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Results for "

intraocular

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (24) Apoptosis (5) Bradykinin Receptor (1) Cannabinoid Receptor (5) Carbonic Anhydrase (17) Caspase (2) Chloride Channel (1) CXCR (1) Drug Metabolite (4) Endogenous Metabolite (3) ERK (1) Fluorescent Dye (1) Guanylate Cyclase (2) Interleukin Related (1) Isotope-Labeled Compounds (6) Melatonin Receptor (1) MMP (2) Monoamine Transporter (1) Myosin (1) p38 MAPK (1) Phosphodiesterase (PDE) (2) Potassium Channel (2) Progesterone Receptor (1) Prostaglandin Receptor (28) Reactive Oxygen Species (ROS) (3) Reference Standards (11) ROCK (9) Small Interfering RNA (siRNA) (2) VD/VDR (1) VEGFR (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (28) Endocrinology (17) Infection (2) Inflammation/Immunology (14) Neurological Disease (36)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

107

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142849

Carbonic anhydrase inhibitor 2	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 1 (compound 7c) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-118656

Cannabicitran	Cannabinoid Receptor	Neurological Disease
Cannabicitran is a cannabinoid. Cannabicitran can decrease intraocular pressure in rabbits .

HY-113797

RS-52367	Adrenergic Receptor	Others
RS-52367 is a potent syntex β-adrenergic antagonist. RS-52367 decreases intraocular pressure with a mild systemic effect in dogs .

HY-162226

Carbonic anhydrase inhibitor 19	Carbonic Anhydrase	Others
Carbonic anhydrase inhibitor 19 (compound 26a) inhibits the Glaucoma related isoforms hCA II and hCA XII with K_is of 9.4 nM and 6.7 nM, respectively. Carbonic anhydrase inhibitor 19 reveals an intraocular pressure (IOP) lowering effect .

HY-106206

AL-6598	Prostaglandin Receptor	Cardiovascular Disease
AL-6598 is a partial agonist of the DP and EP prostaglandin receptors. AL-6598 reduces intraocular pressure and is used in glaucoma research .

HY-101303

5-MCA-NAT	Melatonin Receptor	Others
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP .

HY-113756

trans-Latanoprost acid	Prostaglandin Receptor	Others
trans-Latanoprost acid is an isomer of Latanoprost acid. trans-Latanoprost acid may have the activity of reducing intraocular pressure. trans-Latanoprost acid is mainly prepared as an analytical standard for impurity detection and quantification .

HY-142853

Carbonic anhydrase inhibitor 3	Carbonic Anhydrase	Endocrinology
Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits .

HY-B0553R

Methazolamide (Standard) L584601 (Standard)	Reference Standards Carbonic Anhydrase Apoptosis Reactive Oxygen Species (ROS) Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Methazolamide (Standard) is the analytical standard of Methazolamide. This product is intended for research and analytical applications. Methazolamide (L584601) is a BBB-penetrable and orally active carbonic anhydrase inhibitor, with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide can reduce intraocular pressure and has a neuroprotective effect, being able to inhibit neuronal apoptosis. Methazolamide can be used in the research of ophthalmic diseases such as glaucoma and cerebrovascular diseases such as subarachnoid hemorrhage .

HY-124243

N-Cyclopropyl methyl bimatoprost 17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide	Prostaglandin Receptor	Others
N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-139420

Tafluprost ethyl amide	Prostaglandin Receptor	Others
Tafluprost ethyl amide is a prostaglandin derivative. Tafluprost ethyl amide is capable of reducing intraocular pressure (IOP) and influencing eyelash growth. Tafluprost ethyl amide can be used in antiglaucoma ophthalmic compositions .

HY-N3995

5β-Dihydrocortisol	Apoptosis Drug Metabolite	Cancer
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-12720

Apraclonidine ALO 2145 free base	Adrenergic Receptor	Infection Neurological Disease
Apraclonidine (ALO 2145 (free base)), a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution .

HY-12720A

Apraclonidine hydrochloride 2 Publications Verification ALO 2145	Adrenergic Receptor	Neurological Disease
Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid .

