others
    Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
    Anhydrous sodium dihydrogen phosphate, for molecular biology
  • HY-W003371
    CGP 44 645

    		Drug Metabolite Others
    CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific .
    CGP 44 645
  • HY-170430
    HGC652

    		Molecular Glues E1/E2/E3 Enzyme Cancer
    HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21 .
    HGC652
  • HY-W181530
    NCT02

    		Molecular Glues CDK Apoptosis Ligands for E3 Ligase Cancer
    NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models .
    NCT02
  • HY-Y1309
    1-Naphthol

    Furro ER; NSC 9586; Nako TRB

    		 Endogenous Metabolite Others
    1-naphthol (Furro ER) is an excited state proton transfer (ESPT) fluorescent molecular probe. 1-naphthol can sense the hydrophobic domains in micellar aggregation and accurately sense the sol-gel transition. 1-naphthol can be used to study the thermally induced microenvironmental changes and hydration levels of Pluronic F127 (PF127) in different microenvironments in aqueous media .
    1-Naphthol
  • HY-B2243BR
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard)

    Sodium phosphate monobasic for molecular biology (Standard); Monosodium dihydrogen orthophosphate for molecular biology (Standard); Monosodium phosphate for molecular biology (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard) is the analytical standard of Anhydrous sodium dihydrogen phosphate, for molecular biology. This product is intended for research and analytical applications. Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard)
  • HY-161883
    JP-2-249

    		Molecular Glues Epigenetic Reader Domain Cancer
    JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM .
    JP-2-249
  • HY-D2514
    Cy3-PEG-DSPE (MW 1000)

    		Fluorescent Dye Others
    Cy3-PEG-DSPE (MW 1000) is a compound for the labeling and visualization of nanoparticles or other materials. Cy3-PEG-DSPE (MW 1000) has a variety of applications including drug delivery, cellular imaging, tracing of bioprocesses, and the study of interactions at the molecular level.
    Cy3-PEG-DSPE (MW 1000)
  • HY-D2518
    Cy3-PEG-DSPE (MW 10000)

    		Fluorescent Dye Others
    Cy3-PEG-DSPE (MW 10000) is a compound for the labeling and visualization of nanoparticles or other materials. Cy3-PEG-DSPE (MW 10000) has a variety of applications including drug delivery, cellular imaging, tracing of bioprocesses, and the study of interactions at the molecular level.
    Cy3-PEG-DSPE (MW 10000)
  • HY-W003371R
    CGP 44 645 (Standard)

    		Drug Metabolite Reference Standards Others
    CGP 44 645 (Standard) is the analytical standard of CGP 44 645. This product is intended for research and analytical applications. CGP 44 645 is the methanol metabolite of Letrozole (HY-14248) and is a molecular indicator for evaluating its metabolic kinetics in microsomes in vitro. Levels of CGP 44 645 in rat liver microsomes may be sex-specific .
    CGP 44 645 (Standard)
  • HY-176255
    TBK1 degrader-4

    		Molecular Glues Interleukin Related CCR Inflammation/Immunology
    TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD) .
    TBK1 degrader-4
  • HY-114395
    NVS-ZP7-4
    5+ Cited Publications

    		 Ferroptosis SLC39 (Zinc Transporter) Inflammation/Immunology
    NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death .
    NVS-ZP7-4
  • HY-158439
    anti-TNBC agent-7

    		JAK STAT Cancer
    anti-TNBC agent-7 (Compound 13c) possesses anticancer activity, serving as a molecular probe to recognize and regulate the signal transduction of the USP21/JAK2/STAT3 axis, exhibiting nanomolar-level cytotoxicity against MDA-MB-231 and HCC-1806 cancer cells, effectively combating triple-negative breast cancer (TNBC) .
    anti-TNBC agent-7
  • HY-115461
    MID-1

    		Insulin Receptor Metabolic Disease
    MID-1 is a disruptor of MG53-IRS-1 (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake .
    MID-1
  • HY-153916
    TCRS-417

    T417

    		 HOXA DNA/RNA Synthesis NEKs Neurological Disease Inflammation/Immunology Cancer
    TCRS-417 (T417) is a small-molecular inhibitor for PBX1. TCRS-417 can directly block PBX1-binding to DNA (IC50 = 6.58 μM), and affects PBX1 transcription. TCRS-417 is able to hammer out the stemness traits of Carboplatin (HY-17393)-resistant (CR) cells to revert to a differentiated status through tacking PBX1 signaling cascade. TCRS-417 significantly suppresses self-renewal and proliferation of cancer cells expressing high levels of PBX1. TCRS-417 can decrease the mRNA levels of FOXM1, NEK2, and E2F2 in cancer cell lines. TCRS-417 is selectively toxic against chr1q-amp myeloma and solid tumor cells .
    TCRS-417
  • HY-137294
    BTPTT-4F

