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linker-payload platform

" in MedChemExpress (MCE) Product Catalog:

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163099
    P5(PEG24)-VC-PAB-Exatecan

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    P5(PEG24)-VC-PAB-Exatecan (LP5) is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor Exatecan (HY-13631) and a linker P5(PEG24)-VC-PAB to make antibody agent conjugate (ADC). P5(PEG24)-VC-PAB-Exatecan can be used for the research of tumor .
    P5(PEG24)-VC-PAB-Exatecan
  • HY-177542
    Emiltatug ledadotin

    Emi-Le; XMT-1660

    		 Antibody-Drug Conjugates (ADCs) Cancer
    Emiltatug ledadotin (Emi-Le; XMT-1660) is a B7-H4-targeted antibody-drug conjugate (ADC). Emiltatug ledadotin consists of a tumor-specific anti-B7-H4 monoclonal antibody Emiltatug (HY-P990918), a linker-payload system built on the novel Dolasynthen (DS) ADC platform (HY-177541), and achieves site-specific conjugation via GlycoConnect click chemistry. Emiltatug ledadotin inhibits the growth of B7-H4-positive cancer cells. Emiltatug ledadotin can be used for the study of B7-H4-overexpressing advanced solid tumors, particularly breast, ovarian, and endometrial cancers .
    Emiltatug ledadotin

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