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Results for "

leishmanial

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

2

Peptides

8

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131300
    Colchicoside

    		Parasite Infection
    Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .
    Colchicoside
  • HY-N6015
    Bacopasaponin C

    		Parasite Cancer
    Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities .
    Bacopasaponin C
  • HY-127160
    Benzoxonium chloride

    		Parasite Bacterial Infection
    Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
    Benzoxonium chloride
  • HY-101011
    Naloxonazine dihydrochloride

    		Opioid Receptor Infection Neurological Disease
    Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .
    Naloxonazine dihydrochloride
  • HY-B0483
    Tioxolone

    		Carbonic Anhydrase Parasite Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis .
    Tioxolone
  • HY-W159102
    8CN

    		Parasite Infection
    8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .
    8CN
  • HY-133838
    Ilmofosine

    BM41440

    		 Parasite PKC Infection Cancer
    Ilmofosine (BM41440) is a potent and selective protein kinase C inhibitor. Ilmofosine induces cell cycle arrest at the G2 phase. Ilmofosine also is an anti-leishmanial agent .
    Ilmofosine
  • HY-156464
    Topoisomerase I inhibitor 10

    		Topoisomerase Infection
    Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 27.91 μM .
    Topoisomerase I inhibitor 10
  • HY-127160R
    Benzoxonium chloride (Standard)

    		Parasite Bacterial Reference Standards Infection
    Benzoxonium (chloride) (Standard) is the analytical standard of Benzoxonium (chloride). This product is intended for research and analytical applications. Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
    Benzoxonium chloride (Standard)
  • HY-139666R
    N-Palmitoyl-L-glutamine (Standard)

    		Amino Acid Derivatives Reference Standards Others
    Benzoxonium (chloride) (Standard) is the analytical standard of Benzoxonium (chloride). This product is intended for research and analytical applications. Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .
    N-Palmitoyl-L-glutamine (Standard)
  • HY-N6015R
    Bacopasaponin C (Standard)

    		Reference Standards Parasite Cancer
    Bacopasaponin C (Standard) is the analytical standard of Bacopasaponin C. This product is intended for research and analytical applications. Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities .
    Bacopasaponin C (Standard)
  • HY-156462
    Topoisomerase I inhibitor 9

    		Topoisomerase Infection
    Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM .
    Topoisomerase I inhibitor 9
  • HY-13685
    Miltefosine
    Maximum Cited Publications
    12 Publications Verification

    HePC; Hexadecyl phosphocholine

    		 Akt HIV Parasite Infection Cancer
    Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
    Miltefosine
  • HY-P2310
    Defensin HNP-1 human

    		Bacterial Parasite Infection Cardiovascular Disease
    Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities .
    Defensin HNP-1 human
  • HY-B0483R
    Tioxolone (Standard)

    		Reference Standards Carbonic Anhydrase Parasite Autophagy Apoptosis Infection Inflammation/Immunology Cancer
    Tioxolone (Standard) is the analytical standard of Tioxolone. This product is intended for research and analytical applications. Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis .
    Tioxolone (Standard)
  • HY-P2310A
    Defensin HNP-1 human TFA

    		Bacterial Parasite Infection Cardiovascular Disease
    Defensin HNP-1 human TFA is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human TFA exhibits broad antimicrobial and anti-leishmanial activities .
    Defensin HNP-1 human TFA
  • HY-N7906
    Myricetin 3-O-glucoside

    Myricetin 3-β-D-glucopyranoside

    		 Bacterial Parasite Antibiotic Infection Inflammation/Immunology
    Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica and Hakmeitau beans. Myricetin 3-O-glucoside exhibits anti-Leishmanial, anti-inflammatory and antimicrobial activities .
    Myricetin 3-O-glucoside
  • HY-147857
    Antileishmanial agent-12

    		Parasite Infection
    Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 14.9, 21.3 and 9.3 μM, respectively .
    Antileishmanial agent-12
  • HY-147856
    Antileishmanial agent-11

    		Parasite Infection
    Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC50 values of 28.3, 24.8 and 13.0 μM, respectively .
    Antileishmanial agent-11
  • HY-13685R
    Miltefosine (Standard)

    		Akt HIV Parasite Infection Cancer
    Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
    Miltefosine (Standard)
  • HY-13685S1
    Miltefosine-d4

    HePC-d4; Hexadecyl phosphocholine-d4

    		 Isotope-Labeled Compounds Akt Parasite HIV Infection Cancer
    Miltefosine-d4 (HePC-d4) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .
    Miltefosine-d4
  • HY-W015818
    2-Benzoxazolinone
    1 Publications Verification

    2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole

    		 Parasite Infection
    2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent .
    2-Benzoxazolinone
  • HY-76228
    1H-pyrazole

    Pyrazole

    		 Drug Intermediate Biochemical Assay Reagents Infection Inflammation/Immunology
    1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
    1H-pyrazole
  • HY-129819
    (Rac)-DNDI-8219

    		Bacterial Infection
    (Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .
    (Rac)-DNDI-8219
  • HY-B0219A
    Allopurinol sodium
    5+ Cited Publications

    		 Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol sodium
  • HY-B0219
    Allopurinol
    5+ Cited Publications

    		 Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol
  • HY-B0219R
    Allopurinol (Standard)

    		Reference Standards Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol (Standard) is the analytical standard of Allopurinol. This product is intended for research and analytical applications. Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol (Standard)
  • HY-155845
    Antileishmanial agent-21

    		Parasite Infection
    Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM .
    Antileishmanial agent-21
  • HY-W015818R
    2-Benzoxazolinone (Standard)

    2-Benzoxazolone (Standard); 1,3-Benzoxazol-2(3H)-one (Standard); 2-Hydroxybenzoxazole (Standard)

    		 Reference Standards Parasite Infection
    2-Benzoxazolinone (Standard) is the analytical standard of 2-Benzoxazolinone. This product is intended for research and analytical applications. 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent[4].
    2-Benzoxazolinone (Standard)
  • HY-76228R
    1H-pyrazole (Standard)

    		Drug Intermediate Biochemical Assay Reagents Infection Inflammation/Immunology
    1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
    1H-pyrazole (Standard)
  • HY-B0219S1
    Allopurinol-13C,15N2

    		Isotope-Labeled Compounds Xanthine Oxidase Infection Neurological Disease Inflammation/Immunology Cancer
    Allopurinol- 13C, 15N2 is the 13C- and 15N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
    Allopurinol-13C,15N2
  • HY-W779244
    1H-Pyrazole-3,4,5-d3

    		Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate Infection
    1H-Pyrazole-3,4,5-d3 is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .
    1H-Pyrazole-3,4,5-d3
  • HY-155846
    Antileishmanial agent-22

    		Parasite Bacterial Infection
    Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .
    Antileishmanial agent-22

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