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histone deacetylase 6 (HDAC6)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HDAC (14) Histone Demethylase (1) Apoptosis (3) NOD-like Receptor (NLR) (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (4)

14

Inhibitors & Agonists

2

Recombinant Proteins

2

Antibodies

Targets Recommended: Histone Methyltransferase Histone Demethylase Histone Acetyltransferase HDAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HDAC6-IN-46	HDAC	Neurological Disease
HDAC6-IN-46 (compound 12) is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ value of 6.2 nM. HDAC6-IN-46 can be used in Alzheimer's disease research .

SW-100 3 Publications Verification	HDAC	Neurological Disease
SW-100, a selective **histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀** of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays a significantly improved ability to cross the blood-brain-barrier .

HDAC6-IN-38	HDAC	Cancer
HDAC6-IN-38 (Compound Z-7) is an inhibitor for histone deacetylase 6 (HDAC6), with an IC₅₀ of 3.25 nM. HDAC6-IN-38 inhibits proliferation of cells MGC 803 .

HDAC6-IN-41	HDAC	Cancer
HDAC6-IN-41 (Compound E24) is a selective inhibitor for histone deacetylase 6 (HDAC6), with IC₅₀ of 14 and 422 nM, for HDAC6 and HDAC8, respectively. HDAC6-IN-41 upregulates the acetylation of α-tubulin and histone site SMC3 .

HDAC6-IN-15	HDAC	Neurological Disease Cancer
HDAC6-IN-15 is a selective **histone deacetylase 6 (HDAC6)** inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC₅₀ value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases .

LSD1/HDAC6-IN-1	Histone Demethylase HDAC	Cancer
LSD1/HDAC6-IN-1 is an orally active dual inhibitor of lysine specific demethylase 1(LSD1)/Histone deacetylase 6 (HDAC6), with anti-tumor activity. LSD1/HDAC6-IN-1 can be used for the research of multiple myeloma (MM) .

HDAC6-IN-59	HDAC	Cancer
HDAC6-IN-59 (Compound 38k) is a highly selective histone deacetylase 6 (HDAC6) inhibitor (IC₅₀=3.12 nM, with 352-fold selectivity over *HDAC1). HDAC6*-IN-59 is promising for research of esophageal cancer .

(R)-Dihydrolipoic acid	HDAC	Others
(R)-Dihydrolipoic acid is a compound that inhibits histone deacetylase 6 (HDAC6) activity. The structure of its complex with HDAC6 has been resolved. (R)-Dihydrolipoic acid can inhibit HDAC6 through specific interactions, providing a basis for understanding the relationship between HDAC function and oxidative stress.

HDAC6-IN-16	HDAC Apoptosis	Cancer
HDAC6-IN-16 (compound 5c) is a histone deacetylase 6 (HDAC6) inhibitor, based on Quinazolin-4(3H)-One. HDAC6-IN-16 exhibits anticancer effect, inhibits colony-forming. And HDAC6-IN-16 arrests cell cycle at G2 phase and induces apoptosis .

HDAC6-IN-54	HDAC NOD-like Receptor (NLR)	Inflammation/Immunology
HDAC6-IN-54 (Compound 9m) is a highly selective *HDAC6* (histone deacetylase 6) inhibitor with an IC₅₀ value of 0.021 μM. HDAC6-IN-54 blocks the activation of the NLRP3 inflammasome, which alleviates symptoms of NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis .

ACY-775 2 Publications Verification	HDAC	Cardiovascular Disease Neurological Disease
ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC₅₀ of 7.5 nM . ACY775 also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) .

PTG-0861	HDAC Apoptosis	Cancer
PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC₅₀ value of 5.92 nM. PTG-0861 induces apoptosis and can be used in the study of acute myeloid leukemia, multiple myeloma and other hematological cancers .

HDAC6-IN-53	HDAC	Inflammation/Immunology
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by bleomycin (HY-108345). HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases.

SelSA	HDAC Apoptosis	Cancer
SelSA is a selective, orally active inhibitor for **histone deacetylase 6** (HDAC6) with IC₅₀ of 56.9 nM. SelSA inhibits the phosphorylation of ERK1/2. SelSA inhibits the proliferation of breast cancer cells and hepatocellular carcinoma cells with IC₅₀ of 0.58-2.6 μM, inhibits cell migration and invasion of Huh7, and induces apoptosis. SelSA exhibits antitumor activity in mouse model .

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	HDAC6 Protein, Human (His) CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	E. coli
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (His) is the recombinant human-derived HDAC6 protein, expressed by E. coli , with N-6*His labeled tag.

	HDAC6 Protein, Human (sf9, His) CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	Sf9 insect cells
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (sf9, His) is the recombinant human-derived HDAC6 protein, expressed by Sf9 insect cells, with C-8*His labeled tag.

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	HDAC6 Antibody (YA740) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB	Human, Rat
	HDAC6 Antibody (YA740) is a non-conjugated and Mouse origined monoclonal antibody about 131 kDa, targeting to HDAC6 (3B2). It can be used for WB assays with tag free, in the background of Human, Rat.

	HDAC6 Antibody (YA5795) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HDAC6 Antibody (YA5795) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC6. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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