HY-124219

17-Phenoxy trinor prostaglandin F2α ethyl amide 17-Phenoxy trinor PGF2α ethyl amide	Prostaglandin Receptor	Others
17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-17642

Omidenepag 1 Publications Verification UR-7276	Prostaglandin Receptor	Endocrinology
Omidenepag (UR-7276), a pharmacologically active form of Omidenepag Isopropyl, is a selective, non-prostanoid EP2 receptor agonist, with an EC₅₀ of 1.1 nM. Omidenepag shows binding affinities (IC₅₀) 10 nM for h-EP2. Omidenepag is used in research on diseases related to intraocular pressure .

HY-B0588A

Brinzolamide hydrochloride AL-4862 hydrochloride	Carbonic Anhydrase	Neurological Disease
Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-106429

OT-551 free base	Reactive Oxygen Species (ROS)	Others
OT-551 (free base) is a lipophilic, disubstituted hydroxylamine with antioxidant properties. OT-551 can be used as an eye drop and can be converted by intraocular esterases to its active metabolite, Tempol-H (TP-H). OT-551 can be utilized in geographic atrophy and macular degeneration research .

HY-B0588

Brinzolamide 4 Publications Verification AL-4862	Carbonic Anhydrase	Cardiovascular Disease Others Neurological Disease
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research .

HY-109545

Isopropyl unoprostone Unoprostone isopropyl ester; UF-021	Potassium Channel	Others
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca ²⁺-activated K ⁺ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity .

HY-139420R

Tafluprost ethyl amide (Standard)	Prostaglandin Receptor Reference Standards	Others
Tafluprost ethyl amide (Standard) is the analytical standard of Tafluprost ethyl amide. This product is intended for research and analytical applications. Tafluprost ethyl amide is a prostaglandin derivative. Tafluprost ethyl amide is capable of intraocular pressure (IOP) reduction and influencing eyelash growth. Tafluprost ethyl amide can be used in antiglaucoma ophthalmic compositions or cosmetics .

HY-111406

Omidenepag isopropyl DE-117	Prostaglandin Receptor	Cardiovascular Disease Inflammation/Immunology
Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isopropyl shows only weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as an intraocular pressure (IOP)-lowering agent.

HY-12720AR

Apraclonidine hydrochloride (Standard) ALO 2145 (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease
Apraclonidine (hydrochloride) (Standard) is the analytical standard of Apraclonidine (hydrochloride). This product is intended for research and analytical applications. Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid .

HY-144705

GAT564	Cannabinoid Receptor	Neurological Disease
GAT564 (Compound 15d) is a potent allosteric modulator of cannabinoid 1 receptor (CB1R) with EC₅₀s of 87 and 320 nM respectively for cAMP and β-arrestin2. GAT564 markedly promotes orthosteric ligand binding to hCB1R. GAT564 is efficacious as a topical agent that significantly reduces intraocular pressure (IOP) in the ocular normotensive murine model of glaucoma .

HY-17380

(S)-Timolol maleate 5 Publications Verification (S)-L-714,465 maleate; MK 950	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Cancer
(S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

HY-106916

Unoprostone	Potassium Channel Chloride Channel	Cardiovascular Disease Neurological Disease
Unoprostone, a prostaglandin F2α analog, is a large conductance Ca ²⁺-activated K ⁺ (BK) channels and ClC-2 type chloride channels activator. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and can be used for the study of glaucoma, ocular hypertension and retinitis pigmentosa .

HY-12798B

Netarsudil hydrochloride AR-13324 hydrochloride	ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting ROCK, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-121902

Butidrine	Adrenergic Receptor	Others
Butidrine is a compound with intraocular pressure-lowering activity that is less effective than some other beta-adrenergic receptor blockers in reducing intraocular pressure in rabbit eyes.

HY-B0553S

Methazolamide-d6 L584601-d₆	Isotope-Labeled Compounds Carbonic Anhydrase	Inflammation/Immunology
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-153483A

Bamosiran sodium SYL040012 sodium	Adrenergic Receptor Small Interfering RNA (siRNA)	Others
Bamosiran sodium is a small interfering RNA targeting β-adrenergic receptor 2, and is used to lower intraocular pressure

HY-153483

Bamosiran SYL040012	Adrenergic Receptor Small Interfering RNA (siRNA)	Others
Bamosiran is a small interfering RNA targeting β-adrenergic receptor 2, and is used to lower intraocular pressure

HY-134224

Arachidonoyl 2'-fluoroethylamide	Cannabinoid Receptor	Endocrinology
Arachidonoyl 2'-fluoroethylamide is an anandamide analog. Arachidonoyl 2'-fluoroethylamide has the potential for the research of intraocular hypertension .

