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hydrolysis rate

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21

Inhibitors & Agonists

7

Biochemical Assay Reagents

2

Peptides

1

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P3948
    Fluorescent Substrate for Pro-Specific Proteases

    		Fluorescent Dye Others
    Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .
    Fluorescent Substrate for Pro-Specific Proteases
  • HY-Y0850U4
    PVA (Mw 145000, 99+% hydrolyzed, ～3300 polymerization)

    Polyvinyl alcohol (Mw 145000, 99+% hydrolyzed, ～3300 polymerization); Poly(Ethenol) (Mw 145000, 99+% hydrolyzed, ～3300 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 145000, 99+% hydrolyzed, ～3300 polymerization) is a polyvinyl alcohol with molecular weight of 145000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 145000, 99+% hydrolyzed, ～3300 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 145000, 99+% hydrolyzed, ～3300 polymerization)
  • HY-Y0850U8
    PVA (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization)

    Polyvinyl alcohol (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization); Poly(Ethenol) (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization) is a polyvinyl alcohol with molecular weight of 47000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 47000, 98-99% hydrolyzed, ～1000 polymerization)
  • HY-Y0850U3
    PVA (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization)

    Polyvinyl alcohol (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization); Poly(Ethenol) (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization) is a polyvinyl alcohol with molecular weight of 125000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 125000, 98-99% hydrolyzed, ～2800 polymerization)
  • HY-Y0850U7
    PVA (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization)

    Polyvinyl alcohol (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization); Poly(Ethenol) (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization) is a polyvinyl alcohol with molecular weight of 195000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 195000, 98-99% hydrolyzed, ～4300 polymerization)
  • HY-Y0850U9
    PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization)

    Polyvinyl alcohol (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization); Poly(Ethenol) (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization) is a polyvinyl alcohol with molecular weight of 67000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization)
  • HY-Y0850U5
    PVA (Mw 27000, 98-99% hydrolyzed, ～600 polymerization)

    Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ～600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ～600 polymerization)

    		 Biochemical Assay Reagents Others
    PVA (Mw 27000, 98-99% hydrolyzed, ～600 polymerization) is a polyvinyl alcohol with molecular weight of 27000 with hydrolysis properties. Hydrolysis degree refers to the conversion rate of acetic acid group hydrolysis to hydroxyl group in the original polyvinyl acetate, PVA (Mw 27000, 98-99% hydrolyzed, ～600 polymerization). In addition, polyvinyl alcohol is obtained from polymerization of vinyl acetate to remove acetic acid group by hydrolysis. Polyvinyl alcohol with different degrees of hydrolysis can be self-crosslinked to form frozen gels and used as biological excipients .
    PVA (Mw 27000, 98-99% hydrolyzed, ～600 polymerization)
  • HY-134019
    Arachidonoyl p-nitroaniline

    		Others Others
    Arachidonoyl p-nitroaniline is a substrate for the hydrolysis of p-nitroaniline by FAAH in Dictyostelium discoideum with long-chain unsaturated fatty acids. Arachidonoyl p-nitroaniline can be used in enzyme kinetic studies. Examples include determining the hydrolysis rate of Arachidonoyl p-nitroaniline and analyzing the fatty acid amide hydrolase activity of recombinant His-FAAH purified from Dictyostelium to characterize the binding and catalytic specificity of mammalian FAAH enzymes .
    Arachidonoyl p-nitroaniline
  • HY-111396
    PC58538

    		Bacterial Infection
    PC58538 is a cell division inhibitor, targeting to FtsZ. PC58538 shows moderate antibacterial activity, and inhibits cell division in vegetative cells of wild-type B. subtilis. PC58538 is also known to modulate the rate of GTP hydrolysis .
    PC58538
  • HY-E70095
    T4 UvsY Protein

    		Others Others
    T4 UvsY Protein is an accessory protein for in vitro catalysis of strand exchange. T4 UvsY Protein enhances strand exchange by UvsX protein by interacting specifically with UvsX protein. UvsY protein enhances the rate of single-stranded-DNA-dependent ATP hydrolysis by UvsX protein .
    T4 UvsY Protein
  • HY-P2869A
    β1-3 Galactosidase

    		Glycosidase Metabolic Disease
    β1-3 Galactosidase is a highly specific exoglycosidase that catalyzes the hydrolysis of terminal β1-3-linked galactose from oligosaccharides and glycoprotein substrates, at a much lower rate, β1-6 linked galactose residues from oligosaccharides .
    β1-3 Galactosidase
  • HY-101989
    Tubulin polymerization-IN-24