    Y6

    		 Endogenous Metabolite Others
    BTPTT-4F (Y6) is a non-fullerene acceptor-donor-acceptor (A-D-A) type small molecular acceptor (SMA) characterized by its flexible alkyl chains and centrally fused ring structure. Featuring a ladder-type electron-deficient core, BTPTT-4F can be effectively blended with PM6, showcasing significant potential for enhancing the performance of organic photovoltaic applications. Its tailored optical properties and adjustable electronic energy levels contribute to improved thermal and photochemical stability, making it a promising candidate for next-generation high-performance organic solar cells.
    BTPTT-4F
  • HY-172533
    3′,5′-DiOA-dC

    		STING Cancer
    3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG). 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model .
    3′,5′-DiOA-dC
  • HY-149127
    Rosolutamide

    ASC-JM17; ALZ-003

    		 Keap1-Nrf2 Androgen Receptor HSP Mitophagy Metabolic Disease
    Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels .
    Rosolutamide
  • HY-D1056E
    Lipopolysaccharides, from P. aeruginosa 10

    LPS, from Pseudomonas aeruginosa (10)

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are lipopolysaccharide endotoxins and TLR4 activators derived from Pseudomonas aeruginosa 10, and are classified as S-type LPS. Lipopolysaccharides from P. aeruginosa 10 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. The lipopolysaccharides of P. aeruginosa 10 have a fatty acid composition distinct from common enterobacteria, an exceptionally high degree of phosphorylation (triphosphate residues have been detected), and a unique outer region of the core oligosaccharide. Additionally, their O-specific side chains are typically rich in novel aminosugars. Lipopolysaccharides from P. aeruginosa 10 demonstrate susceptibility to viruses, with the level of susceptibility determined by the content of high molecular weight polysaccharides in their composition. The absence of high molecular weight polysaccharides increases their sensitivity to bacteriophages .
    It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.
    Lipopolysaccharides, from P. aeruginosa 10
  • HY-W127461
    Ganglioside GM2, Asialo

    Gangliotriosylceramide

    		 Biochemical Assay Reagents Others
    Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.
    Ganglioside GM2, Asialo
  • HY-169056
    SLC7A11-IN-2

    		Reactive Oxygen Species (ROS) Cancer
    SLC7A11-IN-2 (Compound 1) is an SLC7A11/xCT inhibitor. SLC7A11-IN-2 induces cell death in HeLa cells by lowering intracellular glutathione levels and increasing oxidative stress, thereby disrupting the oxidative balance within the cells, with an IC50 value of 10.23 μM. Molecular dynamics simulation analysis indicates that SLC7A11-IN-2 has a stronger binding affinity to SLC7A11 compared to Erastin (HY-15763). SLC7A11-IN-2 can be utilized in research within the field of cervical cancer .
    SLC7A11-IN-2
  • HY-145858
    Chalcones A-N-5

    		Ferroptosis Cancer
    Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD .
    Chalcones A-N-5
  • HY-126969
    C333H

    		PPAR Metabolic Disease
    C333H is a selective PPARγ modulator with insulin-sensitizing and hypoglycemic activities. C333H exhibits similar insulin-sensitizing effects to thiazolidinediones (TZDs) in diabetic mouse models without significantly increasing body weight or adipose tissue weight. C333H increases circulating high molecular weight adiponectin isoform levels in diabetic db/db mice, reduces serine phosphorylation of PPARγ 273 in brown adipose tissue, and selectively modulates the expression of specific PPARγ target genes in adipose tissue. Express. C333H exhibits weak recruitment of co-activators and weak dissociation of co-repressors in vitro. These properties suggest that C333H may be a potential inhibitor of type 2 diabetes .
    C333H
  • HY-D1056C1
    Lipopolysaccharides, from S. enterica serotype enteritidis

    LPS, from Salmonella enterica (Serotype enteritidis)

    		 Toll-like Receptor (TLR) Inflammation/Immunology
    Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma .
    It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.
    Lipopolysaccharides, from S. enterica serotype enteritidis

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