HY-108067

SAD448	Cannabinoid Receptor	Others
SAD448 is a CB1 and CB2 receptor agonist. SAD448 can lower intraocular pressure (IOP) .

HY-106332A

Sezolamide hydrochloride MK 417; (S)-MK-927	Carbonic Anhydrase	Endocrinology
Sezolamide hydrochloride (MK 417) is a potent topical carbonic anhydrase inhibitor. Sezolamide hydrochloride can be used in studies to reduce intraocular pressure .

HY-117090

(rac)-AL-37350A (rac)-4,5-DHP-AMT	5-HT Receptor	Others
(rac)-AL-37350A ((rac)-4,5-DHP-AMT) is a 5-HT2 receptor agonist with intraocular pressure-lowering activity. (rac)-AL-37350A has high affinity and selectivity for the 5-HT2 receptor and effectively reduces intraocular pressure in conscious hypertensive cynomolgus monkeys.

HY-121600

GAT229	Cannabinoid Receptor
GAT229 is a CB1 positive allosteric modulator (PAM) that effectively reduces intraocular pressure (IOP) in high IOP mouse models and enhances CB1 receptor-mediated IOP-lowering effects. A 0.2% GAT229 solution or 10 mg/kg of GAT229 alone significantly reduces IOP. GAT229 is promising for research related to glaucoma and elevated intraocular pressure .

HY-118638

Corynanthine	Adrenergic Receptor	Neurological Disease
Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits .

HY-125946

Latanoprost lactone diol	Prostaglandin Receptor	Inflammation/Immunology
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost. Latanoprost is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP) .

HY-160991

Menabitan SP-204	Phosphodiesterase (PDE)	Others Neurological Disease
Menabitan (SP-204) is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan lowers the intraocular pressure in rabbit model .

HY-B0577S

Latanoprost-d4 PHXA41-d₄	Prostaglandin Receptor	Others
Latanoprost-d₄ is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

HY-121398

Dipivefrin	Adrenergic Receptor Endogenous Metabolite	Others
Dipivefrin is a potent adrenergic agonist. Dipivefrin is an adrenergic pro-agent. Dipivefrin can be used for reduce IOP (intraocular pressure) in patients suffering from chronic open angle glaucoma .

HY-B0397

Dichlorphenamide 1 Publications Verification Diclofenamide	Carbonic Anhydrase	Neurological Disease
Dichlorphenamide (Diclofenamide) is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research .

HY-B0397A

Dichlorphenamide disodium Diclofenamide disodium	Carbonic Anhydrase	Neurological Disease
Dichlorphenamide (Diclofenamide) disodium is an orally active, specific, carbonic anhydrase inhibitor. Dichlorphenamide can reduce intraocular pressure by inhibiting the secretion of water from the eye. Dichlorphenamide can be used for glaucoma research .

HY-19518

Latanoprostene bunod NCX116; LBN	Prostaglandin Receptor	Cardiovascular Disease Neurological Disease Cancer
Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .

HY-12720B

Apraclonidine dihydrochloride ALO 2145 dihydrochloride	Adrenergic Receptor	Neurological Disease
Apraclonidine (ALO 2145) dihydrochloride, a selective α2 and weak α1 receptor agonist activity, effectively low intraocular pressure (IOP) in eyes. Apraclonidine dihydrochloride is a topical ophthalmic solution .

HY-B0577R

Latanoprost (Standard) PHXA41 (Standard)	Reference Standards Prostaglandin Receptor	Others
Latanoprost (Standard) is the analytical standard of Latanoprost. This product is intended for research and analytical applications. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

HY-17494A

Timolol hemihydrate (S)-L-714,465 hemihydrate; MK 950 hemihydrate	Adrenergic Receptor	Infection Cancer
Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect .

HY-160991A

Menabitan dihydrochloride SP-204 dihydrochloride	Phosphodiesterase (PDE)	Others Neurological Disease
Menabitan dihydrochloride (SP-204 dihydrochloride) is the dihydrochloride form of Menabitan (HY-160991). Menabitan dihydrochloride is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan dihydrochloride lowers the intraocular pressure in rabbit model .