    		Microtubule/Tubulin Apoptosis Cancer
    Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .
    Tubulin polymerization-IN-24
  • HY-P2818
    Alkaline phosphatase, Bovine intestine
    1 Publications Verification

    Apase

    		 Endogenous Metabolite Glutathione Peroxidase Bacterial Infection Inflammation/Immunology
    Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .
    Alkaline phosphatase, Bovine intestine
  • HY-P2869E
    β1-3,4,6 Galactosidase

    		Endogenous Metabolite Metabolic Disease
    β1-3,4,6 Galactosidase is a broad specificity exoglycosidase that catalyzes the hydrolysis of terminal, non-reducing β1-3 β1-4 and β1-6 linked galactose residues from oligosaccharides, with β1-6 linked galactose residues at a slower rate .
    β1-3,4,6 Galactosidase
  • HY-W250313
    Polylactic acid

    PLA

    		 Biochemical Assay Reagents Others Cancer
    Polylactic acid (PLA) is a biodegradable and biocompatible polymer widely used as a carrier for drug delivery systems and a structural material for tissue engineering and medical implants. Polylactic acid acts as a controlled release matrix through the hydrolysis mechanism of ester bonds, gradually releasing the encapsulated drug and metabolizing to non-toxic lactic acid. Polylactic acid has adjustable degradation rate, mechanical properties and the ability to composite with other polymers, and can be used in local or systemic drug delivery, orthopedic fixation devices and 3D printed bone regeneration scaffolds[1][2].
    Polylactic acid
  • HY-16183A
    Echothiopate chloride

    Echothiophate chloride

    		 Cholinesterase (ChE) Cardiovascular Disease
    Echothiophate (Echothiophate) chloride is a highly effective, long-lasting cholinesterase inhibitor employed as a miotic for managing glaucoma. Echothiopate chloride forms a covalent bond with the serine residue at the active site of cholinesterase through its phosphate group, rendering the enzyme permanently inactive and necessitating the synthesis of new enzymes by the cell. Given its irreversible binding to cholinesterase and the extremely slow rate of hydrolysis, the effects of echothiophate can persist for a week or longer. Echothiopate chloride is utilized as an ocular antihypertensive agent in the treatment of chronic glaucoma and, in certain cases, accommodative esotropia.
    Echothiopate chloride
  • HY-P2893A
    Creatinase (Recombinant)

    Creatine amidinohydrolase

    		 Endogenous Metabolite Metabolic Disease
    Creatinase (Recombinant) is a hydrolase responsible for catalyzing the hydrolysis of creatine (HY-W010388) into sarcosine (HY-101037) and urea (HY-Y0271). Creatinase (Recombinant) can be used in conjunction with creatinine deiminase (HY-P2838) and sarcosine oxidase (HY-P2861) in an enzyme cascade reaction to measure creatinine (HY-B0504) levels in blood and urine. Creatinase (Recombinant) is the rate-limiting enzyme in this enzymatic cascade, and the enzymatic quantification of creatinine is an important method for evaluating kidney function .
    Creatinase (Recombinant)
  • HY-W800839
    TCO-PEG4-TFP ester

    		Biochemical Assay Reagents Others
    TCO-PEG4-TFP Ester is an amine-reactive labeling reagent used to modify proteins, antibodies, and other amine-containing biopolymers. A 2,3,5,6-tetrafluorophenol (TFP) is a reactive ester that displays much better stability toward hydrolysis in aqueous media resulting in more efficiency and better reproducible labeling of biopolymers. TFP ester of carboxylic acids react with primary amines at the same rate as NHS ester forming covalent amide bond that is identical to one formed by the reaction between primary amines and NHS esters or sulfo-NHS esters.
    TCO-PEG4-TFP ester
  • HY-129934
    Latanoprost ethyl amide

    Lat-NEt

    		 Prostaglandin Receptor Endocrinology
    Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
    Latanoprost ethyl amide
  • HY-P5415
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

    		HIV Others
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-kD protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS
  • HY-129934S
    Latanoprost ethyl amide-d4

    Lat-NEt-d4

    		 Isotope-Labeled Compounds Prostaglandin Receptor Endocrinology
    Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .
    Latanoprost ethyl amide-d4

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