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Results for "

ischaemic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (7) Antibiotic (4) Apoptosis (10) ATP Synthase (1) Calcium Channel (3) Cholinesterase (ChE) (2) Collagen (1) Deubiquitinase (1) E1/E2/E3 Enzyme (1) HCN Channel (4) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Mitochondrial Metabolism (2) Nucleoside Antimetabolite/Analog (1) Parasite (1) PARP (2) PGE synthase (2) Phosphodiesterase (PDE) (2) Potassium Channel (2) Prostaglandin Receptor (1) Reference Standards (5) Ser/Thr Protease (1) Sodium Channel (2) TNF Receptor (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (26) Endocrinology (9) Infection (11) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (10)

By Targets:

Adrenergic Receptor (7)

Antibiotic (4)

Apoptosis (10)

ATP Synthase (1)

Calcium Channel (3)

Cholinesterase (ChE) (2)

Collagen (1)

Deubiquitinase (1)

E1/E2/E3 Enzyme (1)

HCN Channel (4)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (2)

Nucleoside Antimetabolite/Analog (1)

Parasite (1)

PARP (2)

PGE synthase (2)

Phosphodiesterase (PDE) (2)

Potassium Channel (2)

Prostaglandin Receptor (1)

Reference Standards (5)

Ser/Thr Protease (1)

Sodium Channel (2)

TNF Receptor (1)

By Research Areas:

Cancer (13)

Cardiovascular Disease (26)

Endocrinology (9)

Infection (11)

Inflammation/Immunology (4)

Metabolic Disease (5)

Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15877

BTB06584 2 Publications Verification	ATP Synthase	Cancer
BTB06584 is a selective and IF1-dependent mitochondrial F₁F_o-ATPase inhibitor without compromising ATP synthesis. BTB06584 can delays ischaemic cell death .

HY-132280

Tirilazad U 74006F free base	Antibiotic	Infection Neurological Disease
Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research .

HY-B0683

Limaprost 1 Publications Verification 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206	PGE synthase	Cardiovascular Disease Inflammation/Immunology
Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-116218C

Amelparib hydrochloride JPI-289 hydrochloride	PARP	Cardiovascular Disease Neurological Disease
Amelparib (JPI-289) hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib hydrochloride inhibits PARP-1 activity (IC₅₀ = 18.5 nM) and cellular PAR formation (IC₅₀ = 10.7 nM). Amelparib hydrochloride is a potential neuroprotective agent. Amelparib hydrochloride has the potential for the research of acute ischaemic stroke .

HY-116218

Amelparib JPI-289 free base	PARP	Cardiovascular Disease Neurological Disease
Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC₅₀=18.5 nM) and cellular PAR formation (IC₅₀=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke .

HY-106914

Sinitrodil ITF 296	Others	Cardiovascular Disease
Sinitrodil (ITF 296) is an orally active organic nitrate with *anti-ischaemic* effect. Sinitrodil can be used for acute and chronic heart diseases research .

HY-122070

Tirilazad mesylate U 74006F	Antibiotic	Infection Neurological Disease
Tirilazad mesylate (U 74006F) is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research .

HY-10679A

PF-03049423	Phosphodiesterase (PDE)	Neurological Disease
PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC₅₀ of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke .

HY-122070A

Tirilazad mesylate hydrate U 74006F hydrate	Antibiotic	Infection Metabolic Disease
Tirilazad mesylate hydrate is the hydrate form of Tirilazad mesylate (HY-122070). Tirilazad mesylate is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad mesylate can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad mesylate has antiviral activities against nCoV. Tirilazad mesylate is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research .

HY-10679

PF-03049423 free base	Phosphodiesterase (PDE)	Neurological Disease
PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC₅₀ of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke .

HY-116090

Conoidin A 1 Publications Verification	Parasite	Infection Cardiovascular Disease Neurological Disease
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC₅₀ of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) . Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease .

HY-108981

CERM11956	Calcium Channel	Cardiovascular Disease
CERM11956 is a potent anti-ischaemic agent. CERM11956 is a derivative of bepridil(HY-16952) .

HY-B1448A

Benidipine KW-3049 free base	Apoptosis Calcium Channel	Cardiovascular Disease
Benidipine is a potent and orally active calcium channel antagonist . Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells . Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats .

HY-W027553

Ipidacrine NIK-247 free base	Cholinesterase (ChE) Potassium Channel Sodium Channel	Neurological Disease Metabolic Disease
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-B0162

Ivabradine	HCN Channel	Cardiovascular Disease Cancer
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162A

Ivabradine hydrochloride 2 Publications Verification	HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-108845

Tenecteplase TNK-tPA	Ser/Thr Protease	Cardiovascular Disease
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke .

HY-B1448AS

(Rac)-Benidipine-d7	Apoptosis Calcium Channel	Cardiovascular Disease
(Rac)-Benidipine-d₇ is the deuterium labeled Benidipine . Benidipine is a potent and orally active calcium channel antagonist . Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells . Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats .

HY-B0162S

Ivabradine-d6	HCN Channel	Cardiovascular Disease
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162AR

Ivabradine hydrochloride (Standard)	Reference Standards HCN Channel	Cardiovascular Disease Endocrinology Cancer
Ivabradine (hydrochloride) (Standard) is the analytical standard of Ivabradine (hydrochloride). This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B1836R

Meldonium (Standard)	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Meldonium (Standard) is the analytical standard of Meldonium. This product is intended for research and analytical applications. Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor .

HY-132280R

Tirilazad (Standard) U 74006F free base (Standard)	Antibiotic Reference Standards	Infection Neurological Disease
Estradiol enanthate (Standard) is the analytical standard of Estradiol enanthate. This product is intended for research and analytical applications. Estradiol enanthate is a shorter-acting estrogen. The combination of Estradiol enanthate and dihydroxyprogesterone acetophenide can be used as a monthly injectable contraceptive .

HY-B1836

Meldonium 3 Publications Verification MET-88; Quaterin	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor .

HY-B0683S

Limaprost-d3	Isotope-Labeled Compounds PGE synthase	Cardiovascular Disease Inflammation/Immunology
Limaprost-d₃ (17α,20-dimethyl-δ2-PGE1-d₃) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-121018

Daltroban BM-13505; SKF 96148	Prostaglandin Receptor	Cardiovascular Disease
Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury .

HY-W273690

Pentifylline 1-Hexyltheobromine; Hexyltheobromine	Collagen	Cardiovascular Disease
Pentifylline is a vasodilator with anti-inflammatory activity. Pentifylline inhibits platelet aggregation and thromboxane A2 synthesis, reduces the release of free radicals, and decreases the production of type 1 collagen and laminin in fibroblasts. Pentifylline has the potential to be studied in acute ischemic stroke .

HY-103435

Vialinin A 2 Publications Verification Terrestrin A	Deubiquitinase TNF Receptor E1/E2/E3 Enzyme Keap1-Nrf2	Inflammation/Immunology Cancer
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503

Metoprolol Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503AR

Metoprolol succinate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol (succinate) (Standard) is the analytical standard of Metoprolol (succinate). This product is intended for research and analytical applications. Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503R

Metoprolol (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (Standard) is the analytical standard of Metoprolol. This product is intended for research and analytical applications. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-W008344

2-Chloroadenosine	Nucleoside Antimetabolite/Analog Apoptosis	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
2-Chloroadenosine is an adenosine analog, a transporter permeabilizer of nucleoside transporters, and a competitive uridine influx inhibitor (apparent K_i=33 μM). 2-Chloroadenosine binds to nitrobenzylthioinosine with high affinity (apparent K_i=0.18 mM). 2-Chloroadenosine promotes Apoptosis and increases cerebral blood flow. 2-Chloroadenosine has anticonvulsant properties. 2-Chloroadenosine is used to study infection, inflammatory diseases, cancer, blood-related diseases, lung injury, epilepsy, and kidney disease .

HY-17503BR

Metoprolol tartrate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (tartrate) (Standard) is the analytical standard of Metoprolol (tartrate). This product is intended for research and analytical applications. Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503B

Metoprolol tartrate Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503A

Metoprolol succinate Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-W027553S1

Ipidacrine-d9 NIK-247-d₁₀ free base	Isotope-Labeled Compounds Cholinesterase (ChE) Potassium Channel Sodium Channel	Metabolic Disease
Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17503

Metoprolol 10+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor Apoptosis
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

Cat. No.	Product Name	Chemical Structure

HY-B1448AS

(Rac)-Benidipine-d7
(Rac)-Benidipine-d₇ is the deuterium labeled Benidipine . Benidipine is a potent and orally active calcium channel antagonist . Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells . Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats .

HY-B0162S

Ivabradine-d6
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0683S

Limaprost-d3
Limaprost-d₃ (17α,20-dimethyl-δ2-PGE1-d₃) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-W027553S1

Ipidacrine-d9
Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

Ipidacrine-d9

Ipidacrine-d₉ (NIK-247-d₉ (free base)) is the deuterium labeled Ipidacrine (HY-W027553). Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K+ and Na+-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

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