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Results for "

mitochondrial Electron Transport Chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitochondrial Metabolism (21) Antibiotic (1) Apoptosis (6) ATP Synthase (2) Autophagy (3) Bacterial (1) ClpP (1) Fungal (1) GABA Receptor (2) Insecticide (3) Isotope-Labeled Compounds (2) Na+/K+ ATPase (2) Oxidative Phosphorylation (2) Parasite (3) Reactive Oxygen Species (ROS) (4) Reference Standards (4)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Infection (12) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Mitochondrial Metabolism FATP Mitophagy ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130055

HQNO 1 Publications Verification	Mitochondrial Metabolism	Infection
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-112177

Myxothiazol	Fungal Mitochondrial Metabolism Antibiotic	Infection
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-126222A

MitoTam iodide, hydriodide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .

HY-126222B

(E/Z)-MitoTam iodide, hydriodide MitoTax iodide, hydriodide	Mitochondrial Metabolism Apoptosis	Cancer
(E/Z)-MitoTam (iodide, hydriodide) (MitoTam (iodide, hydriodide)) is the E/Z mixture of MitoTam iodide, hydriodide. MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .

HY-B1756

Rotenone Maximum Cited Publications 144 Publications Verification	Mitochondrial Metabolism Autophagy Apoptosis	Neurological Disease Cancer
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-120338

RYL-552	Mitochondrial Metabolism Parasite	Infection
RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a *P. falciparum NADH dehydrogenase 2 (PfNDH2)* inhibtor .

HY-136406

Bongkrekic acid	ATP Synthase	Infection Cancer
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans . Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-130055R

HQNO (Standard)	Reference Standards Mitochondrial Metabolism	Infection
HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

HY-126222

MitoTam bromide, hydrobromide	Apoptosis Mitochondrial Metabolism	Cancer
MitoTam bromide, hydrobromide, a Tamoxifen derivative , is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells .

HY-178749

MS6076	ClpP Mitochondrial Metabolism	Cancer
MS6076 is a mitochondrial protease ClpP agonist. MS6076 specifically activates the ClpP protease in the mitochondrial matrix, significantly disrupting mitochondrial Electron Transport Chain (ETC) function by accelerating the degradation of unfolded proteins. MS6076 exhibits potent cytotoxicity against a variety of breast cancer cell lines, including triple-negative breast cancer cells (MDA-MB-468, MDA-MB-231) and other subtypes (SK-BR-3, MCF-7, BT-474). MS6076 can be used for the study of breast cancer .

HY-B1756R

Rotenone (Standard)	Reference Standards Mitochondrial Metabolism Autophagy Apoptosis	Neurological Disease Cancer
Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-B1756S

Rotenone-d3	Isotope-Labeled Compounds Apoptosis Mitochondrial Metabolism Autophagy	Neurological Disease Cancer
Rotenone-d₃ is the deuterium labeled Rotenone (HY-B1756). Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-162515

8-OAc	Mitochondrial Metabolism	Cancer
8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines .

HY-136406S

Bongkrekic acid-13C28 1 Publications Verification	Isotope-Labeled Compounds ATP Synthase	Cancer
Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-119687

Bifenazate	GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide	Infection Cardiovascular Disease
Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-121248

Hydramethylnon AC217300	Mitochondrial Metabolism	Infection
Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects .

HY-170369

SHO1122147	Mitochondrial Metabolism	Metabolic Disease
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC₅₀=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .

HY-W725476

Bifenazate-d5	Reactive Oxygen Species (ROS)	Infection
Bifenazate-d₅ is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-119687R

Bifenazate (Standard)	Reference Standards GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide	Infection Cardiovascular Disease
Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

HY-125283

IM176OUT05 2-Me-Phen hydrochloride; 2-Me-Phenformin hydrochloride	Mitochondrial Metabolism Oxidative Phosphorylation	Metabolic Disease
IM176OUT05 (2-Me-Phen hydrochloride), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2 μM. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process .

HY-125283A

IM176OUT05 free base 2-Me-Phen; 2-Me-Phenformin	Oxidative Phosphorylation Mitochondrial Metabolism	Metabolic Disease
IM176OUT05 free base (2-Me-Phen), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 free base inhibits mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2 μM. IM176OUT05 free base activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process .

HY-178033

Antileishmanial agent-35	Parasite Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection
Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC₅₀ of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research .

HY-N12887

Mycothiazole	Mitochondrial Metabolism	Others Cancer
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-176253

Antitrypanosomal agent 26	Parasite	Infection
Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC₅₀ value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .

HY-17516R

Tolfenpyrad (Standard)	Reference Standards Insecticide Bacterial Mitochondrial Metabolism	Infection
Tolfenpyrad (Standard) is the analytical standard of Tolfenpyrad (HY-17516). This product is intended for research and analytical applications. Tolfenpyrad is an orally active insecticide, acaricide and antibacterial agent. Tolfenpyrad inhibits Complex I in the mitochondrial respiratory electron transport chain, interfering with the cell respiration process. Tolfenpyrad has significant insecticidal activity against a variety of insect pests such as H. contortus, Coccinella septempunctata. Tolfenpyrad has antibacterial activity against Francisella novicida, with an IC₅₀ of 1.2 µM or 1.5 µM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-130055

HQNO 1 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Mitochondrial Metabolism
HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a K_d of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .

HY-112177

Myxothiazol	Infection Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Disease Research Disease Research Fields Other Antibiotics	Fungal Mitochondrial Metabolism Antibiotic
Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .

HY-B1756

Rotenone 140+ Cited Publications	Flavonoids Neurological Disease Classification of Application Fields Leguminosae Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Mitochondrial Metabolism Autophagy Apoptosis
Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-B1756R

Rotenone (Standard)	Flavonoids Leguminosae Derris trifoliata Lour. Plants	Reference Standards Mitochondrial Metabolism Autophagy Apoptosis
Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-130055R

HQNO (Standard)	Natural Products Microorganisms Source classification	Reference Standards Mitochondrial Metabolism
HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].

HY-N12887

Mycothiazole	Natural Products Marine natural products Source classification Sponge	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

Cat. No.	Product Name	Chemical Structure

HY-136406S

Bongkrekic acid-13C28 1 Publications Verification
Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

Bongkrekic acid-13C28

1 Publications Verification

Bongkrekic acid- ¹³C₂₈ is the ¹³C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .

HY-B1756S

Rotenone-d3
Rotenone-d₃ is the deuterium labeled Rotenone (HY-B1756). Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-W725476

Bifenazate-d5
Bifenazate-d₅ is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .

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