HY-B1035A

Levobunolol l-Bunolol	Adrenergic Receptor	Others
Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research .

HY-B1035

Levobunolol hydrochloride 1 Publications Verification l-Bunolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease Others
Levobunolol (l-Bunolol) hydrochloride is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol hydrochloride is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol hydrochloride can be used for glaucoma and superior oblique myokymia (SOM) research .

Cat. No.	Product Name	Type

HY-W110929

Patent Blue V

Acid blue 1

Biochemical Assay Reagents

Patent Blue V (Acid blue 1) is a novel biological dye that can be used as an intraocular dye for retinectomy. Retinectomy refers to the removal of the translucent inner limiting membrane (ILM). The application of appropriate dyes in vitreoretinal surgery can achieve the purpose of complete removal. Patent Blue V can be used to stain retinal premembranous structures. Spectral analysis shows that Patent Blue V has strong absorption below 450 nm and above 600 nm, showing a blue-green color. Patent Blue V is also used as a marker in lymphangiography for resection of neoplastic lymph nodes .

Cat. No.	Product Name	Target	Research Area

HY-P990012

Vamikibart	Interleukin Related	Inflammation/Immunology
Vamikibart (RG6179) is a monoclonal antibody targeting IL-6 that can be used to inhibit uveal macular edema (UME) and reduce retinal leakage. Vamikibart can reduce anterior chamber (AC) cell density, indicating a reduction in intraocular inflammation. Vamikibart can also be used to assess the leakage dynamics of ultra-wide-angle fluorescein angiography (UWFA) in the UME model to quantify changes in retinal leakage reflecting the effect of UME inhibition .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3995

5β-Dihydrocortisol	Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Apoptosis Drug Metabolite
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-118638

Corynanthine	Apocynaceae Structural Classification Alkaloids Source classification Rauvolfia vomitoria Afzel. Plants Indole Alkaloids	Adrenergic Receptor
Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits .

HY-121398

Dipivefrin	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Adrenergic Receptor Endogenous Metabolite
Dipivefrin is a potent adrenergic agonist. Dipivefrin is an adrenergic pro-agent. Dipivefrin can be used for reduce IOP (intraocular pressure) in patients suffering from chronic open angle glaucoma .

HY-N15301

Nocarnickelamide B	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	ROCK Myosin
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC₅₀s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch .

HY-N3995R

5β-Dihydrocortisol (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Reference Standards Apoptosis Drug Metabolite
D-Psicose (Standard) is the analytical standard of D-Psicose. This product is intended for research and analytical applications. D-Psicose is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Chemical Structure

HY-B0577S

Latanoprost-d4
Latanoprost-d₄ is the deuterium labeled Latanoprost. Latanoprost (PHXA41) is a prostaglandin F2α analogue and an agonist for the FP prostanoid receptor, and lowers intraocular-pressure (IOP).

HY-17494S

(Rac)-Timolol-d5 maleate

rac Timolol-d₅ (maleate) is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-B0588AS

Brinzolamide-d5 hydrochloride

Brinzolamide-d₅ (hydrochloride) is the deuterium labeled Brinzolamide hydrochloride . Brinzolamide (AL-4862) hydrochloride is a selective carbonic anhydrase II inhibitor with an IC₅₀ value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide hydrochloride can be used in glaucoma disease research .

HY-N3995S

5β-Dihydrocortisol-d6
5β-Dihydrocortisol-d₆ is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis .

HY-17380S

(S)-Timolol-d9 maleate

(S)-Timolol-d₉ (maleate) is deuterium labeled (S)-Timolol (Maleate). (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction .

HY-17494S1

Timolol-d9 maleate

Timolol-d₉ (maleate) is deuterium labeled Timolol. Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect .

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

Cat. No.	Product Name		Classification

HY-153483A

Bamosiran sodium SYL040012 sodium		siRNAs siRNA drugs
Bamosiran sodium is a small interfering RNA targeting β-adrenergic receptor 2, and is used to lower intraocular pressure

HY-153483

Bamosiran SYL040012		siRNAs siRNA drugs
Bamosiran is a small interfering RNA targeting β-adrenergic receptor 2, and is used to lower intraocular pressure

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