2. Search Result
Search Result
Results for "

lysosomal acidification

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

4

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108462
    ML-SA1
    3 Publications Verification

    		 Dengue Virus TRP Channel Flavivirus Infection
    ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral .
    ML-SA1
  • HY-N1724
    Concanamycin A
    Maximum Cited Publications
    13 Publications Verification

    Antibiotic X 4357B; Folimycin; X 4357B

    		 Proton Pump Bacterial Antibiotic Infection Inflammation/Immunology Cancer
    Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
    Concanamycin A
  • HY-128892
    EN6
    3 Publications Verification

    		 Autophagy Neurological Disease
    EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .
    EN6
  • HY-N14423
    Concanamycin D

    		Proton Pump Inflammation/Immunology
    Concanamycin D is a lysosomal acidification inhibitor with an IC50 value of 0.085 nM .
    Concanamycin D
  • HY-N14425
    Concanamycin E

    		Proton Pump Inflammation/Immunology
    Concanamycin E is a lysosomal acidification inhibitor with an IC50 value of 0.038 nM .
    Concanamycin E
  • HY-N8530
    Conodurine

    		Others Inflammation/Immunology
    Conodurine is a monoterpenoid indole alkaloid. Conodurine can inhibit lysosomal acidification. Conodurineis isolated from the natural Tabernaemontana corymbosa .
    Conodurine
  • HY-169210
    ECDD-S18

    		Apoptosis Cancer
    ECDD-S18 (compund ECDD-S18) induces apoptosis in a dose-dependent manner, effectively targets vacuolar ATPase (V-ATPase), and impairs lysosomal acidification .
    ECDD-S18
  • HY-168122
    Apoptosis inducer 29

    		Apoptosis Cancer
    Apoptosis inducer 29 (compund Y9) is an apoptosis inducer that exhibits antitumor effects in non-small cell lung cancer. Apoptosis inducer 29 selectively acidifies lysosomes and induces lysosomal dysfunction, with superior potency to Gboixn (HY-111651) in vitro and in vivo. .
    Apoptosis inducer 29

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: