gut dysbiosis

By Targets:	Akt (1) Calcium Channel (2) Drug Metabolite (2) Endogenous Metabolite (1) Fungal (3) PI3K (1) Protein Arginine Deiminase (1) Reference Standards (2) TNF Receptor (1) Toll-like Receptor (TLR) (1) Tyrosinase (1)
By Research Areas:	Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1134

Imazalil 1 Publications Verification Enilconazole	Fungal	Infection
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-B1134A

Imazalil sulfate 1 Publications Verification Enilconazolel sulfate	Fungal	Infection
Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-N12670

Egg oil	PI3K Akt Toll-like Receptor (TLR)	Neurological Disease Metabolic Disease Inflammation/Immunology
Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation .

HY-128696

Amlodipine aspartic acid impurity Amlodipine aspartate	Drug Metabolite Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

HY-W013636C

2-Ketoglutaric acid potassium 5 Publications Verification Alpha-Ketoglutaric acid potassium	Tyrosinase Endogenous Metabolite TNF Receptor	Neurological Disease Metabolic Disease
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

HY-123606

GSK484	Protein Arginine Deiminase	Inflammation/Immunology
GSK484 is a PAD4 inhibitor. GSK484 reduces inflammation and joint destruction in CIA mouse models. GSK484 inhibits TNF-α expression and reverses Erastin-induced gut dysbiosis. GSK484 can be used in rheumatoid arthritis (RA) research .

HY-B1134R

Imazalil (Standard) Enilconazole (Standard)	Reference Standards Fungal	Infection
Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-128696R

Amlodipine aspartic acid impurity (Standard) Amlodipine aspartate (Standard)	Drug Metabolite Reference Standards Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

Cat. No.	Product Name

HY-L078

Gut Microbial Metabolite Library	496 compounds
Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods. In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 496 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Gut Microbial Metabolite Library

496 compounds

Accumulating evidence has revealed that intestinal microbiota play an important role in human health and disease, including cardiovascular diseases, inflammatory bowel disease, diabetes, obesity, cancer, and depression, etc. Changes in the composition of gut microbiota associated with disease, referred to as dysbiosis, have been linked to pathologies. Indeed, the gut microbiome functions like an endocrine organ, generating bioactive metabolites which play important roles in human metabolism, health, and disease. Gut microbiome has become a novel therapeutic target for many diseases. Analysis and identification of gut microbial metabolite will contribute to the development of therapeutic methods.

In order to meet the need of gut microbiome research, MCE carefully selected a unique collection of 496 gut microbial metabolites. MCE gut microbial metabolite library is a powerful tool for gut microbiome research and gut microbiome -related drug discovery.

Cat. No.	Product Name	Type

HY-W013636C

2-Ketoglutaric acid potassium 5 Publications Verification Alpha-Ketoglutaric acid potassium	Biochemical Assay Reagents
2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

2-Ketoglutaric acid potassium

5 Publications Verification

Alpha-Ketoglutaric acid potassium

Biochemical Assay Reagents

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

Cat. No.	Product Name	Target	Research Area

HY-128696

Amlodipine aspartic acid impurity Amlodipine aspartate	Drug Metabolite Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

HY-128696R

Amlodipine aspartic acid impurity (Standard) Amlodipine aspartate (Standard)	Drug Metabolite Reference Standards Calcium Channel	Cardiovascular Disease
Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1134

Imazalil 1 Publications Verification Enilconazole	Infection Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Biological Pesticide Research Agricultural Research	Fungal
Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

HY-N12670

Egg oil	Structural Classification Natural Products Animals Source classification	PI3K Akt Toll-like Receptor (TLR)
Egg oil is a natural oil, which consists primarily of cholesterol, lecithin and glycerides of the fatty acids. Egg oil exhibits activity in regulating the gut microbial dysbiosis, alleviating obesity, insulin resistance and inflammation .

HY-B1134R

Imazalil (Standard) Enilconazole (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards Fungal
Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder .

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gut dysbiosis

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

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