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mitochondrial electron transport

" in MedChemExpress (MCE) Product Catalog:

36

Inhibitors & Agonists

4

Biochemical Assay Reagents

7

Natural
Products

4

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114197
    Antimalarial agent 14

    		Mitochondrial Metabolism Parasite Infection
    Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent .
    Antimalarial agent 14
  • HY-130055
    HQNO
    1 Publications Verification

    		 Mitochondrial Metabolism Infection
    HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .
    HQNO
  • HY-112177
    Myxothiazol

    		Fungal Mitochondrial Metabolism Antibiotic Infection
    Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .
    Myxothiazol
  • HY-126222A
    MitoTam iodide, hydriodide

    		Apoptosis Mitochondrial Metabolism Cancer
    MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .
    MitoTam iodide, hydriodide
  • HY-126222B
    (E/Z)-MitoTam iodide, hydriodide

    MitoTax iodide, hydriodide

    		 Mitochondrial Metabolism Apoptosis Cancer
    (E/Z)-MitoTam (iodide, hydriodide) (MitoTam (iodide, hydriodide)) is the E/Z mixture of MitoTam iodide, hydriodide. MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .
    (E/Z)-MitoTam iodide, hydriodide
  • HY-B1756
    Rotenone
    Maximum Cited Publications
    137 Publications Verification

    		 Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone
  • HY-136406
    Bongkrekic acid

    		ATP Synthase Infection Cancer
    Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans . Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
    Bongkrekic acid
  • HY-125857C
    Cytochrome C (bovine heart)

    		Biochemical Assay Reagents Apoptosis Metabolic Disease
    Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier .
    Cytochrome C (bovine heart)
  • HY-130055R
    HQNO (Standard)

    		Reference Standards Mitochondrial Metabolism Infection
    HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
    HQNO (Standard)
  • HY-126222
    MitoTam bromide, hydrobromide

    		Apoptosis Mitochondrial Metabolism Cancer
    MitoTam bromide, hydrobromide, a Tamoxifen derivative , is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells .
    MitoTam bromide, hydrobromide
  • HY-125857B
    Cytochrome C (Saccharomyces cerevisiae)

    		Biochemical Assay Reagents Apoptosis Metabolic Disease
    Cytochrome C (Saccharomyces cerevisiae) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (Saccharomyces cerevisiae) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (Saccharomyces cerevisiae) can act as a single electron carrier .
    Cytochrome C (Saccharomyces cerevisiae)
  • HY-125857A
    Cytochrome C (equine heart)

    		Biochemical Assay Reagents Apoptosis Metabolic Disease
    Cytochrome C (equine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (equine heart) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (equine heart) can act as a single electron carrier .
    Cytochrome C (equine heart)
  • HY-120338
    RYL-552

    		Mitochondrial Metabolism Parasite Infection
    RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor .
    RYL-552
  • HY-121214
    Amisulbrom

    		Fungal Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS) Infection Cardiovascular Disease
    Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom
  • HY-B1756R
    Rotenone (Standard)

    		Reference Standards Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone (Standard)
  • HY-136406S
    Bongkrekic acid-13C28
    1 Publications Verification

    		 Isotope-Labeled Compounds ATP Synthase Cancer
    Bongkrekic acid- 13C28 is the 13C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
    Bongkrekic acid-13C28
  • HY-125857
    Cytochrome C

    		Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Metabolic Disease
    Cytochrome C is a multi-functional enzyme involving in life and death decisions of the cell. Cytochrome C is essential in mitochondrial electron transport and intrinsic type II apoptosis .
    Cytochrome C
  • HY-B1756S
    Rotenone-d3

    		Isotope-Labeled Compounds Apoptosis Mitochondrial Metabolism Autophagy Neurological Disease Cancer
    Rotenone-d3 is the deuterium labeled Rotenone (HY-B1756). Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone-d3
  • HY-162515
    8-OAc

    		Mitochondrial Metabolism Cancer
    8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines .
    8-OAc
  • HY-119687
    Bifenazate

    		GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide Infection Cardiovascular Disease
    Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate
  • HY-13834
    GW844520

    		Parasite Cytochrome P450 Infection
    GW844520 is an orally active inhibitor of cytochrome bc1 complex. GW844520 can be used in malaria and anti-plasmodium related research .
    GW844520
  • HY-B0817
    Pyridaben
    1 Publications Verification

    		 Parasite Infection
    Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
    Pyridaben
  • HY-170369
    SHO1122147

    		Mitochondrial Metabolism Metabolic Disease
    SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC50=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .
    SHO1122147
  • HY-155849
    PKM2-IN-4

    		Pyruvate Kinase Cancer
    Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling .
    PKM2-IN-4
  • HY-121248
    Hydramethylnon

    AC217300

    		 Mitochondrial Metabolism Infection
    Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects .
    Hydramethylnon
  • HY-W725476
    Bifenazate-d5

    		Reactive Oxygen Species (ROS) Infection
    Bifenazate-d5 is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate-d5
  • HY-119687R
    Bifenazate (Standard)

    		Reference Standards GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide Infection Cardiovascular Disease
    Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate (Standard)
  • HY-B0817S
    Pyridaben-d13

    		Parasite Infection
    Pyridaben-d13 is the deuterium labeled Pyridaben . Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
    Pyridaben-d13
  • HY-125283
    IM176OUT05

    2-Me-Phen hydrochloride; 2-Me-Phenformin hydrochloride

    		 Mitochondrial Metabolism Oxidative Phosphorylation Metabolic Disease
    IM176OUT05 (2-Me-Phen hydrochloride), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process .
    IM176OUT05
  • HY-B0817R
    Pyridaben (Standard)

    		Reference Standards Parasite Infection
    Pyridaben (Standard) is the analytical standard of Pyridaben. This product is intended for research and analytical applications. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .
    Pyridaben (Standard)
  • HY-114936
    Piericidin A
    4 Publications Verification

    AR-054

    		 Bacterial ADC Payload Antibiotic Mitochondrial Metabolism Infection Neurological Disease Cancer
    Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .
    Piericidin A
  • HY-125283A
    IM176OUT05 free base

    2-Me-Phen; 2-Me-Phenformin

    		 Oxidative Phosphorylation Mitochondrial Metabolism Metabolic Disease
    IM176OUT05 free base (2-Me-Phen), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 free base inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 free base activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process .
    IM176OUT05 free base
  • HY-178033
    Antileishmanial agent-35

    		Parasite Mitochondrial Metabolism Reactive Oxygen Species (ROS) Infection
    Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC50 of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research .
    Antileishmanial agent-35
  • HY-N12887
    Mycothiazole

    		Mitochondrial Metabolism Others Cancer
    Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .
    Mycothiazole
  • HY-176253
    Antitrypanosomal agent 26

    		Parasite Infection
    Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .
    Antitrypanosomal agent 26
  • HY-17516R
    Tolfenpyrad (Standard)

    		Reference Standards Insecticide Bacterial Mitochondrial Metabolism Infection
    Tolfenpyrad (Standard) is the analytical standard of Tolfenpyrad (HY-17516). This product is intended for research and analytical applications. Tolfenpyrad is an orally active insecticide, acaricide and antibacterial agent. Tolfenpyrad inhibits Complex I in the mitochondrial respiratory electron transport chain, interfering with the cell respiration process. Tolfenpyrad has significant insecticidal activity against a variety of insect pests such as H. contortus, Coccinella septempunctata. Tolfenpyrad has antibacterial activity against Francisella novicida, with an IC50 of 1.2 µM or 1.5 µM .
    Tolfenpyrad (Standard)

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